American Journal of Physiology - Renal Physiology
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Selectivity of cyclooxygenase isoform activity and prostanoid production in normal and diseased Han:SPRD-cyrat kidneysRenal prostanoids are important regulators of normal renal function and maintenance of renal homeostasis. In diseased kidneys, renal cylooxygenase (COX) expression and prostanoid formation are altered. With the use of the Han:Sprague-Dawley- cy rat, the aim of this study was to determine the relative contribution of renal COX isoforms (protein, gene expression, and activity) on renal prost... ... hiện toàn bộ
American Journal of Physiology - Renal Physiology - Tập 290 Số 4 - Trang F897-F904 - 2006
Selective COX-2 inhibition markedly slows disease progression and attenuates altered prostanoid production in Han:SPRD-cyrats with inherited kidney diseaseSelective cyclooxygenase-2 (COX-2) inhibitors appear to have beneficial renoprotective effects in most, but not all, renal disease conditions. The objective of our study was to examine the effects of COX-2 inhibition in a rat model of polycystic kidney disease. Four-week-old Han:SPRD- cy rats were given a standard rodent diet containing NS-398 (3 mg·kg body wt−1 ·day... hiện toàn bộ
American Journal of Physiology - Renal Physiology - Tập 293 Số 3 - Trang F821-F830 - 2007
Gene expression of 5-, 12-, and 15-lipoxygenases and leukotriene receptors along the rat nephronThe arachidonate signaling pathways comprise prostanoids formed by cyclooxygenases, EETs, and HETEs formed by cytochrome P-450 (CYP) enzymes and HETEs and leukotrienes generated by lipoxygenases. Whereas the intrarenal localization of cyclooxygenases and of some CYP enzymes along the nephron has already been determined, the localization of lipoxygenases and leukotriene-forming enzymes toge... ... hiện toàn bộ
American Journal of Physiology - Renal Physiology - Tập 290 Số 4 - Trang F864-F872 - 2006
Bone buffering of acid and base in humansThe sources and rates of metabolic acid production in relation to renal net acid excretion and thus acid balance in humans have remained controversial. The techniques and possible errors in these measurements are reviewed, as is the relationship of charge balance to acid balance. The results demonstrate that when acid production is experimentally increased among healthy subjects, renal net... ... hiện toàn bộ
American Journal of Physiology - Renal Physiology - Tập 285 Số 5 - Trang F811-F832 - 2003
Suppression of HGF receptor gene expression by oxidative stress is mediated through the interplay between Sp1 and Egr-1Hepatocyte growth factor (HGF) receptor, the product of the c-metprotooncogene, is transcriptionally regulated by a wide variety of cytokines as well as extracellular environmental cues. In this report, we demonstrate that c-met expression was significantly suppressed by oxidative stress. Treatment of mouse renal inner medullary collecting duct epithelial cells with 0.5 mM H2... hiện toàn bộ
American Journal of Physiology - Renal Physiology - Tập 284 Số 6 - Trang F1216-F1225 - 2003
Albumin overload induces adaptive responses in human proximal tubular cells through oxidative stress but not via angiotensin II type 1 receptorProteinuria is pathogenic to proximal tubular cells (PTC) and linked with progression to renal failure. The aim of this study was to determine the effects of human serum albumin (HSA) overload on the changes in gene and protein expression stimulated by oxidative stress in PTC and any interaction with ANG II that is pivotal in disease pathogenesis. Markers of oxidative stress, antioxidant d... ... hiện toàn bộ
American Journal of Physiology - Renal Physiology - Tập 292 Số 6 - Trang F1846-F1857 - 2007
The Na+-Picotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary PiThe principal mediators of renal phosphate (Pi ) reabsorption are the SLC34 family proteins NaPi-IIa and NaPi-IIc, localized to the proximal tubule (PT) apical membrane. Their abundance is regulated by circulatory factors and dietary Pi . Although their physiological importance has been confirmed in knockout animal studies, significant Pi... hiện toàn bộ
American Journal of Physiology - Renal Physiology - Tập 296 Số 4 - Trang F691-F699 - 2009
A current understanding of vascular calcification in CKDPatients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have significant cardiovascular morbidity and mortality that is in part due to the development of vascular calcification. Vascular calcification is an active, highly regulated process that shares many similarities with normal bone formation. New discoveries related to extracellular vesicles, microRNAs, and calcip... ... hiện toàn bộ
American Journal of Physiology - Renal Physiology - Tập 307 Số 8 - Trang F891-F900 - 2014
Glomerular endothelial cell fenestrations: an integral component of the glomerular filtration barrierGlomerular endothelial cell (GEnC) fenestrations are analogous to podocyte filtration slits, but their important contribution to the glomerular filtration barrier has not received corresponding attention. GEnC fenestrations are transcytoplasmic holes, specialized for their unique role as a prerequisite for filtration across the glomerular capillary wall. Glomerular filtration rate is depen... ... hiện toàn bộ
American Journal of Physiology - Renal Physiology - Tập 296 Số 5 - Trang F947-F956 - 2009
Critical roles of Sp1 in gene expression of human and rat H+/organic cation antiporter MATE1 A H+ /organic cation antiporter (multidrug and toxin extrusion 1: MATE1/SLC47A1) plays important roles in the tubular secretion of various clinically important cationic drugs such as cimetidine. We have recently found that the regulation of this transporter greatly affects the pharmacokinetic properties of cationic drugs in vivo. No information is available about the r... ... hiện toàn bộ
American Journal of Physiology - Renal Physiology - Tập 293 Số 5 - Trang F1564-F1570 - 2007
Tổng số: 190
- 1
- 2
- 3
- 4
- 5
- 6
- 10