American Society for Cell Biology (ASCB)
1044-2030
Cơ quản chủ quản: N/A
Các bài báo tiêu biểu
Mitogen-induced oscillations of cytosolic Ca2+ and transmembrane Ca2+ current in human leukemic T cells.
Tập 1 Số 1 - Trang 99-112 - 1989
A rapid rise in the level of cytosolic free calcium ([Ca2+]i) is believed to be
one of several early triggering signals in the activation of T lymphocytes by
antigen. Although Ca2+ release from intracellular stores and its contribution to
Ca2+ signaling in many cell types is well documented, relatively little is known
regarding the role and mechanism of Ca2+ entry across the plasma membrane. We
ha...
Comparison of Ca2+ mobilizing activities of cyclic ADP-ribose and inositol trisphosphate.
Tập 1 Số 3 - Trang 279-290 - 1990
We have previously shown that a metabolite of NAD+ generated by an enzyme
present in sea urchin eggs and mammalian tissues can mobilize intracellular Ca2+
in the eggs. Structural determination established it to be a cyclized
ADP-ribose, and the name cyclic ADP-ribose (cADPR) has been proposed. In this
study, Ca2+ mobilizations induced by cADPR and inositol trisphosphate (IP3) in
sea urchin egg hom...
Homologous and unique G protein alpha subunits in the nematode Caenorhabditis elegans.
Tập 2 Số 2 - Trang 135-154 - 1991
A cDNA corresponding to a known G protein alpha subunit, the alpha subunit of Go
(Go alpha), was isolated and sequenced. The predicted amino acid sequence of C.
elegans Go alpha is 80-87% identical to other Go alpha sequences. An mRNA that
hybridizes to the C. elegans Go alpha cDNA can be detected on Northern blots. A
C. elegans protein that crossreacts with antibovine Go alpha antibody can be
det...
Developmental regulation of calmodulin gene expression in rat brain and skeletal muscle.
Tập 2 Số 10 - Trang 819-826 - 1991
Three different calmodulin genes that encode the identical protein have been
identified in the rat (Nojima, 1989); however, calmodulin gene expression at the
various stages of tissue differentiation and maturation has not been previously
determined. We have quantitated the content of mRNAs encoding calmodulin in the
developing brain and skeletal muscle using RNA blot analysis with three specific
c...
Ca2+ inhibits guanine nucleotide-activated phospholipase D in neural-derived NG108-15 cells.
Tập 2 Số 12 - Trang 1011-1019 - 1991
We have investigated the regulation of phospholipase D (PLD) activity by guanine
nucleotides and Ca2+ in cells of the NG108-15 neuroblastoma X glioma line that
were permeabilized with digitonin. The nonhydrolyzable GTP analogue
guanosine-5'-O-(3-thiotriphosphate) (GTP gamma S) caused a nearly sixfold
increase (EC50 = 3 microM) in production of [3H]phosphatidylethanol (specific
product of the PLD t...
Regulatory functions of a non-ligand-binding thyroid hormone receptor isoform.
Tập 2 Số 7 - Trang 565-574 - 1991
Gene regulation by thyroid hormones is mediated through multiple nuclear
receptors. Only some of these thyroid hormone receptor (TR) isoforms become
transcriptional enhancers in the presence of the thyroid hormone T3. Here we
analyze the regulatory function of the human TR alpha 2 isoform. This protein
does not bind T3 and is not a transcriptional activator of thyroid
hormone-responsive elements (...