Analytical Chemistry is a peer-reviewed research journal that is devoted to the dissemination of new and original knowledge in all branches of analytical chemistry. Fundamental articles may address the general principles of chemical measurement science and need not directly address existing or potential analytical methodology. Articles may be entirely theoretical with regard to analysis, or they may report experimental results. They may contribute to any phase of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, microscale and nanoscale systems and structures, environmental analysis, separations, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers dealing with known analytical methods should offer a significant, original application of the method, a noteworthy improvement, or results on an important analyte. Research manuscripts include Letters, Technical Notes and Articles. Note that the maximum lengths of Letters, Technical Notes and articles are four, five and eight journal pages, respectively. In addition, the journal publishes Features and Perspectives. Feature articles are written for the generalist and are intended to broaden readers’ professional interests and keep them aware of the role of analytical chemistry in the scientific arena. Perspectives point out the authors’ vision of the character and importance of a new direction in analytical chemistry, analyze research reports that provide the foundation for the new direction, and discuss the nature of the opportunities perceived. See author guidelines for more information on the journal, the manuscript types, and how to estimate paper length.