American Journal of Physiology - Renal Physiology

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Selectivity of cyclooxygenase isoform activity and prostanoid production in normal and diseased Han:SPRD-cyrat kidneys
American Journal of Physiology - Renal Physiology - Tập 290 Số 4 - Trang F897-F904 - 2006
Lori Warford‐Woolgar, Claudia Yu-Chen Peng, Jamie N. Shuhyta, Andrew Wakefield, Deepa Sankaran, Malcolm R. Ogborn, Harold M. Aukema
Renal prostanoids are important regulators of normal renal function and maintenance of renal homeostasis. In diseased kidneys, renal cylooxygenase (COX) expression and prostanoid formation are altered. With the use of the Han:Sprague-Dawley- cy rat, the aim of this study was to determine the relative contribution of renal COX isoforms (protein, gene expression, and activity) on renal prostanoid pr... hiện toàn bộ
Selective COX-2 inhibition markedly slows disease progression and attenuates altered prostanoid production in Han:SPRD-cyrats with inherited kidney disease
American Journal of Physiology - Renal Physiology - Tập 293 Số 3 - Trang F821-F830 - 2007
Deepa Sankaran, Neda Bankovic‐Calic, Malcolm R. Ogborn, G. H. Crow, Harold M. Aukema
Selective cyclooxygenase-2 (COX-2) inhibitors appear to have beneficial renoprotective effects in most, but not all, renal disease conditions. The objective of our study was to examine the effects of COX-2 inhibition in a rat model of polycystic kidney disease. Four-week-old Han:SPRD- cy rats were given a standard rodent diet containing NS-398 (3 mg·kg body wt−1·day−1) or a control diet without NS... hiện toàn bộ
Gene expression of 5-, 12-, and 15-lipoxygenases and leukotriene receptors along the rat nephron
American Journal of Physiology - Renal Physiology - Tập 290 Số 4 - Trang F864-F872 - 2006
Stephan W Reinhold, Helga Vitzthum, Thomas Filbeck, Konrad Wolf, Christos Lattas, Günter A.J. Riegger, Armin Kurtz, Bernhard K. Krämer
The arachidonate signaling pathways comprise prostanoids formed by cyclooxygenases, EETs, and HETEs formed by cytochrome P-450 (CYP) enzymes and HETEs and leukotrienes generated by lipoxygenases. Whereas the intrarenal localization of cyclooxygenases and of some CYP enzymes along the nephron has already been determined, the localization of lipoxygenases and leukotriene-forming enzymes together wit... hiện toàn bộ
Bone buffering of acid and base in humans
American Journal of Physiology - Renal Physiology - Tập 285 Số 5 - Trang F811-F832 - 2003
Jacob Lemann, David A. Bushinsky, L. Lee Hamm
The sources and rates of metabolic acid production in relation to renal net acid excretion and thus acid balance in humans have remained controversial. The techniques and possible errors in these measurements are reviewed, as is the relationship of charge balance to acid balance. The results demonstrate that when acid production is experimentally increased among healthy subjects, renal net acid ex... hiện toàn bộ
Suppression of HGF receptor gene expression by oxidative stress is mediated through the interplay between Sp1 and Egr-1
American Journal of Physiology - Renal Physiology - Tập 284 Số 6 - Trang F1216-F1225 - 2003
Xianghong Zhang, Youhua Liu
Hepatocyte growth factor (HGF) receptor, the product of the c-metprotooncogene, is transcriptionally regulated by a wide variety of cytokines as well as extracellular environmental cues. In this report, we demonstrate that c-met expression was significantly suppressed by oxidative stress. Treatment of mouse renal inner medullary collecting duct epithelial cells with 0.5 mM H2O2inhibited c-met mRNA... hiện toàn bộ
Albumin overload induces adaptive responses in human proximal tubular cells through oxidative stress but not via angiotensin II type 1 receptor
American Journal of Physiology - Renal Physiology - Tập 292 Số 6 - Trang F1846-F1857 - 2007
Liliana Shalamanova, Frank McArdle, Alieu Amara, Malcolm J. Jackson, Rana Rustom
Proteinuria is pathogenic to proximal tubular cells (PTC) and linked with progression to renal failure. The aim of this study was to determine the effects of human serum albumin (HSA) overload on the changes in gene and protein expression stimulated by oxidative stress in PTC and any interaction with ANG II that is pivotal in disease pathogenesis. Markers of oxidative stress, antioxidant defences,... hiện toàn bộ
The Na+-Picotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi
American Journal of Physiology - Renal Physiology - Tập 296 Số 4 - Trang F691-F699 - 2009
Ricardo Villa‐Bellosta, Silvia Ravera, Vı́ctor Sorribas, Gerti Stange, Moshe Levi, Heini Murer, Jürg Biber, Ian C. Forster
The principal mediators of renal phosphate (Pi) reabsorption are the SLC34 family proteins NaPi-IIa and NaPi-IIc, localized to the proximal tubule (PT) apical membrane. Their abundance is regulated by circulatory factors and dietary Pi. Although their physiological importance has been confirmed in knockout animal studies, significant Pireabsorptive capacity remains, which suggests the involvement ... hiện toàn bộ
A current understanding of vascular calcification in CKD
American Journal of Physiology - Renal Physiology - Tập 307 Số 8 - Trang F891-F900 - 2014
Neil J. Paloian, Cecilia M. Giachelli
Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have significant cardiovascular morbidity and mortality that is in part due to the development of vascular calcification. Vascular calcification is an active, highly regulated process that shares many similarities with normal bone formation. New discoveries related to extracellular vesicles, microRNAs, and calciprotein p... hiện toàn bộ
Glomerular endothelial cell fenestrations: an integral component of the glomerular filtration barrier
American Journal of Physiology - Renal Physiology - Tập 296 Số 5 - Trang F947-F956 - 2009
Simon C. Satchell, Filip Braet
Glomerular endothelial cell (GEnC) fenestrations are analogous to podocyte filtration slits, but their important contribution to the glomerular filtration barrier has not received corresponding attention. GEnC fenestrations are transcytoplasmic holes, specialized for their unique role as a prerequisite for filtration across the glomerular capillary wall. Glomerular filtration rate is dependent on ... hiện toàn bộ
Critical roles of Sp1 in gene expression of human and rat H+/organic cation antiporter MATE1
American Journal of Physiology - Renal Physiology - Tập 293 Số 5 - Trang F1564-F1570 - 2007
Moto Kajiwara, Tomohiro Terada, Junichi Asaka, K. OGASAWARA, Toshiya Katsura, Osamu Ogawa, Atsushi Fukatsu, Toshio Doi, Ken‐ichi Inui
A H+/organic cation antiporter (multidrug and toxin extrusion 1: MATE1/SLC47A1) plays important roles in the tubular secretion of various clinically important cationic drugs such as cimetidine. We have recently found that the regulation of this transporter greatly affects the pharmacokinetic properties of cationic drugs in vivo. No information is available about the regulatory mechanisms for the M... hiện toàn bộ
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