Daily treatment with sildenafil, an inhibitor of cGMP-dependent phosphodiesterase, normalizes the exaggerated hemodynamic response to norepinephrine in fructose-fed ratsBMC Pharmacology - - 2007
Delphine Behr‐Roussel, Alexandra Oudot, Sandrine Compagnie, Diana Gorny, Olivier Le Coz, Jaques Bernabé, Chris Wayman, L Alexandre, François Giuliano
A covalent peptide inhibitor of RGS4 identified in a focused one-bead, one compound library screenBMC Pharmacology - Tập 9 - Trang 1-11 - 2009
Rebecca A Roof, David L Roman, Samuel T Clements, Katarzyna Sobczyk-Kojiro, Levi L Blazer, Shodai Ota, Henry I Mosberg, Richard R Neubig
Regulators of G protein signaling (RGSs) accelerate GTP hydrolysis by Gα subunits and profoundly inhibit signaling by G protein-coupled receptors (GPCRs). The distinct expression patterns and pathophysiologic regulation of RGS proteins suggest that inhibitors may have therapeutic potential. We recently described a focused one-bead, one-compound (OBOC) library screen to identify peptide inhibitors ...... hiện toàn bộ