Angiogenesis

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Serum and plasma levels of FGF-2 and VEGF in healthy blood donors
Angiogenesis - Tập 5 - Trang 107-110 - 2002
A. Larsson, E. Sköldenberg, H. Ericson
VEGF-A and FGF-2 are two angiogenic growth factors involved in the growth and invasion of solid tumours and haematological malignancies. They are also believed to play an important role in cardiovascular and inflammatory diseases. Several studies dealing with measurement of circulating FGF-2 and VEGF have been published during the last decade. We have studied the levels of FGF-2 and VEGF-A in seru...... hiện toàn bộ
Peroxisome Proliferator Activated Receptor-γ (PPAR-γ) Ligands and Angiogenesis
Angiogenesis - Tập 6 - Trang 165-169 - 2003
A. Margeli, G. Kouraklis, S. Theocharis
The peroxisome proliferator activated receptor (PPAR)-γ ligands have been initially described as important regulators of adipogenic differentiation and glucose homeostasis. Detailed studies in different tissues pointed to the roles of these ligands in cell proliferation and cancer, establishing their anticancer properties against a wide variety of neoplastic cells. The growth of any solid tumor de...... hiện toàn bộ
Cyclooxygenase inhibition in early onset of tumor growth and related angiogenesis evaluated in EP1 and EP3 knockout tumor-bearing mice
Angiogenesis - Tập 8 - Trang 339-348 - 2006
Hans Axelsson, Christina Lönnroth, Wenhua Wang, Elisabeth Svanberg, Kent Lundholm
It is well established that prostanoids are essential for local inflammation including cell proliferation and apoptosis. Accordingly, prostaglandin E2 (PGE2) is a critical factor in wound healing, tumor invasiveness and progression. Therefore, the aim of the present work was to evaluate effects by PGE2 on tumor vascular density at early onset of tumor growth where hypoxia is limited. Wild-type mic...... hiện toàn bộ
The HGR motif is the antiangiogenic determinant of vasoinhibin: implications for a therapeutic orally active oligopeptide
Angiogenesis - Tập 25 - Trang 57-70 - 2021
Juan Pablo Robles, Magdalena Zamora, Lourdes Siqueiros-Marquez, Elva Adan-Castro, Gabriela Ramirez-Hernandez, Francisco Freinet Nuñez, Fernando Lopez-Casillas, Robert P. Millar, Thomas Bertsch, Gonzalo Martínez de la Escalera, Jakob Triebel, Carmen Clapp
The hormone prolactin acquires antiangiogenic and antivasopermeability properties after undergoing proteolytic cleavage to vasoinhibin, an endogenous prolactin fragment of 123 or more amino acids that inhibits the action of multiple proangiogenic factors. Preclinical and clinical evidence supports the therapeutic potential of vasoinhibin against angiogenesis-related diseases including diabetic ret...... hiện toàn bộ
Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways
Angiogenesis - Tập 15 - Trang 421-432 - 2012
Yajuan Song, Fujun Dai, Dong Zhai, Yanmin Dong, Jing Zhang, Binbin Lu, Jian Luo, Mingyao Liu, Zhengfang Yi
Tumor growth depends on angiogenesis and inducing angiogenesis is one of the most important hallmarks in the cancer development. Treatment with small molecules that inhibit angiogenesis has been an effective strategy for anti-cancer therapy. Some anti-angiogenic factors are derived from traditional Chinese herbs. Usnic acid (UA), an active compound mainly found in lichens, has shown some biologica...... hiện toàn bộ
Endostatin and angiostatin: the next anti-angiogenesis generation
Angiogenesis - Tập 2 - Trang 25-27 - 1998
Elise C. Kohn
Increased Expression of VEGF-Receptors (FLT-1, KDR, NRP-1) and Thrombospondin-1 is Associated with Glomeruloid Microvascular Proliferation, an Aggressive Angiogenic Phenotype, in Malignant Melanoma
Angiogenesis - Tập 6 - Trang 295-301 - 2003
Oddbjørn Straume, Lars A. Akslen
Glomeruloid microvascular proliferations (GMPs), which are focal proliferative buddings of endothelial cells resembling a renal glomerulus, can be induced experimentally by adenoviral transfer of VEGF-A165. We recently found that GMPs were present in 13–23% of various human tumours (melanoma, breast-, endometrial- and prostate cancer), and this vascular signature was significantly associated with ...... hiện toàn bộ
Vegfr3-CreER T2 mouse, a new genetic tool for targeting the lymphatic system
Angiogenesis - Tập 19 - Trang 433-445 - 2016
Ines Martinez-Corral, Lukas Stanczuk, Maike Frye, Maria Helena Ulvmar, Rodrigo Diéguez-Hurtado, David Olmeda, Taija Makinen, Sagrario Ortega
The lymphatic system is essential in many physiological and pathological processes. Still, much remains to be known about the molecular mechanisms that control its development and function and how to modulate them therapeutically. The study of these mechanisms will benefit from better controlled genetic mouse models targeting specifically lymphatic endothelial cells. Among the genes expressed pred...... hiện toàn bộ
Angiogenic properties of myofibroblasts isolated from normal human skin wounds
Angiogenesis - Tập 15 - Trang 199-212 - 2012
Dominique Mayrand, Audrey Laforce-Lavoie, Sébastien Larochelle, Amélie Langlois, Hervé Genest, Michel Roy, Véronique J. Moulin
During wound healing, angiogenesis plays a crucial role in inducing adequate perfusion of the new tissue, thereby allowing its survival. This angiogenic process contributes to the formation of granulation tissue, alongside myofibroblasts. Myofibroblasts are cells specialized in wound contraction and synthesis of new extracellular matrix. Fibroblasts, considered by some to be at the origin of myofi...... hiện toàn bộ
From the editor
Angiogenesis - - 2008
Roy Bicknell, JR van Beijnum
Tổng số: 808   
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