Free Radicals and Antioxidants in the Year 2000: A Historical Look to the FutureAnnals of the New York Academy of Sciences - Tập 899 Số 1 - Trang 136-147 - 2000
John M.C. Gutteridge, Barry Halliwell
Abstract:In the late 1950's free radicals and antioxidants were almost unheard of in the clinical and biological sciences but chemists had known about them for years in the context of radiation, polymer and combustion technology. Daniel Gilbert, Rebeca Gerschman and their colleagues related the toxic effects of elevated oxygen levels on aerobes to ...... hiện toàn bộ
Mechanism of Action of CamptothecinAnnals of the New York Academy of Sciences - Tập 922 Số 1 - Trang 1-10 - 2000
Leroy F. Liu, Shyamal D. Desai, Tsai‐Kun Li, Yong Mao, Mei Sun, Sai-Peng Sim
Abstract: Camptothecin (CPT) class of compounds has been demonstrated to be effective against a broad spectrum of tumors. Their molecular target has been firmly established to be human DNA topoisomerase I (topo I). CPT inhibits topo I by blocking the rejoining step of the cleavage/religation reaction of topo‐I, resulting in accumulation of a coval...... hiện toàn bộ
Structural Magnetic Resonance Imaging of the Adolescent BrainAnnals of the New York Academy of Sciences - Tập 1021 Số 1 - Trang 77-85 - 2004
Jay N. Giedd
Abstract: Magnetic resonance imaging (MRI) provides accurate anatomical brain images without the use of ionizing radiation, allowing longitudinal studies of brain morphometry during adolescent development. Results from an ongoing brain imaging project being conducted at the Child Psychiatry Branch of the National Institute of Mental Health indicat...... hiện toàn bộ
TRAIL‐Induced ApoptosisAnnals of the New York Academy of Sciences - Tập 1171 Số 1 - Trang 50-58 - 2009
Nadia Corazza, Daniela Kassahn, Sabine Jakob, A Badmann, Thomas Brunner
The death ligand members of the tumor necrosis factor (TNF) family are potent inducers of apoptosis in a variety of cell types. In particular, TNF‐related apoptosis‐inducing ligand (TRAIL) has recently received much scientific and commercial attention because of its potent tumor cell‐killing activity while leaving normal untransformed cells mostly unaffected. Furthermore, TRAIL strongly sy...... hiện toàn bộ