BMC Biology

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Nâng cấp siêu cấu trúc và gắn chromosome để cải thiện các bộ gen Anopheles Dịch bởi AI
BMC Biology - Tập 18 Số 1 - 2020
Robert M. Waterhouse, Sergey Aganezov, Yoann Anselmetti, Jiyoung Lee, Livio Ruzzante, Maarten Reijnders, Romain Féron, Sèverine Bérard, Phillip George, Matthew W. Hahn, Paul Howell, Maryam Kamali, Sergey Koren, Daniel Lawson, Gareth Maslen, Ashley Peery, Adam M. Phillippy, Maria V. Sharakhova, Éric Tannier, Maria Unger, Simo V. Zhang, Max A. Alekseyev, Nora J. Besansky, Cédric Chauve, Scott M. Emrich, Igor V. Sharakhov
Tóm tắt Nền tảng Các công nghệ giải trình tự mới đã giảm bớt rào cản tài chính đối với việc giải trình tự toàn bộ gen, nhưng các bộ gen thu được thường bị phân mảnh và còn xa khỏi trạng thái ‘hoàn chỉnh’. Việc cập nhật các bản dự thảo đa cấu trúc lên trạng thái cấp nhiễm sắc thể có thể đạt được thôn...... hiện toàn bộ
#các công nghệ giải trình tự #cấu trúc đa #công nghệ RNAseq #Anopheles #bảo tồn thứ tự gen
Open questions: why should we care about ER-phagy and ER remodelling?
BMC Biology - Tập 16 - Trang 1-5 - 2018
Ivan Dikic
The endoplasmic reticulum (ER) is one of the most complex organelles in the eukaryotic cell. Recent findings suggest that a process called ER-phagy plays a major role in maintaining the ER’s shape and function.
Massively parallel tag sequencing reveals the complexity of anaerobic marine protistan communities
BMC Biology - Tập 7 - Trang 1-20 - 2009
Thorsten Stoeck, Anke Behnke, Richard Christen, Linda Amaral-Zettler, Maria J Rodriguez-Mora, Andrei Chistoserdov, William Orsi, Virginia P Edgcomb
Recent advances in sequencing strategies make possible unprecedented depth and scale of sampling for molecular detection of microbial diversity. Two major paradigm-shifting discoveries include the detection of bacterial diversity that is one to two orders of magnitude greater than previous estimates, and the discovery of an exciting 'rare biosphere' of molecular signatures ('species') of poorly un...... hiện toàn bộ
Q&A: How does peptide signaling direct plant development?
BMC Biology - Tập 14 - Trang 1-7 - 2016
Maike Breiden, Rüdiger Simon
A significant part of the communication between plant cells is mediated by signaling peptides and their corresponding plasma membrane-localized receptor-like kinases. This communication mechanism serves as a key regulatory unit for coordination of plant growth and development. In the past years more peptide–receptor signaling pathways have been shown to regulate developmental processes, such as sh...... hiện toàn bộ
The evolving world of pseudoenzymes: proteins, prejudice and zombies
BMC Biology - - 2016
Patrick A. Eyers, James M. Murphy
Modality matters for the expression of inducible defenses: introducing a concept of predator modality
BMC Biology - Tập 11 Số 1 - 2013
Quirin Herzog, Christian Laforsch
The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells
BMC Biology - Tập 14 - Trang 1-22 - 2016
Elizabeth A. Stanford, Zhongyan Wang, Olga Novikov, Francesca Mulas, Esther Landesman-Bollag, Stefano Monti, Brenden W. Smith, David C. Seldin, George J. Murphy, David H. Sherr
Self-renewing, chemoresistant breast cancer stem cells are believed to contribute significantly to cancer invasion, migration and patient relapse. Therefore, the identification of signaling pathways that regulate the acquisition of stem-like qualities is an important step towards understanding why patients relapse and towards development of novel therapeutics that specifically target cancer stem c...... hiện toàn bộ
Author Correction to: Single-cell RNA-seq reveals a concomitant delay in differentiation and cell cycle of aged hematopoietic stem cells
BMC Biology - Tập 19 - Trang 1-2 - 2021
Léonard Hérault, Mathilde Poplineau, Adrien Mazuel, Nadine Platet, Élisabeth Remy, Estelle Duprez
An amendment to this paper has been published and can be accessed via the original article.
Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor
BMC Biology - Tập 2 - Trang 1-12 - 2004
Jeffrey N Joyce, Cheryl Woolsey, Han Ryoo, Sabine Borwege, Diane Hagner
Our aim was to determine if pramipexole, a D3 preferring agonist, effectively reduced dopamine neuron and fiber loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model when given at intraperitoneal doses corresponding to clinical doses. We also determined whether subchronic treatment with pramipexole regulates dopamine transporter function, thereby reducing intracellular transp...... hiện toàn bộ
Generation and physiological roles of linear ubiquitin chains
BMC Biology - Tập 10 - Trang 1-6 - 2012
Henning Walczak, Kazuhiro Iwai, Ivan Dikic
Ubiquitination now ranks with phosphorylation as one of the best-studied post-translational modifications of proteins with broad regulatory roles across all of biology. Ubiquitination usually involves the addition of ubiquitin chains to target protein molecules, and these may be of eight different types, seven of which involve the linkage of one of the seven internal lysine (K) residues in one ubi...... hiện toàn bộ
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