BMC Medicine

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Reliability analysis of exonic-breakpoint fusions identified by DNA sequencing for predicting the efficacy of targeted therapy in non-small cell lung cancer
BMC Medicine - Tập 20 - Trang 1-13 - 2022
Weihua Li, Rui Wan, Lei Guo, Geyun Chang, Dong Jiang, Lin Meng, Jianming Ying
Diverse genomic breakpoints of fusions that localize to intronic, exonic, or intergenic regions have been identified by DNA next-generation sequencing (NGS), but the role of exonic breakpoints remains elusive. We investigated whether exonic-breakpoint fusions could predict matched targeted therapy efficacy in non-small cell lung cancer (NSCLC). NSCLC samples were analyzed by DNA NGS, RNA NGS, immu...... hiện toàn bộ
Reducing ignorance about who dies of what: research and innovation to strengthen CRVS systems
BMC Medicine - - 2020
Alan D. Lopez, Deirdre McLaughlin, Nicola Richards
The Sustainable Development Goal (SDG) agenda offers a major impetus to consolidate and accelerate development in civil registration and vital statistics (CRVS) systems. Strengthening CRVS systems is an SDG outcome in itself. Moreover, CRVS systems are the best – if not essential – source of data to monitor and guide health policy debates and to assess progress towards numerous SDG targets and ind...... hiện toàn bộ
Notch signaling in pediatric soft tissue sarcomas
BMC Medicine - Tập 10 - Trang 1-13 - 2012
Rossella Rota, Roberta Ciarapica, Lucio Miele, Franco Locatelli
Pediatric soft tissue sarcomas are rare tumors of childhood, frequently characterized by specific chromosome translocations. Despite improvements in treatment, their clinical management is often challenging due to the low responsiveness of metastatic forms and aggressive variants to conventional therapeutic approaches, which leads to poor overall survival. It is widely thought that soft tissue sar...... hiện toàn bộ
Surveys of current status in biomedical science grant review: funding organisations' and grant reviewers' perspectives
BMC Medicine - - 2010
Sara Schroter, Trish Groves, Liselotte Højgaard
Apps for asthma self-management: a systematic assessment of content and tools
BMC Medicine - Tập 10 - Trang 1-11 - 2012
Kit Huckvale, Mate Car, Cecily Morrison, Josip Car
Apps have been enthusiastically adopted by the general public. They are increasingly recognized by policy-makers as a potential medium for supporting self-management of long-term conditions. We assessed the degree to which current smartphone and tablet apps for people with asthma offer content and tools of appropriate quality to support asthma self-management. We adapted systematic review methodol...... hiện toàn bộ
The three-legged stool of evidence-based practice in eating disorder treatment: research, clinical, and patient perspectives
BMC Medicine - Tập 14 - Trang 1-8 - 2016
Carol B. Peterson, Carolyn Black Becker, Janet Treasure, Roz Shafran, Rachel Bryant-Waugh
Evidence-based practice in eating disorders incorporates three essential components: research evidence, clinical expertise, and patient values, preferences, and characteristics. Conceptualized as a ‘three-legged stool’ by Sackett et al. in 1996 (BMJ), all of these components of evidence-based practice are considered essential for providing optimal care in the treatment of eating disorders. However...... hiện toàn bộ
A new noninvasive technique for estimating hepatic triglyceride: will liver biopsy become redundant in diagnosing non-alcoholic fatty liver disease?
BMC Medicine - - 2014
Bark Betzel, Joost P.H. Drenth
Functional somatic disorders: discussion paper for a new common classification for research and clinical use
BMC Medicine - Tập 18 Số 1 - 2020
Christopher Burton, Per Fink, Peter Henningsen, Bernd Löwe, Winfried Rief
Abstract Background Functional somatic symptoms and disorders are common and complex phenomena involving both bodily and brain processes. They pose major challenges across medical specialties. These disorders are common and have significant impacts on patients’ quality of life and healthcare costs. <...... hiện toàn bộ
Identifying and prioritizing lower value services from Dutch specialist guidelines and a comparison with the UK do-not-do list
BMC Medicine - Tập 14 - Trang 1-9 - 2016
Joost Johan Godert Wammes, M. Elske van den Akker-van Marle, Eva W. Verkerk, Simone A. van Dulmen, Gert P. Westert, Antoinette D. I. van Asselt, R. B. Kool
The term ‘lower value services’ concerns healthcare that is of little or no value to the patient and consequently should not be provided routinely, or not be provided at all. De-adoption of lower value care may occur through explicit recommendations in clinical guidelines. The present study aimed to generate a comprehensive list of lower value services for the Netherlands that assesses the type of...... hiện toàn bộ
Migration and tuberculosis transmission in a middle-income country: a cross-sectional study in a central area of São Paulo, Brazil
BMC Medicine - Tập 16 - Trang 1-10 - 2018
Julia Moreira Pescarini, Vera Simonsen, Lucilaine Ferrazoli, Laura C. Rodrigues, Rosangela S. Oliveira, Eliseu Alves Waldman, Rein Houben
Little is known about the impact of growing migration on the pattern of tuberculosis (TB) transmission in middle-income countries. We estimated TB recent transmission and its associated factors and investigated the presence of cross-transmission between South American migrants and Brazilians. We studied a convenient sample of cases of people with pulmonary TB in a central area of São Paulo, Brazil...... hiện toàn bộ
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