Annals of Hematology
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Cyclosporin A in aplastic anemia — report of a workshop
Annals of Hematology - Tập 65 - Trang 33-36 - 1992
The management of aplastic anemia continues to challenge clinical investigators. With bone marrow transplantation or immunosuppression the prognosis of the patient with aplastic anemia has improved remarkably. For patients who are not eligible for bone marrow transplantation, antilymphocyte globulin has become the standard treatment. There is growing evidence that some patients also respond to imm...... hiện toàn bộ
Một chất ức chế phân tử nhỏ Bcl-2 mới 4-(3-methoxy-phenylsulfannyl)-7-nitro-benzofurazan-3-oxide (MNB) gây ra hiện tượng apoptosis trong các tế bào leukemia Dịch bởi AI
Annals of Hematology - Tập 86 - Trang 471-481 - 2007
Một chất ức chế phân tử nhỏ mới, 4-(3-methoxy-phenylsulfannyl)-7-nitro-benzofurazan-3-oxide (MNB), cạnh tranh với peptide Bak BH3 để gắn vào protein Bcl-2 với độ ái lực gắn kết IC50 = 0.70 μM, được đánh giá bằng cách thử nghiệm gắn kết dựa trên phân cực huỳnh quang. Tế bào HL-60 có mức độ biểu hiện Bcl-2 cao nhất trong số các dòng tế bào được kiểm tra. Khi được điều trị với 5 μM MNB trong 6 giờ, 8...... hiện toàn bộ
#Bcl-2 #chất ức chế phân tử nhỏ #MNB #apoptosis #tế bào HL-60 #caspase #bệnh bạch cầu
High-dose etoposide could discriminate the benefit from autologous peripheral blood stem cell transplantation in the patients with refractory diffuse large B cell lymphoma
Annals of Hematology - Tập 98 - Trang 823-831 - 2019
To evaluate the strategy of using high-dose etoposide mobilization followed by autologous peripheral blood stem cell transplantation (APBSCT) in patients with diffuse large B cell lymphoma (DLBCL) refractory to rituximab-based chemotherapy. Forty patients with refractory DLBCL were treated with high-dose etoposide for stem cell mobilization. All patients were in progressive disease (PD) prior to m...... hiện toàn bộ
An ABO-blood group abnormality leading to the detection of a colon-carcinoma
Annals of Hematology - Tập 46 - Trang 161-164 - 1983
A patient who had been admitted to hospital for surgical treatment of inguinal hernias was found to have a blood group phenotype of A1B in the presence of a non-auto-anti-B. No previous records of the patient's blood group were available. The serological workup including absorption and saliva inhibiton studies yielded a high probability for an acquired B-antigen which is known to be often associat...... hiện toàn bộ
Widening the spectrum of deletions and molecular mechanisms underlying alpha-thalassemia
Annals of Hematology - Tập 96 - Trang 1921-1929 - 2017
Inherited deletions of α-globin genes and/or their upstream regulatory elements (MCSs) give rise to α-thalassemia, an autosomal recessive microcytic hypochromic anemia. In this study, multiplex ligation-dependent probe amplification performed with commercial and synthetic engineered probes, Gap-PCR, and DNA sequencing were used to characterize lesions in the sub-telomeric region of the short arm o...... hiện toàn bộ
Functional inhibition of BCL2 is needed to increase the susceptibility to apoptosis to SMO inhibitors in diffuse large B-cell lymphoma of germinal center subtype
Annals of Hematology - Tập 92 Số 6 - Trang 777-787 - 2013
Failure of repeated courses of high-dose intravenous immunoglobulin to induce stable remission in patients with chronic idiopathic thrombocytopenic purpura
Annals of Hematology - Tập 70 - Trang 89-90 - 1995
Repeated courses of HD IVIg are reported to induce stable remission in a significant proportion of adults with chronic refractory ITP. We have treated 14 such patients obtaining a remission rate quite comparable to the 5–10% of spontaneous remission.
Distribution of ABO blood groups in acute leukaemias and lymphomas
Annals of Hematology - Tập 83 - Trang 584-587 - 2004
We studied the distribution of ABO blood groups in Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, acute myeloid leukaemia and acute lymphoblastic leukaemia, in children up to the age of 12 years, in a hospital-based retrospective study. Blood group data were recorded from the case records of all the patients in a tertiary care centre with the diagnosis of Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, a...... hiện toàn bộ
Quality of life more impaired in younger than in older diffuse large B cell lymphoma survivors compared to a normative population: a study from the population-based PROFILES registry
Annals of Hematology - Tập 93 - Trang 811-819 - 2013
The objective of this study was to compare health-related quality of life (HRQOL) between diffuse large B cell lymphoma (DLBCL) survivors of different age categories (18–59/60–75/76–85 years) and to compare their HRQOL with an age- and sex-matched normative population. The population-based Eindhoven Cancer Registry was used to select all patients diagnosed with DLBCL from 1999 to 2010. Patients (n...... hiện toàn bộ
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