Annual Review of Biochemistry
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The Molecular Basis of G Protein–Coupled Receptor Activation G protein–coupled receptors (GPCRs) mediate the majority of cellular responses to external stimuli. Upon activation by a ligand, the receptor binds to a partner heterotrimeric G protein and promotes exchange of GTP for GDP, leading to dissociation of the G protein into α and βγ subunits that mediate downstream signals. GPCRs can also activate distinct signaling pathways through arrestins.... ... hiện toàn bộ
Annual Review of Biochemistry - Tập 87 Số 1 - Trang 897-919 - 2018
Reversal of Histone Methylation: Biochemical and Molecular Mechanisms of Histone Demethylases The importance of histone methylation in gene regulation was suggested over 40 years ago. Yet, the dynamic nature of this histone modification was recognized only recently, with the discovery of the first histone demethylase nearly five years ago. Since then, our insight into the mechanisms, structures, and macromolecular complexes of these enzymes has grown exponentially. Overall, the ev... ... hiện toàn bộ
Annual Review of Biochemistry - Tập 79 Số 1 - Trang 155-179 - 2010
THE MAMMALIAN UNFOLDED PROTEIN RESPONSE ▪ Abstract In the endoplasmic reticulum (ER), secretory and transmembrane proteins fold into their native conformation and undergo posttranslational modifications important for their activity and structure. When protein folding in the ER is inhibited, signal transduction pathways, which increase the biosynthetic capacity and decrease the biosynthetic burden of the ER to maintain the home... ... hiện toàn bộ
Annual Review of Biochemistry - Tập 74 Số 1 - Trang 739-789 - 2005
Protein Disulfide Bond Formation in Prokaryotes ▪ Abstract Disulfide bonds formed between pairs of cysteines are important features of the structure of many proteins. Elaborate electron transfer pathways have evolved Escherichia coli to promote the formation of these covalent bonds and to ensure that the correct pairs of cysteines are joined in the final folded protein. These transfers of electrons consist, in the main, of cascades of... ... hiện toàn bộ
Annual Review of Biochemistry - Tập 72 Số 1 - Trang 111-135 - 2003
Transcript Elongation by RNA Polymerase II Until recently, it was generally assumed that essentially all regulation of transcription takes place via regions adjacent to the coding region of a gene—namely promoters and enhancers—and that, after recruitment to the promoter, the polymerase simply behaves like a machine, quickly “reading the gene.” However, over the past decade a revolution in this thinking has occurred, culminating i... ... hiện toàn bộ
Annual Review of Biochemistry - Tập 79 Số 1 - Trang 271-293 - 2010
Enjoy the Trip: Calcium in Mitochondria Back and Forth In the last 5 years, most of the molecules that control mitochondrial Ca2+ homeostasis have been finally identified. Mitochondrial Ca2+ uptake is mediated by the Mitochondrial Calcium Uniporter (MCU) complex, a macromolecular structure that guarantees Ca2+ accumulation inside mitochondrial matrix upon increases in cytosolic Ca... ... hiện toàn bộ
Annual Review of Biochemistry - Tập 85 Số 1 - Trang 161-192 - 2016
Empirical Predictions of Protein Conformation
Annual Review of Biochemistry - Tập 47 Số 1 - Trang 251-276 - 1978
Chromosomal Proteins and Chromatin Structure
Annual Review of Biochemistry - Tập 44 Số 1 - Trang 725-774 - 1975
The Biochemistry of Learning: An Evaluation of the Role of RNA and Protein
Annual Review of Biochemistry - Tập 38 Số 1 - Trang 605-646 - 1969
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