American Journal of Physiology - Renal Physiology

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Albumin overload induces adaptive responses in human proximal tubular cells through oxidative stress but not via angiotensin II type 1 receptor
American Journal of Physiology - Renal Physiology - Tập 292 Số 6 - Trang F1846-F1857 - 2007
Liliana Shalamanova, Frank McArdle, Alieu Amara, Malcolm J. Jackson, Rana Rustom
Proteinuria is pathogenic to proximal tubular cells (PTC) and linked with progression to renal failure. The aim of this study was to determine the effects of human serum albumin (HSA) overload on the changes in gene and protein expression stimulated by oxidative stress in PTC and any interaction with ANG II that is pivotal in disease pathogenesis. Markers of oxidative stress, antioxidant d...... hiện toàn bộ
The Na+-Picotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi
American Journal of Physiology - Renal Physiology - Tập 296 Số 4 - Trang F691-F699 - 2009
Ricardo Villa‐Bellosta, Silvia Ravera, Vı́ctor Sorribas, Gerti Stange, Moshe Levi, Heini Murer, Jürg Biber, Ian C. Forster
The principal mediators of renal phosphate (Pi) reabsorption are the SLC34 family proteins NaPi-IIa and NaPi-IIc, localized to the proximal tubule (PT) apical membrane. Their abundance is regulated by circulatory factors and dietary Pi. Although their physiological importance has been confirmed in knockout animal studies, significant Pi... hiện toàn bộ
Critical roles of Sp1 in gene expression of human and rat H+/organic cation antiporter MATE1
American Journal of Physiology - Renal Physiology - Tập 293 Số 5 - Trang F1564-F1570 - 2007
Moto Kajiwara, Tomohiro Terada, Junichi Asaka, K. OGASAWARA, Toshiya Katsura, Osamu Ogawa, Atsushi Fukatsu, Toshio Doi, Ken‐ichi Inui
A H+/organic cation antiporter (multidrug and toxin extrusion 1: MATE1/SLC47A1) plays important roles in the tubular secretion of various clinically important cationic drugs such as cimetidine. We have recently found that the regulation of this transporter greatly affects the pharmacokinetic properties of cationic drugs in vivo. No information is available about the r...... hiện toàn bộ
Application of difference gel electrophoresis to the identification of inner medullary collecting duct proteins
American Journal of Physiology - Renal Physiology - Tập 286 Số 1 - Trang F170-F179 - 2004
Jason D. Hoffert, Bas W. M. van Balkom, Chung‐Lin Chou, Mark A. Knepper
In this study, we present a standardized approach to purification of native inner medullary collecting duct (IMCD) cells from rat kidney for proteomic analysis and apply the approach to identification of abundant proteins utilizing two-dimensional difference gel electrophoresis (DIGE) coupled with matrix-assisted laser desorption-ionization-time of flight mass spectrometry. Fractionation o...... hiện toàn bộ
A simplified method for HPLC determination of creatinine in mouse serum
American Journal of Physiology - Renal Physiology - Tập 286 Số 6 - Trang F1116-F1119 - 2004
Peter S. T. Yuen, Stephen Dunn, Toru Miyaji, Hideo Yasuda, Kumar Sharma, Robert A. Star
Mouse models are frequently used to study renal function. However, mouse serum contains chromagens that interfere with standard picric acid-based assays for serum creatinine. Several alternative methods exist for serum creatinine measurements, including assay by high-performance liquid chromatography (HPLC), but only one has been adapted to mouse serum. Creatinine was measured in serum by ...... hiện toàn bộ
FcRn-mediated transcytosis of immunoglobulin G in human renal proximal tubular epithelial cells
American Journal of Physiology - Renal Physiology - Tập 282 Số 2 - Trang F358-F365 - 2002
Noriyoshi Kobayashi, Yusuke Suzuki, Tomohiko Tsuge, Ko Okumura, Chisei Ra, Yasuhiko Tomino
In the kidney, proteins filtered through glomeruli are reabsorbed by endocytosis along the proximal tubules to avoid renal loss of large amounts of proteins. Recently, neonatal Fc receptor (FcRn), which is involved in the transport of IgG across several epithelial and endothelial cells, was reported to be expressed in renal proximal tubular epithelial cells (RPTECs). However, there has bee...... hiện toàn bộ
Aquaporin-2 localization in clathrin-coated pits: inhibition of endocytosis by dominant-negative dynamin
American Journal of Physiology - Renal Physiology - Tập 282 Số 6 - Trang F998-F1011 - 2002
Tian‐Xiao Sun, Alfred N. Van Hoek, Yan Huang, Richard Bouley, Margaret McLaughlin, Dennis Brown
Before the identification of aquaporin (AQP) proteins, vasopressin-regulated “water channels” were identified by freeze-fracture electron microscopy as aggregates or clusters of intramembraneous particles (IMPs) on hormonally stimulated target cell membranes. In the kidney collecting duct, these IMP clusters were subsequently identified as possible sites of clathrin-coated pit formation on...... hiện toàn bộ
Dynamics of aquaporin-2 serine-261 phosphorylation in response to short-term vasopressin treatment in collecting duct
American Journal of Physiology - Renal Physiology - Tập 292 Số 2 - Trang F691-F700 - 2007
Jason D. Hoffert, Jakob Nielsen, Ming‐Jiun Yu, Trairak Pisitkun, Stephen M. Schleicher, Søren Nielsen, Mark A. Knepper
We recently identified a novel phosphorylation site, serine-261 (pS261), in the COOH-terminus of the vasopressin-regulated water channel, aquaporin-2 (AQP2). To address whether phosphorylation at this site is regulated by vasopressin, a rabbit polyclonal phospho-specific antibody was generated. Dot blot and immunoblot analysis demonstrated that this antibody specifically recognizes AQP2 ph...... hiện toàn bộ
Methyl-β-cyclodextrin induces vasopressin-independent apical accumulation of aquaporin-2 in the isolated, perfused rat kidney
American Journal of Physiology - Renal Physiology - Tập 291 Số 1 - Trang F246-F253 - 2006
Leileata M. Russo, Mary McKee, Dennis Brown
Vasopressin increases urine concentration by stimulating plasma membrane accumulation of aquaporin-2 (AQP2) in collecting duct principal cells, allowing bulk water flow across the collecting duct from lumen to interstitium down an osmotic gradient. Mutations in the vasopressin type 2 receptor (V2R) cause hereditary X-linked nephrogenic diabetes insipidus (NDI), a disease characterized by ...... hiện toàn bộ
cAMP- and beta-adrenergic-stimulated chloride-dependent Ca2+ secretion in frog skin
American Journal of Physiology - Renal Physiology - Tập 249 Số 5 - Trang F713-F722 - 1985
Fuad N. Ziyadeh, Ellie Kelepouris, Mortimer M. Civan, Zalman S. Agus
This study examined the possible existence and nature of Ca2+ transport in frog skin using 45Ca fluxes and short-circuiting technique. Following the addition to full-thickness frog skin (FTFS) of 8-[p-chlorophenylthio]cAMP (8-CPT-cAMP), forskolin, or 1-methyl-3-isobutylxanthine, the secretory Ca2+ flux increased severalfold, inducing net Ca2+ secretion. The absorptive flux was unchanged. ...... hiện toàn bộ
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