Angewandte Chemie - International Edition
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Alcohols in Isonitrile‐Based Multicomponent Reaction: Passerini Reaction of Alcohols in the Presence of <i>O</i>‐Iodoxybenzoic Acid
Angewandte Chemie - International Edition - Tập 45 Số 21 - Trang 3495-3497 - 2006
Multicomponent Reactions in Polymer Synthesis
Angewandte Chemie - International Edition - Tập 53 Số 1 - Trang 46-48 - 2014
Biocatalytic Oxidation Reactions: A Chemist's Perspective Abstract Oxidation chemistry using enzymes is approaching maturity and practical applicability in organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists to perform highly selective and efficient transformations ranging from simple alcohol oxidations to stereoselective halogenations of non‐activated C−H bonds. For many of these reactions, no “classical” chemical counterpart is known. Hence oxidoreductases open up shorter synthesis routes based on a more direct access to the target products. The generally very mild reaction conditions may also reduce the environmental impact of biocatalytic reactions compared to classical counterparts. In this Review, we critically summarise the most important recent developments in the field of biocatalytic oxidation chemistry and identify the most pressing bottlenecks as well as promising solutions.
Angewandte Chemie - International Edition - Tập 57 Số 30 - Trang 9238-9261 - 2018
Chemically Programmable and Switchable CAR‐T Therapy Abstract Although macromolecules on cell surfaces are predominantly targeted and drugged with antibodies, they harbor pockets that are only accessible to small molecules and constitutes a rich subset of binding sites with immense potential diagnostic and therapeutic utility. Compared to antibodies, however, small molecules are disadvantaged by a less confined biodistribution, shorter circulatory half‐life, and inability to communicate with the immune system. Presented herein is a method that endows small molecules with the ability to recruit and activate chimeric antigen receptor T cells (CAR‐Ts). It is based on a CAR‐T platform that uses a chemically programmed antibody fragment (cp‐Fab) as on/off switch. In proof‐of‐concept studies, this cp‐Fab/CAR‐T system targeting folate binding proteins on the cell surface mediated potent and specific eradication of folate‐receptor‐expressing cancer cells in vitro and in vivo.
Angewandte Chemie - International Edition - Tập 59 Số 29 - Trang 12178-12185 - 2020
PPy‐encapsulated SnS<sub>2</sub> Nanosheets Stabilized by Defects on a TiO<sub>2</sub> Support as a Durable Anode Material for Lithium‐Ion Batteries Abstract Nanostructured‐alloy‐type anodes have received great interest for high‐performance lithium‐ion batteries (LIBs). However, these anodes experience huge volume fluctuations during repeated lithiation/delithiation and are easily pulverized and subsequently form aggregates. Herein, an efficient method to stabilize alloy‐type anodes by creating defects on the surface of the metal oxide support is proposed. As a demonstration, PPy‐encapsulated SnS2 nanosheets supported on defect‐rich TiO2 nanotubes were produced and investigated as an anode material for LIBs. Both experimental results and theoretical calculations demonstrate that defect‐rich TiO2 provides more chemical adhesions to SnS2 and discharge products, compared to defect‐poor TiO2 , and then effectively stabilizes the electrode structure. As a result, the composite exhibits an unprecedented cycle stability. This work paves the way to designing durable and active nanostructured‐alloy‐type anodes on oxide supports.
Angewandte Chemie - International Edition - Tập 58 Số 3 - Trang 811-815 - 2019
Monoligated Palladium Species as Catalysts in Cross‐Coupling Reactions Abstract Palladium‐mediated cross‐coupling reactions are attractive organometallic transformations for the generation of CC, CN, CO, and CS bonds. Despite being widely employed in small‐scale syntheses, cross‐coupling reactions have not found important industrial applications because until recently, only reactive aryl bromides and iodides could be used as substrates. These substrates are generally more expensive and less widely available than their chloride counterparts. Over the past few years, new catalytic systems with the ability to activate unreactive and sterically hindered aryl chlorides have been developed. The new catalysts are based on palladium complexes that contain electron‐rich and bulky phosphine or carbene ligands. The enhanced reactivity observed with these new systems has been attributed to the formation of unsaturated and reactive [PdL] species which can readily undergo oxidative addition reactions with ArX to yield [Pd(Ar)X(L)].
Angewandte Chemie - International Edition - Tập 44 Số 3 - Trang 366-374 - 2005
Rational Ligand Design in Constructing Efficient Catalyst Systems for Suzuki–Miyaura Coupling
Angewandte Chemie - International Edition - Tập 43 Số 17 - Trang 2201-2203 - 2004
Iron‐Catalyzed C(sp<sup>2</sup>)H and C(sp<sup>3</sup>)H Arylation by Triazole Assistance Abstract Modular 1,2,3‐triazoles enabled iron‐catalyzed CH arylations with broad scope. The novel triazole‐based bidentate auxiliary is easily accessible in a highly modular fashion and allowed for user‐friendly iron‐catalyzed C(sp2 )H functionalizations of arenes and alkenes with excellent chemo‐ and diastereoselectivities. The versatile iron catalyst also proved applicable for challenging C(sp3 )H functionalizations, and proceeds by an organometallic mode of action. The triazole‐assisted CH activation strategy occurred under remarkably mild reaction conditions, and the auxiliary was easily removed in a traceless fashion. Intriguingly, the triazole group proved superior to previously used auxiliaries.
Angewandte Chemie - International Edition - Tập 53 Số 15 - Trang 3868-3871 - 2014
Versatile Reactivity of Rhodium–Iminocarbenes Derived from <i>N</i>‐Sulfonyl Triazoles
Angewandte Chemie - International Edition - Tập 52 Số 5 - Trang 1371-1373 - 2013
Subdiffraction‐Resolution Fluorescence Imaging with Conventional Fluorescent Probes
Angewandte Chemie - International Edition - Tập 47 Số 33 - Trang 6172-6176 - 2008
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