Glucose-induced gradual phenotypic modulation of cultured human glomerular epithelial cells may be independent of Wilms’ tumor 1 (WT1)BMC Cell Biology - Tập 14 - Trang 1-12 - 2013
Nikolaos E Tsotakos, Marina Sagnou, Eleni S Kotsopoulou, Effie C Tsilibary, Garyfalia I Drossopoulou
Renal podocytes form the main filtration barrier possessing a unique phenotype maintained by proteins including podocalyxin and nephrin, the expression of which is suppressed in pathological conditions. We used an in vitro model of human glomerular epithelial cells (HGEC) to investigate the role of high glucose in dysregulating the podocytic epithelial phenotype and determined the time needed for ...... hiện toàn bộ
Lysosomal trafficking functions of mucolipin-1 in murine macrophagesBMC Cell Biology - Tập 8 - Trang 1-16 - 2007
Eric G Thompson, Lara Schaheen, Hope Dang, Hanna Fares
Mucolipidosis Type IV is currently characterized as a lysosomal storage disorder with defects that include corneal clouding, achlorhydria and psychomotor retardation. MCOLN1, the gene responsible for this disease, encodes the protein mucolipin-1 that belongs to the "Transient Receptor Potential" family of proteins and has been shown to function as a non-selective cation channel whose activity is m...... hiện toàn bộ
Different effects of rat interferon alpha, beta and gamma on rat hepatic stellate cell proliferation and activationBMC Cell Biology - Tập 3 - Trang 1-8 - 2002
Hong Shen, Manna Zhang, Gerald Y Minuk, Yuewen Gong
Liver fibrosis is the common sequel of chronic liver diseases. Recent studies have identified hepatic stellate cells as the primary cell type mediating hepatic fibrogenesis. It has been demonstrated that hepatic stellate cells undergo a process of activation during the development of liver fibrosis. During the activation process, hepatic stellate cells acquire myofibroblast-like phenotype featurin...... hiện toàn bộ
The histone methyltransferase SUV420H2 and Heterochromatin Proteins HP1 interact but show different dynamic behavioursBMC Cell Biology - Tập 10 - Trang 1-16 - 2009
Patricia P Souza, Pamela Völkel, Dave Trinel, Julien Vandamme, Claire Rosnoblet, Laurent Héliot, Pierre-Olivier Angrand
Histone lysine methylation plays a fundamental role in chromatin organization and marks distinct chromatin regions. In particular, trimethylation at lysine 9 of histone H3 (H3K9) and at lysine 20 of histone H4 (H4K20) governed by the histone methyltransferases SUV39H1/2 and SUV420H1/2 respectively, have emerged as a hallmark of pericentric heterochromatin. Controlled chromatin organization is cruc...... hiện toàn bộ
MAB21L2, a vertebrate member of the Male-abnormal 21 family, modulates BMP signaling and interacts with SMAD1BMC Cell Biology - - 2004
Danila Baldessari, Aurora Badaloni, Renato Longhi, Vincenzo Zappavigna, G Giacomo Consalez
Through in vivo loss-of-function studies, vertebrate members of the Male abnormal 21 (mab-21) gene family have been implicated in gastrulation, neural tube formation and eye morphogenesis. Despite mounting evidence of their considerable importance in development, the biochemical properties and nature of MAB-21 proteins have remained strikingly elusive. In addition, genetic studies conducted in C. ...... hiện toàn bộ
cAMP-dependent and cholinergic regulation of the electrogenic intestinal/pancreatic Na+/HCO3- cotransporter pNBC1 in human embryonic kidney (HEK293) cellsBMC Cell Biology - Tập 9 - Trang 1-11 - 2008
Oliver Bachmann, Kristin Franke, Haoyang Yu, Brigitte Riederer, Hong C Li, Manoocher Soleimani, Michael P Manns, Ursula Seidler
The renal (kNBC1) and intestinal (pNBC1) electrogenic Na+/HCO3- cotransporter variants differ in their primary structure, transport direction, and response to secretagogues. Previous studies have suggested that regulatory differences between the two subtypes can be partially explained by unique consensus phosphorylation sites included in the pNBC1, but not the kNBC1 sequence. After having shown ac...... hiện toàn bộ