BioDrugs
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The Future of Antisense Oligonucleotides in the Treatment of Respiratory Diseases
BioDrugs - Tập 20 - Trang 1-11 - 2012
Antisense oligonucleotides (ASO) are short synthetic DNA molecules designed to inhibit translation of a targeted gene to protein via interaction with messenger RNA. More recently, small interfering (si)RNA have been developed as potent tools to specifically inhibit gene expression. ASO directed against signaling molecules, cytokine receptors, and transcription factors involved in allergic immune a......
Tumour Necrosis Factor in Sarcoidosis and its Potential for Targeted Therapy
BioDrugs - Tập 17 - Trang 425-431 - 2012
Tumour necrosis factor (TNF)-α is a potent cytokine involved in the inflammatory reactions of many acute and chronic diseases. Recently, agents that block TNFα either directly or indirectly have been successful in the treatment of a variety of immune-mediated inflammatory disorders including rheumatoid arthritis and Crohn’s disease. Sarcoidosis is an immune-mediated inflammatory disorder character......
Biosimilar Drugs
BioDrugs - Tập 21 - Trang 351-356 - 2012
Patents for biologic agents first marketed in the 1980s are now beginning to expire, opening the door for ‘nonproprietary’ versions of these agents to enter the market. However, there are fundamental differences between biologics and traditional pharmaceuticals that preclude the extrapolation of existing regulatory processes for traditional generic agents to these new biologic products. These incl......
Pharmacotherapy of Perennial and Seasonal Allergic Rhinitis
BioDrugs - Tập 3 - Trang 308-324 - 2012
The options for pharmacotherapy of both perennial and seasonal allergic rhinitis continue to expand rapidly. The classic antihistamines will retain a place as effective drugs. They are without serious adverse effects, and are often available without a physician’s prescription. The newer antihistamines, such as terfenadine, astemizole, loratadine and cetirizine, have made a great impact because the......
Tolerability and Reactogenicity Profile of mRNA SARS-Cov-2 Vaccines from a Mass Vaccination Campaign in a Tertiary Hospital: Between-Vaccine and Between-Population Prospective Observational Study (VigilVacCOVID Study)
BioDrugs - Tập 36 - Trang 509-520 - 2022
The comparative safety profile of SARS-Cov2 vaccines requires further characterization in real-world settings. The aim of the VigilVacCOVID study was to assess the short-term safety of BNT162b2 and mRNA-1273 during the vaccination campaign of healthcare professionals (HCPs) and solid-organ transplant recipients (SOTRs) at a hospital clinic. We conducted an observational, prospective, single-center......
Blood Products for Hemophilia
BioDrugs - Tập 18 - Trang 225-234 - 2012
Hemophilia is an inherited bleeding disorder, which in its severe form is characterized by recurrent hemarthrosis and internal bleeding. In the absence of effective treatment the prognosis is poor, but the development of blood products in the last few decades has transformed the outlook, and patients can now live essentially normal lives. Treatment options vary around the world, with cryoprecipita......
The Use of Radiolabelled Monoclonal Antibodies in the Diagnosis of Colorectal Carcinomas
BioDrugs - Tập 6 - Trang 200-210 - 2012
The development of monoclonal antibodies (mAbs) using the hybridoma technology has led to new approaches for imaging cancer patients. mAbs against carcinoembryonic antigen (CEA) or TAG-72, two tumour-associated antigens expressed by the vast majority of colorectal adenocarcinomas, have been successfully conjugated with various radionuclides such as I-131, I-123, Tc-99m and In-111. Clinical trials ......
Genetic Polymorphisms Influencing Therapy and Susceptibility to Rejection in Organ Allograft Recipients
BioDrugs - Tập 16 - Trang 11-17 - 2012
Solid organ transplantation during the past 30 years has developed from an experimental procedure into routine clinical practice. The current repertoire of immunosuppressive agents has made a major contribution to transplant survival; however, problems in different areas still need to be overcome. Several gene polymorphisms are supposed to influence immunosuppressive therapy and susceptibility to ......
Cyclin-Dependent Kinase Modulators and Cancer Therapy
BioDrugs - Tập 26 - Trang 377-391 - 2012
The cell cycle of eukaryotic cells varies greatly from species to species and tissue to tissue. Since an erroneous control of the cell cycle can have disastrous consequences for cellular life, there are genetically programmed signals, so-called cell cycle checkpoints, which ensure that all events of each stage are completed before beginning the next phase. Among the numerous molecules involved in ......
Systemic and Mucosal Delivery of Drugs within Polymeric Microparticles Produced by Spray Drying
BioDrugs - Tập 24 - Trang 359-377 - 2012
Encapsulation of therapeutic and diagnostic materials into polymeric particles is a means to protect and control or target the release of active substances such as drugs, vaccines, and genetic material. In terms of mucosal delivery, polymeric encapsulation can be used to promote absorption of the active substance, while particles can improve the half-life of drugs administered systemically. Spray ......
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