Arthritis and Rheumatology

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Interferon Regulatory Factor 1 Marks Activated Genes and Can Induce Target Gene Expression in Systemic Lupus Erythematosus
Arthritis and Rheumatology - Tập 67 Số 3 - Trang 785-796 - 2015
Zhe Zhang, Lihua Shi, Li Song, Elshaddai Ephrem, Michelle Petri, Kathleen E. Sullivan
ObjectiveInterferon regulatory factor 1 (IRF‐1) mediates both induction of interferons (IFNs) and responses to type I IFNs. It has been implicated as a critical mediator of inflammation in murine lupus models. In a previous study of chromatin modifications in monocytes from patients with systemic lupus erythematosus (SLE), IRF‐1 was implicated as being associated with increased histone acetylation... hiện toàn bộ
Brief Report: IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross‐Disease Meta‐Analysis of Genome‐Wide Association Studies
Arthritis and Rheumatology - Tập 68 Số 9 - Trang 2338-2344 - 2016
Elena López‐Isac, Javier Martı́n, Shervin Assassi, Carmen Pilar Simeón‐Aznar, Patrícia Carreira, Norbérto Ortego-Centeno, M. Freire, E. Beltrán, Javier Narváez, Juan José Alegre Sancho, Antonio Fernández‐Nebro, Alejandro Balsa, Ana M. Ortiz, Miguel Á. González‐Gay, Lorenzo Beretta, Alessandro Santaniello, Chiara Bellocchi, Claudio Lunardi, Gianluca Moroncini, Tianlu Li, Torsten Witte, Nicolas Hunzelmann, Jörg H. W. Distler, Gabriella Riekemasten, Annette H M van der Helm–van Mil, Jeska de Vries‐Bouwstra, César Magro‐Checa, Alexandre E. Voskuyl, Alfredo Castillo, Øyvind Molberg, Tony R. Merriman, Roger Hesselstrand, Annica Nordin, Leonid Padyukov, Ariane L. Herrick, Stephen E. Epstein, Christopher P. Denton, Carmen Fonseca, Timothy R. D. J. Radstake, Jane Worthington, Maureen D. Mayes
ObjectiveSystemic sclerosis (SSc) and rheumatoid arthritis (RA) are autoimmune diseases that have similar clinical and immunologic characteristics. To date, several shared SSc–RA genetic loci have been identified independently. The aim of the current study was to systematically search for new common SSc–RA loci through an interdisease meta–genome‐wide association (meta‐GWAS) strategy.MethodsThe st... hiện toàn bộ
Genome‐Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture
Arthritis and Rheumatology - Tập 68 Số 4 - Trang 932-943 - 2016
Marta E. Alarcón‐Riquelme, Julie T. Ziegler, Julio E. Molineros, Timothy D. Howard, Andrés Moreno‐Estrada, Elena Sánchez, Hannah C. Ainsworth, Patricia A. Ortiz-Tello, Mary E. Comeau, Astrid Rasmussen, Jennifer A. Kelly, Adam Adler, Eduardo Acevedo, Jorge M. Cucho‐Venegas, Ignacio García‐De La Torre, Mario H. Cardiel, Pedro C. Miranda, Luís J. Catoggio, Marco A. Maradiaga‐Ceceña, Patrick M. Gaffney, Timothy J. Vyse, Lindsey A. Criswell, Betty P. Tsao, Kathy L. Sivils, Sang‐Cheol Bae, Judith A. James, Robert P. Kimberly, Kenneth M. Kaufman, Joel M. Guthridge, Andrew Whelton, J. F. Moctezuma, Mercedes García, Guillermo Berbotto, Alejandra Babini, Hugo R Scherbarth, Sergio Toloza, Vicente Baca, Swapan K. Nath, Carlos A. Aguilar‐Salinas, Lorena Orozco, Teresa Tusié‐Luna, Raphael Zidovetzki, Bernardo A. Pons‐Estel, Carl D. Langefeld, Chaim O. Jacob
ObjectiveSystemic lupus erythematosus (SLE) is a chronic autoimmune disease with a strong genetic component. We undertook the present work to perform the first genome‐wide association study on individuals from the Americas who are enriched for Native American heritage.MethodsWe analyzed 3,710 individuals from the US and 4 countries of Latin America who were diagnosed as having SLE, and healthy con... hiện toàn bộ
2016 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjögren's Syndrome: A Consensus and Data‐Driven Methodology Involving Three International Patient Cohorts
Arthritis and Rheumatology - Tập 69 Số 1 - Trang 35-45 - 2017
Caroline H. Shiboski, Stephen Shiboski, Raphaèle Séror, Lindsey A. Criswell, Marc Labétoulle, Thomas M. Lietman, Astrid Rasmussen, R. Hal Scofield, Claudio Vitali, Simon Bowman, Xavier Mariette
ObjectiveTo develop and validate an international set of classification criteria for primary Sjögren's syndrome (SS) using guidelines from the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). These criteria were developed for use in individuals with signs and/or symptoms suggestive of SS.MethodsWe assigned preliminary importance weights to a consensus list... hiện toàn bộ
Histologic and Transcriptional Evidence of Subclinical Synovial Inflammation in Patients With Rheumatoid Arthritis in Clinical Remission
Arthritis and Rheumatology - Tập 71 Số 7 - Trang 1034-1041 - 2019
