BMC Pharmacology

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Structural and functional definition of the specificity of a novel caspase-3 inhibitor, Ac-DNLD-CHO
BMC Pharmacology - Tập 7 - Trang 1-16 - 2007
Atsushi Yoshimori, Junichi Sakai, Satoshi Sunaga, Takanobu Kobayashi, Satoshi Takahashi, Naoyuki Okita, Ryoko Takasawa, Sei-ichi Tanuma
The rational design of peptide-based specific inhibitors of the caspase family members using their X-ray crystallographies is an important strategy for chemical knockdown to define the critical role of each enzyme in apoptosis and inflammation. Recently, we designed a novel potent peptide inhibitor, Ac-DNLD-CHO, for caspase-3 using a new computational screening system named the Amino acid Position...... hiện toàn bộ
Daily treatment with sildenafil, an inhibitor of cGMP-dependent phosphodiesterase, normalizes the exaggerated hemodynamic response to norepinephrine in fructose-fed rats
BMC Pharmacology - - 2007
Delphine Behr‐Roussel, Alexandra Oudot, Sandrine Compagnie, Diana Gorny, Olivier Le Coz, Jaques Bernabé, Chris Wayman, L Alexandre, François Giuliano
Effect of a short-term in vitro exposure to the marine toxin domoic acid on viability, tumor necrosis factor-alpha, matrix metalloproteinase-9 and superoxide anion release by rat neonatal microglia
BMC Pharmacology - Tập 1 - Trang 1-13 - 2001
Alejandro MS Mayer, Mary Hall, Michael J Fay, Peter Lamar, Celeste Pearson, Walter C Prozialeck, Virginia KB Lehmann, Peer B Jacobson, Anne M Romanic, Tolga Uz, Hari Manev
The excitatory amino acid domoic acid, a glutamate and kainic acid analog, is the causative agent of amnesic shellfish poisoning in humans. No studies to our knowledge have investigated the potential contribution to short-term neurotoxicity of the brain microglia, a cell type that constitutes circa 10% of the total glial population in the brain. We tested the hypothesis that a short-term in vitro ...... hiện toàn bộ
Riociguat dose titration in patients with chronic thromboembolic pulmonary hypertension (CTEPH) or pulmonary arterial hypertension (PAH)
BMC Pharmacology - Tập 9 - Trang 1-1 - 2009
Hossein A Ghofrani, Marius M Hoeper, Gert Hoeffken, Michael Halank, Gerrit Weimann, Friedrich Grimminger
Antidepressant drugs modulate growth factors in cultured cells
BMC Pharmacology - Tập 8 - Trang 1-8 - 2008
Andreas W Henkel, Wolfgang Sperling, Andrea Rotter, Udo Reulbach, Cornelia Reichardt, Dominikus Bönsch, Juan M Maler, Johannes Kornhuber, Jens Wiltfang
Different classes of antidepressant drugs are used as a treatment for depression by activating the catecholinergic system. In addition, depression has been associated with decrease of growth factors, which causes insufficient axonal sprouting and reduced neuronal damage repair. In this study, antidepressant treatments are analyzed in a cell culture system, to study the modulation of growth factors...... hiện toàn bộ
Sertraline and amitriptyline enhance histamine metabolism in guinea-pig tissues
BMC Pharmacology - Tập 9 - Trang 1-1 - 2009
Simona Rajtar, Tatjana Irman-Florjanc
Mutations in the amino-terminus impair amphetamine-induced efflux by inducing inward-facing conformations of the serotonin transporter
BMC Pharmacology - Tập 9 Số S2 - 2009
Sonja Sučić, Stephan Dallinger, Barbara Zdrazil, Oliver Kudlacek, Walter Sandtner, Gerhard Ecker, Michael Freissmuth, Harald H. Sitte
Pharmacological characterization of receptor guanylyl cyclase reporter cell lines
BMC Pharmacology - Tập 9 - Trang 1-1 - 2009
Frank Wunder, Daniel Barufe, Annette Woermann, Markus Milde
C-type natriuretic peptide is a bifurcation factor for sensory neurons
BMC Pharmacology - Tập 9 - Trang 1-2 - 2009
Hannes Schmidt, Agne Stonkute, René Jüttner, Doris Koesling, Andreas Friebe, Robert Feil, Franz Hofmann, Fritz G Rathjen
Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells
BMC Pharmacology - Tập 8 - Trang 1-15 - 2008
Jillian G Baker
The H3 histamine receptor is a Gi-coupled GPCR that has been proven to exist in different agonist-induced states, including that defined by the protean agonist proxyfan. Several GPCRs are now known to exist in different states. For some of these, antagonist affinity measurement remain constant regardless of the state of the receptor, for others e.g. the beta-adrenoceptors, the antagonist affinity ...... hiện toàn bộ
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