BMC Biology

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The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells
BMC Biology - Tập 14 - Trang 1-22 - 2016
Elizabeth A. Stanford, Zhongyan Wang, Olga Novikov, Francesca Mulas, Esther Landesman-Bollag, Stefano Monti, Brenden W. Smith, David C. Seldin, George J. Murphy, David H. Sherr
Self-renewing, chemoresistant breast cancer stem cells are believed to contribute significantly to cancer invasion, migration and patient relapse. Therefore, the identification of signaling pathways that regulate the acquisition of stem-like qualities is an important step towards understanding why patients relapse and towards development of novel therapeutics that specifically target cancer stem c...... hiện toàn bộ
Control of vein network topology by auxin transport
BMC Biology - Tập 13 - Trang 1-16 - 2015
Carla Verna, Megan G. Sawchuk, Nguyen Manh Linh, Enrico Scarpella
Tissue networks such as the vascular networks of plant and animal organs transport signals and nutrients in most multicellular organisms. The transport function of tissue networks depends on topological features such as the number of networks’ components and the components’ connectedness; yet what controls tissue network topology is largely unknown, partly because of the difficulties in quantifyin...... hiện toàn bộ
Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline
BMC Biology - Tập 19 Số 1 - 2021
Qipeng Cheng, Yan Chu Cheung, Chenyu Liu, Qi Xiao, Binyong Sun, Jiahai Zhou, Edward Wai Chi Chan, Rong Zhang, Sheng Chen
Abstract Background Tigecycline is a tetracycline derivative that constitutes one of the last-resort antibiotics used clinically to treat infections caused by both multiple drug-resistant (MDR) Gram-negative and Gram-positive bacteria. Resistance to this drug is often caused by chromosome-encoding m...... hiện toàn bộ
Single swim sessions in C. elegans induce key features of mammalian exercise
BMC Biology - Tập 15 - Trang 1-17 - 2017
Ricardo Laranjeiro, Girish Harinath, Daniel Burke, Bart P. Braeckman, Monica Driscoll
Exercise exerts remarkably powerful effects on metabolism and health, with anti-disease and anti-aging outcomes. Pharmacological manipulation of exercise benefit circuits might improve the health of the sedentary and the aging populations. Still, how exercised muscle signals to induce system-wide health improvement remains poorly understood. With a long-term interest in interventions that promote ...... hiện toàn bộ
Proteasome inhibition, the pursuit of new cancer therapeutics, and the adaptor molecule p130Cas
BMC Biology - Tập 9 Số 1 - 2011
Dharminder Chauhan, Kenneth C. Anderson
Ubiquitylation is required for the incorporation of the Notch receptor into intraluminal vesicles to prevent prolonged and ligand-independent activation of the pathway
BMC Biology - Tập 20 - Trang 1-25 - 2022
Björn Schnute, Hideyuki Shimizu, Marvin Lyga, Martin Baron, Thomas Klein
Ubiquitylation of the ligands and the receptor plays an important part in the regulation of the activity of the evolutionary conserved Notch signalling pathway. However, its function for activation of Notch is not completely understood, despite the identification of several E3 ligases devoted to the receptor. Here we analysed a variant of the Notch receptor where all lysines in its intracellular d...... hiện toàn bộ
Additive contributions of melanopsin and both cone types provide broadband sensitivity to mouse pupil control
BMC Biology - Tập 16 - Trang 1-24 - 2018
Edward A. Hayter, Timothy M. Brown
Intrinsically photosensitive retinal ganglion cells (ipRGCs) drive an array of non-image-forming (NIF) visual responses including circadian photoentrainment and the pupil light reflex. ipRGCs integrate extrinsic (rod/cone) and intrinsic (melanopsin) photoreceptive signals, but the contribution of cones to ipRGC-dependent responses remains incompletely understood. Given recent data revealing that c...... hiện toàn bộ
Time-resolved dual transcriptomics reveal early induced Nicotiana benthamiana root genes and conserved infection-promoting Phytophthora palmivora effectors
BMC Biology - - 2017
Édouard Evangelisti, Anna Gogleva, Thomas Hainaux, Mehdi Doumane, Frej Tulin, ClĂŠment Quan, T. S. Yunusov, Kévin Floch, Sebastián Schornack
Rapid identification of mosquito species and age by mass spectrometric analysis
BMC Biology - Tập 21 - Trang 1-20 - 2023
Iris Wagner, Linda Grigoraki, Peter Enevoldson, Michael Clarkson, Sam Jones, Jane L. Hurst, Robert J. Beynon, Hilary Ranson
A rapid, accurate method to identify and to age-grade mosquito populations would be a major advance in predicting the risk of pathogen transmission and evaluating the public health impact of vector control interventions. Whilst other spectrometric or transcriptomic methods show promise, current approaches rely on challenging morphological techniques or simple binary classifications that cannot ide...... hiện toàn bộ
What are karrikins and how were they ‘discovered’ by plants?
BMC Biology - Tập 13 Số 1 - 2015
Gavin R. Flematti, Kingsley W. Dixon, Steven M. Smith
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