BMC Genetics

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Comparison of weighting approaches for genetic risk scores in gene-environment interaction studies
BMC Genetics - Tập 18 - Trang 1-12 - 2017
Anke Hüls, Ursula Krämer, Christopher Carlsten, Tamara Schikowski, Katja Ickstadt, Holger Schwender
Weighted genetic risk scores (GRS), defined as weighted sums of risk alleles of single nucleotide polymorphisms (SNPs), are statistically powerful for detection gene-environment (GxE) interactions. To assign weights, the gold standard is to use external weights from an independent study. However, appropriate external weights are not always available. In such situations and in the presence of predo...... hiện toàn bộ
Power and sample size calculations in the presence of phenotype errors for case/control genetic association studies
BMC Genetics - Tập 6 - Trang 1-12 - 2005
Brian J Edwards, Chad Haynes, Mark A Levenstien, Stephen J Finch, Derek Gordon
Phenotype error causes reduction in power to detect genetic association. We present a quantification of phenotype error, also known as diagnostic error, on power and sample size calculations for case-control genetic association studies between a marker locus and a disease phenotype. We consider the classic Pearson chi-square test for independence as our test of genetic association. To determine as...... hiện toàn bộ
Improving the efficiency of feed utilization in poultry by selection. 1. Genetic parameters of anatomy of the gastro-intestinal tract and digestive efficiency
BMC Genetics - Tập 12 - Trang 1-9 - 2011
Hugues de Verdal, Agnès Narcy, Denis Bastianelli, Hervé Chapuis, Nathalie Même, Séverine Urvoix, Elisabeth Le Bihan-Duval, Sandrine Mignon-Grasteau
Feed costs represent about 70% of the costs of raising broilers. The main way to decrease these costs is to improve feed efficiency by modification of diet formulation, but one other possibility would be to use genetic selection. Understanding the genetic architecture of the gastro-intestinal tract (GIT) and the impact of the selection criterion on the GIT would be of particular interest. We there...... hiện toàn bộ
Recombination of the porcine X chromosome: a high density linkage map
BMC Genetics - Tập 15 - Trang 1-6 - 2014
Ana I Fernández, María Muñoz, Estefânia Alves, Josep María Folch, Jose Luis Noguera, Miguel Pérez Enciso, Maria del Carmen Rodríguez, Luis Silió
Linkage maps are essential tools for the study of several topics in genome biology. High density linkage maps for the porcine autosomes have been constructed exploiting the high density data provided by the PorcineSNP60 BeadChip. However, a high density SSCX linkage map has not been reported up to date. The aim of the current study was to build an accurate linkage map of SSCX to provide precise es...... hiện toàn bộ
Genetic diversity among eight Dendrolimus species in Eurasia (Lepidoptera: Lasiocampidae) inferred from mitochondrial COI and COII, and nuclear ITS2 markers
BMC Genetics - Tập 17 Số S3 - 2016
Alexander Kononov, Kirill Ustyantsev, Baode Wang, Victor C. Mastro, Victor Fet, А. Г. Блинов, Yuri N. Baranchikov
Genome-wide deficiency screen for the genomic regions responsible for heat resistance in Drosophila melanogaster
BMC Genetics - - 2011
Kazuo H. Takahashi, Yasukazu Okada, Kouhei Teramura
Genotyping human ancient mtDNA control and coding region polymorphisms with a multiplexed Single-Base-Extension assay: the singular maternal history of the Tyrolean Iceman
BMC Genetics - Tập 10 - Trang 1-14 - 2009
Phillip Endicott, Juan J Sanchez, Irene Pichler, Paul Brotherton, Jerome Brooks, Eduard Egarter-Vigl, Alan Cooper, Peter Pramstaller
Progress in the field of human ancient DNA studies has been severely restricted due to the myriad sources of potential contamination, and because of the pronounced difficulty in identifying authentic results. Improving the robustness of human aDNA results is a necessary pre-requisite to vigorously testing hypotheses about human evolution in Europe, including possible admixture with Neanderthals. T...... hiện toàn bộ
Comparison of missing data approaches in linkage analysis
BMC Genetics - Tập 4 - Trang 1-4 - 2003
Chao Xing, Fredrick R Schumacher, David V Conti, John S Witte
Observational cohort studies have been little used in linkage analyses due to their general lack of large, disease-specific pedigrees. Nevertheless, the longitudinal nature of such studies makes them potentially valuable for assessing the linkage between genotypes and temporal trends in phenotypes. The repeated phenotype measures in cohort studies (i.e., across time), however, can have extensive m...... hiện toàn bộ
Candidate genes in quantitative trait loci associated with absolute and relative kidney weight in rats with Inherited Stress Induced Arterial Hypertension
BMC Genetics - Tập 16 - Trang 1-13 - 2015
Olga E Redina, Svetlana E Smolenskaya, Leonid O Klimov, Arcady L Markel
The kidney mass is significantly increased in hypertensive ISIAH rats with Inherited Stress Induced Arterial Hypertension as compared with normotensive WAG rats. The QTL/microarray approach was carried out to determine the positional candidate genes in the QTL for absolute and relative kidney weight. Several known and predicted genes differentially expressed in ISIAH and WAG kidney were mapped to ...... hiện toàn bộ
Estimation of genetic parameters and detection of quantitative trait loci for minerals in Danish Holstein and Danish Jersey milk
BMC Genetics - Tập 16 - Trang 1-8 - 2015
Bart Buitenhuis, Nina A Poulsen, Lotte B Larsen, Jakob Sehested
Bovine milk provides important minerals, essential for human nutrition and dairy product quality. For changing the mineral composition of the milk to improve dietary needs in human nutrition and technological properties of milk, a thorough understanding of the genetics underlying milk mineral contents is important. Therefore the aim of this study was to 1) estimate the genetic parameters for indiv...... hiện toàn bộ
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