American Society for Cell Biology (ASCB)
1044-2030
Cơ quản chủ quản: N/A
Các bài báo tiêu biểu
Mitogen-induced oscillations of cytosolic Ca2+ and transmembrane Ca2+ current in human leukemic T cells. A rapid rise in the level of cytosolic free calcium ([Ca2+]i) is believed to be one of several early triggering signals in the activation of T lymphocytes by antigen. Although Ca2+ release from intracellular stores and its contribution to Ca2+ signaling in many cell types is well documented, relatively little is known regarding the role and mechanism of Ca2+ entry across the plasma membra... ...
Tập 1 Số 1 - Trang 99-112 - 1989
Comparison of Ca2+ mobilizing activities of cyclic ADP-ribose and inositol trisphosphate. We have previously shown that a metabolite of NAD+ generated by an enzyme present in sea urchin eggs and mammalian tissues can mobilize intracellular Ca2+ in the eggs. Structural determination established it to be a cyclized ADP-ribose, and the name cyclic ADP-ribose (cADPR) has been proposed. In this study, Ca2+ mobilizations induced by cADPR and inositol trisphosphate (IP3) in sea urchi... ...
Tập 1 Số 3 - Trang 279-290 - 1990
Homologous and unique G protein alpha subunits in the nematode Caenorhabditis elegans. A cDNA corresponding to a known G protein alpha subunit, the alpha subunit of Go (Go alpha), was isolated and sequenced. The predicted amino acid sequence of C. elegans Go alpha is 80-87% identical to other Go alpha sequences. An mRNA that hybridizes to the C. elegans Go alpha cDNA can be detected on Northern blots. A C. elegans protein that crossreacts with antibovine Go alpha antibody c... ...
Tập 2 Số 2 - Trang 135-154 - 1991
Developmental regulation of calmodulin gene expression in rat brain and skeletal muscle. Three different calmodulin genes that encode the identical protein have been identified in the rat (Nojima, 1989); however, calmodulin gene expression at the various stages of tissue differentiation and maturation has not been previously determined. We have quantitated the content of mRNAs encoding calmodulin in the developing brain and skeletal muscle using RNA blot analysis with three s... ...
Tập 2 Số 10 - Trang 819-826 - 1991
Ca2+ inhibits guanine nucleotide-activated phospholipase D in neural-derived NG108-15 cells. We have investigated the regulation of phospholipase D (PLD) activity by guanine nucleotides and Ca2+ in cells of the NG108-15 neuroblastoma X glioma line that were permeabilized with digitonin. The nonhydrolyzable GTP analogue guanosine-5'-O-(3-thiotriphosphate) (GTP gamma S) caused a nearly sixfold increase (EC50 = 3 microM) in production of [3H]phosphatidylethanol (specific product of ... ...
Tập 2 Số 12 - Trang 1011-1019 - 1991
Regulatory functions of a non-ligand-binding thyroid hormone receptor isoform. Gene regulation by thyroid hormones is mediated through multiple nuclear receptors. Only some of these thyroid hormone receptor (TR) isoforms become transcriptional enhancers in the presence of the thyroid hormone T3. Here we analyze the regulatory function of the human TR alpha 2 isoform. This protein does not bind T3 and is not a transcriptional activator of thyroid hormone-responsive e... ...
Tập 2 Số 7 - Trang 565-574 - 1991