BMC Medicine

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Novel therapeutic agents in clinical development for systemic lupus erythematosus
BMC Medicine - Tập 11 - Trang 1-11 - 2013
Natasha Jordan, Pamela MK Lutalo, David P D’Cruz
Conventional immunosuppressive therapies have radically transformed patient survivalin systemic lupus erythematosus (SLE), but their use is associated with considerabletoxicity and a substantial proportion of patients remain refractory to treatment. Amore comprehensive understanding of the complexity of SLE immunopathogenesis hasevolved over the past decade and has led to the testing of several bi...... hiện toàn bộ
Incorporating social vulnerability in infectious disease mathematical modelling: a scoping review
BMC Medicine - - 2024
Megan Naidoo, Whitney Shephard, Innocensia Kambewe, Nokuthula Mtshali, Sky Cope, Felipe Alves Rubio, Davide Rasella
Highlighted by the rise of COVID-19, climate change, and conflict, socially vulnerable populations are least resilient to disaster. In infectious disease management, mathematical models are a commonly used tool. Researchers should include social vulnerability in models to strengthen their utility in reflecting real-world dynamics. We conducted a scoping review to evaluate how researchers have inco...... hiện toàn bộ
Which placebo to cure depression? A thought-provoking network meta-analysis
BMC Medicine - Tập 11 Số 1 - 2013
Florian Naudet, Bruno Millet, Philippe Charlier, Jean-Michel Reymann, Anne Solène Maria, Bruno Falissard
Sleep alterations as a function of 88 health indicators
BMC Medicine -
Péter Przemyslaw Ujma, Róbert Bódizs
Abstract Background Alterations in sleep have been described in multiple health conditions and as a function of several medication effects. However, evidence generally stems from small univariate studies. Here, we apply a large-sample, data-driven approach to investigate patterns between in sleep ma...... hiện toàn bộ
An exploratory study examining how nano-liquid chromatography–mass spectrometry and phosphoproteomics can differentiate patients with advanced fibrosis and higher percentage collagen in non-alcoholic fatty liver disease
BMC Medicine - Tập 16 - Trang 1-13 - 2018
Zobair M. Younossi, Azza Karrar, Mariaelena Pierobon, Aybike Birerdinc, Maria Stepanova, Dinan Abdelatif, Zahra Younoszai, Thomas Jeffers, Sean Felix, Kianoush Jeiran, Alex Hodge, Weidong Zhou, Fanny Monge, Lakshmi Alaparthi, Vikas Chandhoke, Zachary D. Goodman, Emanuel F. Petricoin
Non-alcoholic steatohepatitis (NASH) is among the leading causes of liver disease worldwide. It is increasingly recognized that the phenotype of NASH may involve a number of different pathways, of which each could become important therapeutic targets. The aim of this study is to use high resolution mass spectrometry (MS) and phosphoproteomics techniques to assess the serum proteome and hepatic pho...... hiện toàn bộ
Dementia subtype and living well: results from the Improving the experience of Dementia and Enhancing Active Life (IDEAL) study
BMC Medicine - Tập 16 - Trang 1-9 - 2018
Yu-Tzu Wu, Linda Clare, John V. Hindle, Sharon M. Nelis, Anthony Martyr, Fiona E. Matthews
The heterogeneity of symptoms across dementia subtypes has important implications for clinical practice and dementia research. Variation in subtypes and associated symptoms may influence the capability to live well for people with dementia and carers. The aim of this study is to investigate the potential impact of dementia subtypes on the capability to live well for both people with dementia and t...... hiện toàn bộ
A better understanding of the association between maternal perception of foetal movements and late stillbirth—findings from an individual participant data meta-analysis
BMC Medicine - Tập 19 - Trang 1-12 - 2021
John M. D. Thompson, Jessica Wilson, Billie F. Bradford, Minglan Li, Robin S. Cronin, Adrienne Gordon, Camille H. Raynes-Greenow, Tomasina Stacey, Vicki M. Cullling, Lisa M. Askie, Louise M. O’Brien, Edwin A. Mitchell, Lesley M. E. McCowan, Alexander E. P. Heazell
Late stillbirth continues to affect 3–4/1000 pregnancies in high-resource settings, with even higher rates in low-resource settings. Reduced foetal movements are frequently reported by women prior to foetal death, but there remains a poor understanding of the reasons and how to deal with this symptom clinically, particularly during the preterm phase of gestation. We aimed to determine which women ...... hiện toàn bộ
Male- and female-specific reproductive risk factors across the lifespan for dementia or cognitive decline: a systematic review and meta-analysis
BMC Medicine - Tập 21 - Trang 1-12 - 2023
Shuang-Ling Han, De-Chun Liu, Chen-Chen Tan, Lan Tan, Wei Xu
Sex difference exists in the prevalence of dementia and cognitive decline. The impacts of sex-specific reproductive risk factors across the lifespan on the risk of dementia or cognitive decline are still unclear. Herein, we conducted this systemic review and meta-analysis to finely depict the longitudinal associations between sex-specific reproductive factors and dementia or cognitive decline. Pub...... hiện toàn bộ
What does matrix metalloproteinase-1 expression in patients with breast cancer really tell us?
BMC Medicine - Tập 9 - Trang 1-7 - 2011
Ferdinando Mannello
Molecular and biochemical expressions of matrix metalloproteinases in breast cancer tissue and cells offers promise in helping us understand the breast cancer microenvironment, and also in the future it is hoped this will improve its detection, treatment and prognosis. In a retrospective study recently published in BMC Cancer, microenvironment predisposing to breast cancer progression, metastatic ...... hiện toàn bộ
Glucagon-like peptide-1 receptor agonists and diabetic retinopathy: nationwide cohort and Mendelian randomization studies
BMC Medicine - Tập 21 - Trang 1-10 - 2023
Deqiang Zheng, Ning Li, Rui Hou, Xiaoyu Zhang, Lijuan Wu, Jan Sundquist, Kristina Sundquist, Jianguang Ji
The ability of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) to decrease certain microvascular events has called for the investigation of GLP-1 RAs against diabetic retinopathy (DR), but the evidence is limited. By combining data from observational and Mendelian randomization (MR) studies, we aimed to investigate whether GLP-1 RAs decrease the risk of DR. We combined data from several Swed...... hiện toàn bộ
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