Angiogenesis

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Peroxisome Proliferator Activated Receptor-γ (PPAR-γ) Ligands and Angiogenesis
Angiogenesis - Tập 6 - Trang 165-169 - 2003
A. Margeli, G. Kouraklis, S. Theocharis
The peroxisome proliferator activated receptor (PPAR)-γ ligands have been initially described as important regulators of adipogenic differentiation and glucose homeostasis. Detailed studies in different tissues pointed to the roles of these ligands in cell proliferation and cancer, establishing their anticancer properties against a wide variety of neoplastic cells. The growth of any solid tumor de...... hiện toàn bộ
Cyclooxygenase inhibition in early onset of tumor growth and related angiogenesis evaluated in EP1 and EP3 knockout tumor-bearing mice
Angiogenesis - Tập 8 - Trang 339-348 - 2006
Hans Axelsson, Christina Lönnroth, Wenhua Wang, Elisabeth Svanberg, Kent Lundholm
It is well established that prostanoids are essential for local inflammation including cell proliferation and apoptosis. Accordingly, prostaglandin E2 (PGE2) is a critical factor in wound healing, tumor invasiveness and progression. Therefore, the aim of the present work was to evaluate effects by PGE2 on tumor vascular density at early onset of tumor growth where hypoxia is limited. Wild-type mic...... hiện toàn bộ
Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways
Angiogenesis - Tập 15 - Trang 421-432 - 2012
Yajuan Song, Fujun Dai, Dong Zhai, Yanmin Dong, Jing Zhang, Binbin Lu, Jian Luo, Mingyao Liu, Zhengfang Yi
Tumor growth depends on angiogenesis and inducing angiogenesis is one of the most important hallmarks in the cancer development. Treatment with small molecules that inhibit angiogenesis has been an effective strategy for anti-cancer therapy. Some anti-angiogenic factors are derived from traditional Chinese herbs. Usnic acid (UA), an active compound mainly found in lichens, has shown some biologica...... hiện toàn bộ
Endostatin and angiostatin: the next anti-angiogenesis generation
Angiogenesis - Tập 2 - Trang 25-27 - 1998
Elise C. Kohn
Vegfr3-CreER T2 mouse, a new genetic tool for targeting the lymphatic system
Angiogenesis - Tập 19 - Trang 433-445 - 2016
Ines Martinez-Corral, Lukas Stanczuk, Maike Frye, Maria Helena Ulvmar, Rodrigo Diéguez-Hurtado, David Olmeda, Taija Makinen, Sagrario Ortega
The lymphatic system is essential in many physiological and pathological processes. Still, much remains to be known about the molecular mechanisms that control its development and function and how to modulate them therapeutically. The study of these mechanisms will benefit from better controlled genetic mouse models targeting specifically lymphatic endothelial cells. Among the genes expressed pred...... hiện toàn bộ
Angiogenic properties of myofibroblasts isolated from normal human skin wounds
Angiogenesis - Tập 15 - Trang 199-212 - 2012
Dominique Mayrand, Audrey Laforce-Lavoie, Sébastien Larochelle, Amélie Langlois, Hervé Genest, Michel Roy, Véronique J. Moulin
During wound healing, angiogenesis plays a crucial role in inducing adequate perfusion of the new tissue, thereby allowing its survival. This angiogenic process contributes to the formation of granulation tissue, alongside myofibroblasts. Myofibroblasts are cells specialized in wound contraction and synthesis of new extracellular matrix. Fibroblasts, considered by some to be at the origin of myofi...... hiện toàn bộ
From the editor
Angiogenesis - - 2008
Roy Bicknell, JR van Beijnum
Neuropilin-2 and vascular endothelial growth factor receptor-3 are up-regulated in human vascular malformations
Angiogenesis - Tập 16 - Trang 137-146 - 2012
Taina A. Partanen, Pia Vuola, Suvi Jauhiainen, Jouko Lohi, Päivi Salminen, Anne Pitkäranta, Sanna-Kaisa Häkkinen, Krista Honkonen, Kari Alitalo, Seppo Ylä-Herttuala
Despite multiple previous studies in the field of vascular anomalies, the mechanism(s) leading to their development, progression and maintenance has remained unclear. In this study, we have characterized the expression levels of vascular endothelial growth factors and their receptors in 33 human vascular anomalies. Analysis with quantitative real-time PCR and gene-specific assays showed higher exp...... hiện toàn bộ
Regulation of angiogenesis by microRNAs in cardiovascular diseases
Angiogenesis - Tập 21 - Trang 699-710 - 2018
Devika Kir, Erica Schnettler, Shrey Modi, Sundaram Ramakrishnan
Non-coding RNAs are functional RNA molecules comprising the majority of human transcriptome. Only about 1.5% of the human genome is transcribed into messenger RNAs (mRNA) that are translated into proteins. Among the non-coding RNAs, miRNAs are extensively studied and miR targets in endothelial cells, perivascular cells, and angiogenic signaling are relatively well defined. MicroRNAs not only regul...... hiện toàn bộ
Induction of membrane-type matrix metalloproteinase-1 stimulates angiogenic activities of bovine aortic endothelial cells
Angiogenesis - Tập 3 - Trang 167-174 - 1999
Joo-Won Jeong, Hee-Jae Cha, Dae-Yeul Yu, Motoharu Seiki, Kyu-Won Kim
Matrix metalloproteinases (MMPs) have been reported to play critical roles in endothelial cell migration and matrix remodeling during the angiogenic process. Among these MMPs, membrane-type MMP-1 (MT1-MMP) is an important molecule that can trigger the invasion of tumor cells by activating MMP-2 on their plasma membrane. However, the precise involvement of MT1-MMP in the angiogenic process has not ...... hiện toàn bộ
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