BioDrugs
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Reply to Scalone and Cortesi: “Cost-Utility Analysis of Biologic Therapies to Treat Chronic Plaque Psoriasis in Italy: The Importance of Using Updated and Adequate Social Tariffs to Calculate QALYs”
BioDrugs - Tập 29 - Trang 71-72 - 2015
The Future of Antisense Oligonucleotides in the Treatment of Respiratory Diseases
BioDrugs - Tập 20 - Trang 1-11 - 2012
Antisense oligonucleotides (ASO) are short synthetic DNA molecules designed to inhibit translation of a targeted gene to protein via interaction with messenger RNA. More recently, small interfering (si)RNA have been developed as potent tools to specifically inhibit gene expression. ASO directed against signaling molecules, cytokine receptors, and transcription factors involved in allergic immune a......
Liệu pháp dựa trên tế bào với tế bào điều hòa T Dịch bởi AI
BioDrugs - Tập 31 - Trang 335-347 - 2017
Tế bào điều hòa T (Tregs) CD4+CD25highFoxP3+ là những tác nhân ức chế nổi bật trong hệ miễn dịch. Tregs sử dụng nhiều cơ chế khác nhau để kiểm soát các phản ứng miễn dịch. Dữ liệu tiền lâm sàng từ các mô hình động vật đã xác nhận tiềm năng điều trị to lớn của Tregs trong nhiều bệnh lý liên quan đến miễn dịch. Do đó, những tế bào này đang trên con đường chuyển giao thành liệu pháp tế bào trong lâm ......
#Tế bào điều hòa T #liệu pháp tế bào #hệ miễn dịch #bệnh lý miễn dịch
In-Use Stability of the Rituximab Biosimilar CT-P10 (Truxima®) Following Preparation for Intravenous Infusion and Storage
BioDrugs - Tập 33 - Trang 221-228 - 2019
CT-P10 is the first biosimilar of the anti-CD20 monoclonal antibody, rituximab. CT-P10 is currently available in over 51 countries worldwide, where it is approved in the same indications as its reference product rituximab. In-use stability studies are conducted for biologics to determine how conditions (e.g., temperature, light, humidity, length of time stored) affect drug quality following diluti......
Localised Delivery of Macromolecules to the Large Intestine: Translation to Clinical Trials
BioDrugs - Tập 36 - Trang 687-700 - 2022
Oral administration of macromolecules aimed at systemic delivery has been at the forefront of pharmaceutical research for over 50 years. Yet, in terms of clinical translation for systemic delivery, output is limited to five US Food and Drug Administration (FDA)-approved oral peptide products to date, such are the hurdles. Somewhat neglected by comparison but with potentially lower delivery demands......
Tumour Necrosis Factor in Sarcoidosis and its Potential for Targeted Therapy
BioDrugs - Tập 17 - Trang 425-431 - 2012
Tumour necrosis factor (TNF)-α is a potent cytokine involved in the inflammatory reactions of many acute and chronic diseases. Recently, agents that block TNFα either directly or indirectly have been successful in the treatment of a variety of immune-mediated inflammatory disorders including rheumatoid arthritis and Crohn’s disease. Sarcoidosis is an immune-mediated inflammatory disorder character......
Biosimilar Drugs
BioDrugs - Tập 21 - Trang 351-356 - 2012
Patents for biologic agents first marketed in the 1980s are now beginning to expire, opening the door for ‘nonproprietary’ versions of these agents to enter the market. However, there are fundamental differences between biologics and traditional pharmaceuticals that preclude the extrapolation of existing regulatory processes for traditional generic agents to these new biologic products. These incl......
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