Dana E. Orange, Phaedra Agius, Edward F. DiCarlo, Serene Z. Mirza, Tania Pannellini, Jackie Szymonifka, Caroline S. Jiang, Mark P. Figgie, Mayu O. Frank, William H. Robinson, Laura T. Donlin, Cristina Rozo, Ellen M. Gravallese, Vivian P. Bykerk, Susan M. Goodman
ObjectivePatients with rheumatoid arthritis (RA) in clinical remission may have subclinical synovial inflammation. This study was undertaken to determine the proportion of patients with RA in remission or with low disease activity at the time of arthroplasty who had histologic or transcriptional evidence of synovitis, and to identify clinical features that distinguished patients as having subclini... hiện toàn bộ
Nonsteroidal Antiinflammatory Drugs and Susceptibility to COVID‐19
Arthritis and Rheumatology - Tập 73 Số 5 - Trang 731-739 - 2021
Joht Singh Chandan, Dawit T. Zemedikun, Rasiah Thayakaran, Nathan Byne, Samir Dhalla, Dionisio Acosta, Krishna Gokhale, Tom Thomas, Christopher Sainsbury, Anuradhaa Subramanian, Jennifer Cooper, Astha Anand, Kelvin Okoth, Jingya Wang, Nicola J. Adderley, Thomas Taverner, Alastair K. Denniston, Janet M. Lord, G. Neil Thomas, Christopher D. Buckley, Karim Raza, Neeraj Bhala, Krishnarajah Nirantharakumar, Shamil Haroon
ObjectiveTo identify whether active use of nonsteroidal antiinflammatory drugs (NSAIDs) increases susceptibility to developing suspected or confirmed coronavirus disease 2019 (COVID‐19) compared to the use of other common analgesics.MethodsWe performed a propensity score–matched cohort study with active comparators, using a large UK primary care data set. The cohort consisted of adult patients age... hiện toàn bộ
Brief Report: Leg Length Inequality and Hip Osteoarthritis in the Multicenter Osteoarthritis Study and the Osteoarthritis Initiative
Arthritis and Rheumatology - Tập 70 Số 10 - Trang 1572-1576 - 2018
Chan Kim, Michael C. Nevitt, Ali Guermazi, Jingbo Niu, Margaret Clancy, Irina Tolstykh, Pia M. Jungmann, Nancy E. Lane, Neil A. Segal, William F. Harvey, Cora E. Lewis, David T. Felson
ObjectiveStudies suggest that persons with a leg length inequality (LLI) of ≥2 cm have an increased risk of developing knee osteoarthritis (OA) in that limb. The present study was undertaken to examine whether LLI also confers an increased risk of hip OA.MethodsUsing long limb radiographs from subjects in the Multicenter Arthritis Study (MOST) and the Osteoarthritis Initiative (OAI), we measured L... hiện toàn bộ
Interleukin‐23–Dependent γ/δ T Cells Produce Interleukin‐17 and Accumulate in the Enthesis, Aortic Valve, and Ciliary Body in Mice
Arthritis and Rheumatology - Tập 68 Số 10 - Trang 2476-2486 - 2016
Annika Reinhardt, Tetyana Yevsa, Tim Worbs, Stefan Lienenklaus, Inga Sandrock, Linda Oberdörfer, Thomas Korn, Siegfried Weiß, Reinhold Förster, Immo Prinz
ObjectiveThe spondyloarthritides (SpA) are a group of rheumatic diseases characterized by ossification and inflammation of entheseal tissue, the region where tendon attaches to bone. Interleukin‐23 (IL‐23) is involved in the pathogenesis of SpA by acting on IL‐23 receptor (IL‐23R) expressed on enthesis‐resident lymphocytes. Upon IL‐23 binding, CD3+CD4−CD8− tissue‐resident lymphocytes secrete IL‐17... hiện toàn bộ
Inhibition of Natural Killer Cell Cytotoxicity by Interleukin‐6: Implications for the Pathogenesis of Macrophage Activation Syndrome
Arthritis and Rheumatology - Tập 67 Số 11 - Trang 3037-3046 - 2015
Loredana Cifaldi, Giusi Prencipe, Ivan Caiello, Claudia Bracaglia, Franco Locatelli, Fabrizio De Benedetti, Raffaele Strippoli
ObjectiveSystemic juvenile idiopathic arthritis (JIA) is associated with high levels of interleukin‐6 (IL‐6) in the serum and synovial fluid, and impairment of natural killer (NK) cell function is often observed. This study was undertaken to evaluate a possible link between these 2 biologic findings and whether they may be associated with the development of macrophage activation syndrome, a condit... hiện toàn bộ
Review: Synovial Cell Metabolism and Chronic Inflammation in Rheumatoid Arthritis
Arthritis and Rheumatology - Tập 70 Số 7 - Trang 984-999 - 2018
Jane Falconer, Anne N. Murphy, Stephen P. Young, Andrew R. Clark, Stefano Tiziani, Mònica Gumà, Christopher D. Buckley
Metabolomic studies of body fluids show that immune‐mediated inflammatory diseases such as rheumatoid arthritis (RA) are associated with metabolic disruption. This is likely to reflect the increased bioenergetic and biosynthetic demands of sustained inflammation and changes in nutrient and oxygen availability in damaged tissue. The synovial membrane lining layer is the principal site of inflammati... hiện toàn bộ
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