Annals of the New York Academy of Sciences
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Free Radicals and Antioxidants in the Year 2000: A Historical Look to the Future
Annals of the New York Academy of Sciences - Tập 899 Số 1 - Trang 136-147 - 2000
Abstract:In the late 1950's free radicals and antioxidants were almost unheard
of in the clinical and biological sciences but chemists had known about them for
years in the context of radiation, polymer and combustion technology. Daniel
Gilbert, Rebeca Gerschman and their colleagues related the toxic effects of
elevated oxygen levels on aerobes to those of ionizing radiation, and proposed
that oxy...
A PERSPECTIVE ON THE APPLICATION OF GENETIC ENGINEERING: STABILITY OF RECOMBINANT PLASMID
Annals of the New York Academy of Sciences - Tập 369 Số 1 - Trang 1-14 - 1981
Mechanism of Action of Camptothecin
Annals of the New York Academy of Sciences - Tập 922 Số 1 - Trang 1-10 - 2000
Abstract: Camptothecin (CPT) class of compounds has been demonstrated to be
effective against a broad spectrum of tumors. Their molecular target has been
firmly established to be human DNA topoisomerase I (topo I). CPT inhibits topo I
by blocking the rejoining step of the cleavage/religation reaction of topo‐I,
resulting in accumulation of a covalent reaction intermediate, the cleavable
complex. T...
Mechanism of Action of Camptothecin
Annals of the New York Academy of Sciences - Tập 803 Số 1 - Trang 44-49 - 1996
THE RADIOIMMUNOASSAY OF HUMAN NEUROPHYSINS: CONTRIBUTION TO THE UNDERSTANDING OF THE PHYSIOPATHOLOGY OF NEUROHYPOPHYSEAL FUNCTION*
Annals of the New York Academy of Sciences - Tập 248 Số 1 - Trang 281-303 - 1975
Neovascularization in the Abdominal Aortic Aneurysm
Annals of the New York Academy of Sciences - Tập 800 Số 1 - Trang 277-277 - 1996
Anti–CTLA‐4 synergizes with dendritic cell–targeted vaccine to promote IL‐3–dependent CD4+ effector T cell infiltration into murine pancreatic tumors
Annals of the New York Academy of Sciences - Tập 1445 Số 1 - Trang 62-73 - 2019
AbstractOne successful class of cancer immunotherapies, immune checkpoint
inhibitory antibodies, disrupts key pathways that regulate immune checkpoints,
such as cytotoxic T lymphocyte–associated antigen‐4 (CTLA‐4). These agents
unleash the potency of antigen‐experienced T cells that have already been
induced as a consequence of the existing tumor. But only 20% of cancers
naturally induce T cells. ...
Structural Magnetic Resonance Imaging of the Adolescent Brain
Annals of the New York Academy of Sciences - Tập 1021 Số 1 - Trang 77-85 - 2004
Abstract: Magnetic resonance imaging (MRI) provides accurate anatomical brain
images without the use of ionizing radiation, allowing longitudinal studies of
brain morphometry during adolescent development. Results from an ongoing brain
imaging project being conducted at the Child Psychiatry Branch of the National
Institute of Mental Health indicate dynamic changes in brain anatomy throughout
adole...
Role of Nitric Oxide in Endotoxic Shocka: An Overview of Recent Advances
Annals of the New York Academy of Sciences - Tập 851 Số 1 STRESS OF LIF - Trang 422-425 - 1998
TRAIL‐Induced Apoptosis
Annals of the New York Academy of Sciences - Tập 1171 Số 1 - Trang 50-58 - 2009
The death ligand members of the tumor necrosis factor (TNF) family are potent
inducers of apoptosis in a variety of cell types. In particular, TNF‐related
apoptosis‐inducing ligand (TRAIL) has recently received much scientific and
commercial attention because of its potent tumor cell‐killing activity while
leaving normal untransformed cells mostly unaffected. Furthermore, TRAIL
strongly synergizes...
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