BMC Cell Biology

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Glucose-induced gradual phenotypic modulation of cultured human glomerular epithelial cells may be independent of Wilms’ tumor 1 (WT1)
BMC Cell Biology - Tập 14 - Trang 1-12 - 2013
Nikolaos E Tsotakos, Marina Sagnou, Eleni S Kotsopoulou, Effie C Tsilibary, Garyfalia I Drossopoulou
Renal podocytes form the main filtration barrier possessing a unique phenotype maintained by proteins including podocalyxin and nephrin, the expression of which is suppressed in pathological conditions. We used an in vitro model of human glomerular epithelial cells (HGEC) to investigate the role of high glucose in dysregulating the podocytic epithelial phenotype and determined the time needed for ...... hiện toàn bộ
Musashi1 expression cells derived from mouse embryonic stem cells can be enriched in side population isolated by fluorescence activated cell sorter
BMC Cell Biology - - 2011
Tao Yu, Lei Zhao, Shaoyang Lan, Miao-Jing Fan, Yu Gong, Liu Shi, Yuhong Yuan, Kaihong Huang, Qi‐Kui Chen
Abstract Background Purifying stem cells is an inevitable process for further investigation and cell-therapy. Sorting side population (SP) cells is generally regarded as an effective method to enrich for progenitor cells. This study was to explore whether sorting SP could enrich for the Musashi1 ...... hiện toàn bộ
Lysosomal trafficking functions of mucolipin-1 in murine macrophages
BMC Cell Biology - Tập 8 - Trang 1-16 - 2007
Eric G Thompson, Lara Schaheen, Hope Dang, Hanna Fares
Mucolipidosis Type IV is currently characterized as a lysosomal storage disorder with defects that include corneal clouding, achlorhydria and psychomotor retardation. MCOLN1, the gene responsible for this disease, encodes the protein mucolipin-1 that belongs to the "Transient Receptor Potential" family of proteins and has been shown to function as a non-selective cation channel whose activity is m...... hiện toàn bộ
Separation of functionally divergent muscle precursor cell populations from porcine juvenile muscles by discontinuous Percoll density gradient centrifugation
BMC Cell Biology - Tập 19 Số 1 - Trang 1-12 - 2018
Miersch, Claudia, Stange, Katja, Röntgen, Monika
Satellite cells (SC) and their descendants, muscle precursor cells (MPC), play a key role in postnatal muscle development, regeneration, and plasticity. Several studies have provided evidence that SC and MPC represent a heterogeneous population differing in their biochemical and functional properties. The identification and characterization of functionally divergent SC subpopulations should help t...... hiện toàn bộ
cAMP-dependent and cholinergic regulation of the electrogenic intestinal/pancreatic Na+/HCO3- cotransporter pNBC1 in human embryonic kidney (HEK293) cells
BMC Cell Biology - Tập 9 - Trang 1-11 - 2008
Oliver Bachmann, Kristin Franke, Haoyang Yu, Brigitte Riederer, Hong C Li, Manoocher Soleimani, Michael P Manns, Ursula Seidler
The renal (kNBC1) and intestinal (pNBC1) electrogenic Na+/HCO3- cotransporter variants differ in their primary structure, transport direction, and response to secretagogues. Previous studies have suggested that regulatory differences between the two subtypes can be partially explained by unique consensus phosphorylation sites included in the pNBC1, but not the kNBC1 sequence. After having shown ac...... hiện toàn bộ
αS1-casein, which is essential for efficient ER-to-Golgi casein transport, is also present in a tightly membrane-associated form
BMC Cell Biology - Tập 11 - Trang 1-15 - 2010
Annabelle Le Parc, Joëlle Leonil, Eric Chanat
Caseins, the main milk proteins, aggregate in the secretory pathway of mammary epithelial cells into large supramolecular structures, casein micelles. The role of individual caseins in this process and the mesostructure of the casein micelle are poorly known. In this study, we investigate primary steps of casein micelle formation in rough endoplasmic reticulum-derived vesicles prepared from rat or...... hiện toàn bộ
Roles of CUP-5, the Caenorhabditis elegans orthologue of human TRPML1, in lysosome and gut granule biogenesis
BMC Cell Biology - Tập 11 - Trang 1-10 - 2010
Erin M Campbell, Hanna Fares
CUP-5 is a Transient Receptor Potential protein in C. elegans that is the orthologue of mammalian TRPML1. Loss of TRPML1 results in the lysosomal storage disorder Mucolipidosis type IV. Loss of CUP-5 results in embryonic lethality and the accumulation of enlarged yolk granules in developing intestinal cells. The embryonic lethality of cup-5 mutants is rescued by mutations in mrp-4, which is requir...... hiện toàn bộ
Uptake of long chain fatty acids is regulated by dynamic interaction of FAT/CD36 with cholesterol/sphingolipid enriched microdomains (lipid rafts)
BMC Cell Biology - Tập 9 Số 1 - 2008
Robert Ehehalt, Richard Sparla, Hasan Kulaksiz, Thomas Herrmann, Joachim Füllekrug, Wolfgang Stremmel
Physalis angulata induces in vitro differentiation of murine bone marrow cells into macrophages
BMC Cell Biology - Tập 15 - Trang 1-11 - 2014
Bruno José Martins da Silva, Ana Paula D Rodrigues, Luis Henrique S Farias, Amanda Anastácia P Hage, Jose Luiz M Do Nascimento, Edilene O Silva
The bone marrow is a hematopoietic tissue that, in the presence of cytokines and growth factors, generates all of the circulating blood cells. These cells are important for protecting the organism against pathogens and for establishing an effective immune response. Previous studies have shown immunomodulatory effects of different products isolated from plant extracts. This study aimed to evaluate ...... hiện toàn bộ
Phospholipase Cδ điều chỉnh sự nảy mầm của bào tử Dictyostelium Dịch bởi AI
BMC Cell Biology - Tập 2 - Trang 1-7 - 2001
Peter Van Dijken, Peter JM Van Haastert
Nhiều sinh vật nhân chuẩn, bao gồm thực vật và nấm, tạo ra bào tử có khả năng chống chịu với các điều kiện môi trường khắc nghiệt. Sinh vật vi mô Dictyostelium chứa một gen phospholipase C (PLC); việc loại bỏ gen này không ảnh hưởng đến sự phát triển, chuyển động tế bào và biệt hóa. Trong báo cáo này, chúng tôi cho thấy rằng PLC là yếu tố thiết yếu để cảm nhận môi trường của bào tử được kích hoạt ...... hiện toàn bộ
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