BMC Medicine
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Diagnostic delay for giant cell arteritis – a systematic review and meta-analysis
BMC Medicine - Tập 15 - Trang 1-12 - 2017
Giant cell arteritis (GCA), if untreated, can lead to blindness and stroke. The study’s objectives were to (1) determine a new evidence-based benchmark of the extent of diagnostic delay for GCA and (2) examine the role of GCA-specific characteristics on diagnostic delay. Medical literature databases were searched from inception to November 2015. Articles were included if reporting a time-period of......
Prospective association of the Mediterranean diet with cardiovascular disease incidence and mortality and its population impact in a non-Mediterranean population: the EPIC-Norfolk study
BMC Medicine - Tập 14 - Trang 1-11 - 2016
Despite convincing evidence in the Mediterranean region, the cardiovascular benefit of the Mediterranean diet is not well established in non-Mediterranean countries and the optimal criteria for defining adherence are unclear. The population attributable fraction (PAF) of adherence to this diet is also unknown. In the UK-based EPIC-Norfolk prospective cohort, we evaluated habitual diets assessed at......
Measuring the completeness of death registration in 2844 Chinese counties in 2018
BMC Medicine - Tập 18 - Trang 1-11 - 2020
Death registration completeness has never been assessed at the county level in China. Such analyses would provide critical intelligence to monitor the performance of the vital registration system and yield adjustment factors to correct death registration data, thereby increasing their policy utility. We estimated the completeness of death registration for 31 provinces and 2844 counties of China in......
Factors associated with requesting and receiving euthanasia: a nationwide mortality follow-back study with a focus on patients with psychiatric disorders, dementia, or an accumulation of health problems related to old age
BMC Medicine - Tập 17 - Trang 1-12 - 2019
Recently, euthanasia and assisted suicide (EAS) in patients with psychiatric disorders, dementia, or an accumulation of health problems has taken a prominent place in the public debate. However, limited is known about this practice. The purpose of this study was threefold: to estimate the frequency of requesting and receiving EAS among people with (also) a psychiatric disorder, dementia, or an acc......
Next generation sequencing and tumor mutation profiling: are we ready for routine use in the oncology clinic?
BMC Medicine - Tập 12 - Trang 1-8 - 2014
Next generation sequencing (NGS) coupled with sophisticated bioinformatics tools yields an unprecedented amount of information regarding tumor genetics, with the potential to reveal insights into tumor behavior. NGS and other multiplex genomic assays are rapidly spilling from the laboratory into the clinic through numerous commercial and academic entities. This raises the important question as to ......
Meta-analysis of the prognostic and clinical value of tumor-associated macrophages in adult classical Hodgkin lymphoma
BMC Medicine - Tập 14 - Trang 1-11 - 2016
The prognostic significance of tumor-associated macrophages (TAM) in adult classical Hodgkin lymphoma (cHL) remains controversial. Here, we report a meta-analysis of the association of CD68 and CD163 infiltration on the clinical outcome of adult cHL. A comprehensive search to identify relevant articles was performed in PubMed, Embase, and Google Scholar on January 31, 2016. Using the fixed effect ......
Quantifying circulating hypoxia-induced RNA transcripts in maternal blood to determine in uterofetal hypoxic status
BMC Medicine - Tập 11 - Trang 1-12 - 2013
Hypoxia in utero can lead to stillbirth and severe perinatal injury. While current prenatal tests can identify fetuses that are hypoxic, none can determine the severity of hypoxia/acidemia. We hypothesized a hypoxic/acidemic fetus would up-regulate and release hypoxia-induced mRNA from the fetoplacental unit into the maternal circulation, where they can be sampled and quantified. Furthermore, we h......
Longitudinal evolution of sleep disturbances in early multiple system atrophy: a 2‐year prospective cohort study
BMC Medicine - Tập 21 - Trang 1-12 - 2023
The progression of sleep disturbances remains unclear in patients with early multiple system atrophy (MSA). We aimed to explore the frequency, severity, and coexistence of 2-year longitudinal changes of sleep disturbances including REM sleep behavior disorder (RBD), excessive daytime sleepiness (EDS), and Parkinson’s disease-related sleep problems (PD-SP) in early MSA. MSA patients with a disease ......
Why we need a small data paradigm
BMC Medicine - Tập 17 - Trang 1-9 - 2019
There is great interest in and excitement about the concept of personalized or precision medicine and, in particular, advancing this vision via various ‘big data’ efforts. While these methods are necessary, they are insufficient to achieve the full personalized medicine promise. A rigorous, complementary ‘small data’ paradigm that can function both autonomously from and in collaboration with big d......
Tổng số: 2,886
- 1
- 2
- 3
- 4
- 5
- 6
- 10