BMC Biology

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Single swim sessions in C. elegans induce key features of mammalian exercise
BMC Biology - Tập 15 - Trang 1-17 - 2017
Ricardo Laranjeiro, Girish Harinath, Daniel Burke, Bart P. Braeckman, Monica Driscoll
Exercise exerts remarkably powerful effects on metabolism and health, with anti-disease and anti-aging outcomes. Pharmacological manipulation of exercise benefit circuits might improve the health of the sedentary and the aging populations. Still, how exercised muscle signals to induce system-wide health improvement remains poorly understood. With a long-term interest in interventions that promote ...... hiện toàn bộ
Proteasome inhibition, the pursuit of new cancer therapeutics, and the adaptor molecule p130Cas
BMC Biology - Tập 9 Số 1 - 2011
Dharminder Chauhan, Kenneth C. Anderson
Ubiquitylation is required for the incorporation of the Notch receptor into intraluminal vesicles to prevent prolonged and ligand-independent activation of the pathway
BMC Biology - Tập 20 - Trang 1-25 - 2022
Björn Schnute, Hideyuki Shimizu, Marvin Lyga, Martin Baron, Thomas Klein
Ubiquitylation of the ligands and the receptor plays an important part in the regulation of the activity of the evolutionary conserved Notch signalling pathway. However, its function for activation of Notch is not completely understood, despite the identification of several E3 ligases devoted to the receptor. Here we analysed a variant of the Notch receptor where all lysines in its intracellular d...... hiện toàn bộ
Time-resolved dual transcriptomics reveal early induced Nicotiana benthamiana root genes and conserved infection-promoting Phytophthora palmivora effectors
BMC Biology - - 2017
Édouard Evangelisti, Anna Gogleva, Thomas Hainaux, Mehdi Doumane, Frej Tulin, ClĂŠment Quan, T. S. Yunusov, Kévin Floch, Sebastián Schornack
Rapid identification of mosquito species and age by mass spectrometric analysis
BMC Biology - Tập 21 - Trang 1-20 - 2023
Iris Wagner, Linda Grigoraki, Peter Enevoldson, Michael Clarkson, Sam Jones, Jane L. Hurst, Robert J. Beynon, Hilary Ranson
A rapid, accurate method to identify and to age-grade mosquito populations would be a major advance in predicting the risk of pathogen transmission and evaluating the public health impact of vector control interventions. Whilst other spectrometric or transcriptomic methods show promise, current approaches rely on challenging morphological techniques or simple binary classifications that cannot ide...... hiện toàn bộ
A nontuberculous mycobacterium could solve the mystery of the lady from the Franciscan church in Basel, Switzerland
BMC Biology -
Mohamed S. Sarhan, Christina Wurst, Alexandar Tzankov, Andreas J. Bircher, Holger Wittig, Thomas Briellmann, Marc Augsburger, Günter Hotz, Albert Zink, Frank Maixner
Abstract Background In 1975, the mummified body of a female has been found in the Franciscan church in Basel, Switzerland. Molecular and genealogic analyses unveiled her identity as Anna Catharina Bischoff (ACB), a member of the upper class of post-reformed Basel, who died at the age of 68 years, in...... hiện toàn bộ
ADARs regulate cuticle collagen expression and promote survival to pathogen infection
BMC Biology -
Alfa Dhakal, Chinnu Salim, Mary Skelly, Yarden Amichan, Ayelet T. Lamm, Heather A. Hundley
Abstract Background In all organisms, the innate immune system defends against pathogens through basal expression of molecules that provide critical barriers to invasion and inducible expression of effectors that combat infection. The adenosine deaminase that act on RNA (ADAR) family of RNA-binding ...... hiện toàn bộ
Lethal (2) giant discs (Lgd)/CC2D1 is required for the full activity of the ESCRT machinery
BMC Biology - Tập 18 - Trang 1-21 - 2020
Miriam Baeumers, Kristina Ruhnau, Thomas Breuer, Hendrik Pannen, Bastian Goerlich, Anna Kniebel, Sebastian Haensch, Stefanie Weidtkamp-Peters, Lutz Schmitt, Thomas Klein
A major task of the endosomal sorting complex required for transport (ESCRT) machinery is the pinching off of cargo-loaded intraluminal vesicles (ILVs) into the lumen of maturing endosomes (MEs), which is essential for the complete degradation of transmembrane proteins in the lysosome. The ESCRT machinery is also required for the termination of signalling through activated signalling receptors, as...... hiện toàn bộ
Hibernation-like state induced by an opioid peptide protects against experimental stroke
BMC Biology - Tập 7 - Trang 1-10 - 2009
Cesar V Borlongan, Teruo Hayashi, Peter R Oeltgen, Tsung-Ping Su, Yun Wang
Delta opioid peptide [D-ala2,D-leU5]enkephalin (DADLE) induces hibernation in summer ground squirrels, and enhances preservation and survival of isolated or transplanted lungs and hearts. In the present study, we investigated the protective effect of DADLE in the central nervous system. Adult Sprague-Dawley rats were pretreated with DADLE (4 mg/kg every 2 h × 4 injections, i.p.) or saline prior to...... hiện toàn bộ
Genome of the parasitoid wasp Cotesia chilonis sheds light on amino acid resource exploitation
BMC Biology - Tập 20 - Trang 1-17 - 2022
Xinhai Ye, Shijiao Xiong, Ziwen Teng, Yi Yang, Jiale Wang, Kaili Yu, Huizi Wu, Yang Mei, Cheng Xue, Zhichao Yan, Chuanlin Yin, Fang Wang, Hongwei Yao, Qi Fang, Qisheng Song, Gongyin Ye, Fei Li
A fundamental feature of parasitism is the nutritional exploitation of host organisms by their parasites. Parasitoid wasps lay eggs on arthropod hosts, exploiting them for nutrition to support larval development by using diverse effectors aimed at regulating host metabolism. However, the genetic components and molecular mechanisms at the basis of such exploitation, especially the utilization of ho...... hiện toàn bộ
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