BMC Biology
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Ubiquitylation is required for the incorporation of the Notch receptor into intraluminal vesicles to prevent prolonged and ligand-independent activation of the pathway
BMC Biology - Tập 20 - Trang 1-25 - 2022
Ubiquitylation of the ligands and the receptor plays an important part in the regulation of the activity of the evolutionary conserved Notch signalling pathway. However, its function for activation of Notch is not completely understood, despite the identification of several E3 ligases devoted to the receptor. Here we analysed a variant of the Notch receptor where all lysines in its intracellular d......
A nontuberculous mycobacterium could solve the mystery of the lady from the Franciscan church in Basel, SwitzerlandAbstract
Background
In 1975, the mummified body of a female has been found in the Franciscan church in Basel, Switzerland. Molecular and genealogic analyses unveiled her identity as Anna Catharina Bischoff (ACB), a member of the upper class of post-reformed Basel, who died at the age of 68 years, in... ...
BMC Biology -
Genome of the parasitoid wasp Cotesia chilonis sheds light on amino acid resource exploitation
BMC Biology - Tập 20 - Trang 1-17 - 2022
A fundamental feature of parasitism is the nutritional exploitation of host organisms by their parasites. Parasitoid wasps lay eggs on arthropod hosts, exploiting them for nutrition to support larval development by using diverse effectors aimed at regulating host metabolism. However, the genetic components and molecular mechanisms at the basis of such exploitation, especially the utilization of ho......
Retargeting azithromycin analogues to have dual-modality antimalarial activity
BMC Biology - Tập 18 - Trang 1-23 - 2020
Resistance to front-line antimalarials (artemisinin combination therapies) is spreading, and development of new drug treatment strategies to rapidly kill Plasmodium spp. malaria parasites is urgently needed. Azithromycin is a clinically used macrolide antibiotic proposed as a partner drug for combination therapy in malaria, which has also been tested as monotherapy. However, its slow-killing ‘dela......
Diet of Mesozoic toothed birds (Longipterygidae) inferred from quantitative analysis of extant avian diet proxies
BMC Biology - Tập 20 - Trang 1-37 - 2022
Birds are key indicator species in extant ecosystems, and thus we would expect extinct birds to provide insights into the nature of ancient ecosystems. However, many aspects of extinct bird ecology, particularly their diet, remain obscure. One group of particular interest is the bizarre toothed and long-snouted longipterygid birds. Longipterygidae is the most well-understood family of enantiornith......
Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm
BMC Biology - Tập 4 - Trang 1-13 - 2006
The provision of stress resistance diverts resources from development and reproduction and must therefore be tightly regulated. In Caenorhabditis elegans, the switch to increased stress resistance to promote survival through periods of starvation is regulated by the DAF-16/FOXO transcription factor. Reduction-of-function mutations in AGE-1, the C. elegans Class IA phosphoinositide 3-kinase (PI3K),......
The human Na+/H+ exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2
BMC Biology - Tập 14 Số 1 - Trang 1-17 - 2016
Extracellular signal-regulated kinase 2 (ERK2) is an S/T kinase with more than 200 known substrates, and with critical roles in regulation of cell growth and differentiation and currently no membrane proteins have been linked to ERK2 scaffolding. Here, we identify the human Na+/H+ exchanger 1 (hNHE1) as a membrane scaffold protein for ERK2 and show direct hNHE1-ERK1/2 interaction in cellular conte......
Open Questions: We don’t really know anything, do we? Open questions in sensory biology
BMC Biology - Tập 15 - Trang 1-3 - 2017
Senses connect organisms to both the world and to each other, yet there is much we don’t know about them. Using examples drawn primarily from the author’s subfield of vision research, this article discusses five major open questions.
Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal diseaseAbstract
Background
Scales are mineralised exoskeletal structures that are part of the dermal skeleton. Scales have been mostly lost during evolution of terrestrial vertebrates whilst bony fish have retained a mineralised dermal skeleton in the form of fin rays and scales. Each scale is a mineralise... ...
BMC Biology - Tập 20 Số 1 - 2022
Cue-driven microbial cooperation and communication: evolving quorum sensing with honest signaling
BMC Biology - - 2024
Quorum sensing (QS) is the ability of microorganisms to assess local clonal density by measuring the extracellular concentration of signal molecules that they produce and excrete. QS is also the only known way of bacterial communication that supports the coordination of within-clone cooperative actions requiring a certain threshold density of cooperating cells. Cooperation aided by QS communicatio......
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