Archives of Disease in Childhood: Fetal and Neonatal Edition
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Cognitive assessment of children at age 2½ years after maternal fish oil supplementation in pregnancy: a randomised controlled trial Objective: To assess the effects of antenatal omega 3 long-chain polyunsaturated fatty acid (n-3 LC PUFA) on cognitive development in a cohort of children whose mothers received high-dose fish oil in pregnancy. Design: A double-blind randomised placebo-controlled trial. Setting: Perth, Western Australia, Australia. Patients: 98 pregnant women received the supplementation from 20 weeks’ gestation until delivery. Their infants (n = 72) were assessed at age 2½ years. Interventions: Fish oil (2.2 g docosahexaenoic acid (DHA) and 1.1 g eicosapentaenoic acid (EPA)/day) or olive oil from 20 weeks’ gestation until delivery. Outcome measures: Effects on infant growth and developmental quotients (Griffiths Mental Development Scales), receptive language (Peabody Picture Vocabulary Test) and behaviour (Child Behaviour Checklist). Results: Children in the fish oil-supplemented group (n = 33) attained a significantly higher score for eye and hand coordination (mean ((SD) score 114 (10.2)) than those in the placebo group (n = 39, mean score 108 (SD 11.3); p = 0.021, adjusted p = 0.008). Eye and hand coordination scores correlated with n-3 PUFA levels in cord blood erythrocytes (EPA: r = 0.320, p = 0.007; DHA: r = 0.308, p = 0.009) and inversely correlated with n-6 PUFA (arachidonic acid 20:4n-6: r = −0.331, p = 0.005). Growth measurements in the two groups were similar at age 2½ years. Conclusion: Maternal fish oil supplementation during pregnancy is safe for the fetus and infant, and may have potentially beneficial effects on the child’s eye and hand coordination. Further studies are needed to determine the significance of this finding.
Archives of Disease in Childhood: Fetal and Neonatal Edition - Tập 93 Số 1 - Trang F45-F50 - 2008
Mannose-binding lectin and infection risk in newborns: a systematic review
Archives of Disease in Childhood: Fetal and Neonatal Edition - Tập 95 Số 6 - Trang F452-F461 - 2010
Concentrations of main serum opsonins in early infancy.
Archives of Disease in Childhood: Fetal and Neonatal Edition - Tập 72 Số 3 - Trang F172-F175 - 1995
An assessment of pancreatic endocrine function and insulin sensitivity in patients with transient neonatal diabetes in remission
Archives of Disease in Childhood: Fetal and Neonatal Edition - Tập 89 Số 4 - Trang F341-F343 - 2004
X-linked immune dysregulation, neonatal insulin dependent diabetes, and intractable diarrhoea.
Archives of Disease in Childhood: Fetal and Neonatal Edition - Tập 74 Số 3 - Trang F195-F199 - 1996
Recovery of amplitude integrated electroencephalographic background patterns within 24 hours of perinatal asphyxia
Archives of Disease in Childhood: Fetal and Neonatal Edition - Tập 90 Số 3 - Trang F245-f251 - 2005
Effect of dexamethasone on IL-2 and IL-3 production by mononuclear cells in neonates and adults.
Archives of Disease in Childhood: Fetal and Neonatal Edition - Tập 75 Số 3 - Trang F197-F201 - 1996
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