American Journal of Physiology - Heart and Circulatory Physiology

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Regulatory role of ovarian sex hormones in calcium uptake activity of cardiac sarcoplasmic reticulum
American Journal of Physiology - Heart and Circulatory Physiology - Tập 291 Số 3 - Trang H1101-H1108 - 2006
Tepmanas Bupha‐Intr, Jonggonnee Wattanapermpool
Alterations in the intracellular Ca2+handling in cardiomyocytes may underlie the cardiac dysfunction observed in the ovarian sex hormone-deprived condition. To test the hypothesis that ovarian sex hormones had a significant role in the cardiac intracellular Ca2+mobilization, the sarcoplasmic reticulum (SR) Ca2+uptake and SR Ca<...... hiện toàn bộ
Correlation between heart valve interstitial cell stiffness and transvalvular pressure: implications for collagen biosynthesis
American Journal of Physiology - Heart and Circulatory Physiology - Tập 290 Số 1 - Trang H224-H231 - 2006
W. David Merryman, Inchan Youn, Howard Lukoff, Paula M. Krueger, Farshid Guilak, Richard A. Hopkins, Michael S. Sacks
It has been speculated that heart valve interstitial cells (VICs) maintain valvular tissue homeostasis through regulated extracellular matrix (primarily collagen) biosynthesis. VICs appear to be phenotypically plastic, inasmuch as they transdifferentiate into myofibroblasts during valve development, disease, and remodeling. Under normal physiological conditions, transvalvular pressures (T...... hiện toàn bộ
cADP-ribose activates reconstituted ryanodine receptors from coronary arterial smooth muscle
American Journal of Physiology - Heart and Circulatory Physiology - Tập 280 Số 1 - Trang H208-H215 - 2001
Pin-Lan Li, Wang-Xian Tang, Héctor H. Valdivia, Ai-Ping Zou, William B. Campbell
The present study was designed to test the hypothesis that cADP-ribose (cADPR) increases Ca2+release through activation of ryanodine receptors (RYR) on the sarcoplasmic reticulum (SR) in coronary arterial smooth muscle cells (CASMCs). We reconstituted RYR from the SR of CASMCs into planar lipid bilayers and examined the effect of cADPR on the activity of these Ca... hiện toàn bộ
Different roles of ryanodine receptors and inositol (1,4,5)-trisphosphate receptors in adrenergically stimulated contractions of small arteries
American Journal of Physiology - Heart and Circulatory Physiology - Tập 287 Số 2 - Trang H617-H625 - 2004
Christine Lamont, W. Gil Wier
Frequency-dependent and proarrhythmogenic effects of FK-506 in rat ventricular cells
American Journal of Physiology - Heart and Circulatory Physiology - Tập 288 Số 2 - Trang H778-H786 - 2005
Jérémy Fauconnier, Alain Lacampagne, Jean-Michel Rauzier, Pierre Fontanaud, Jean-Marc Frapier, Ole M. Sejersted, Guy Vassort, Sylvain Richard
FK-506, a widely used immunosuppressant, has caused a few clinical cases with QT prolongation and torsades de pointe at high blood concentration. The proarrhytmogenic potential of FK-506 was investigated in single rat ventricular cells using the whole cell clamp method to record action potentials (APs) and ionic currents. Fluorescence measurements of Ca2+ transients w...... hiện toàn bộ
A positive inotropic effect of ATP in the human cardiac atrium
American Journal of Physiology - Heart and Circulatory Physiology - Tập 294 Số 4 - Trang H1716-H1723 - 2008
Ulrich Gergs, Peter Boknı́k, Wilhelm Schmitz, Andreas Simm, RE Silber, Joachim Neumann
We studied contractile effects in isolated electrically driven (1 Hz) atrial preparations from patients undergoing cardiac bypass surgery. ATP concentration dependently (10, 30, and 100 μM) and rapidly decreased force of contraction (negative inotropic effect, NIE) and thereafter more slowly increased force of contraction. The maximum positive inotropic effect (PIE) at 100 μM ATP amounted...... hiện toàn bộ
α1-AR-induced positive inotropic response in heart is dependent on myosin light chain phosphorylation
American Journal of Physiology - Heart and Circulatory Physiology - Tập 283 Số 4 - Trang H1471-H1480 - 2002
Geir Øystein Andersen, Eirik Qvigstad, Iwona Schiander, Halfdan Aass, Jan-Bjørn Osnes, Tor Skomedal
The possible involvement of different kinases in the α1-adrenoreceptor (AR)-mediated positive inotropic effect (PIE) was investigated in rat papillary muscle and compared with β-AR-, endothelin receptor- and phorbol ester-induced changes in contractility. The α1-AR-induced PIE was not reduced by the inhibitors of protein kinase C (PKC), MAPK (ERK a...... hiện toàn bộ
A novel phospholipase C- and cAMP-independent positive inotropic mechanism via a P2 purinoceptor
American Journal of Physiology - Heart and Circulatory Physiology - Tập 273 Số 5 - Trang H2380-H2387 - 1997
Ernest Podrasky, David Xu, Bruce T. Liang
Although ATP, acting through a P2 purinoceptor, can stimulate a pronounced positive inotropic effect in cardiac ventricular myocytes, the receptor-effector mechanism that underlies this stimulatory cardiac action is not well understood. The objectives of the present study were to develop the cultured chick embryo ventricular myocytes as a novel model for the cardiac P2 purinoceptor and to ...... hiện toàn bộ
Determinants of action potential initiation in isolated rabbit atrial and ventricular myocytes
American Journal of Physiology - Heart and Circulatory Physiology - Tập 274 Số 6 - Trang H1902-H1913 - 1998
David A. Golod, Rajiv Kumar, Ronald W. Joyner
Action potential conduction through the atrium and the ventricle of the heart depends on the membrane properties of the atrial and ventricular cells, particularly with respect to the determinants of the initiation of action potentials in each cell type. We have utilized both current- and voltage-clamp techniques on isolated cells to examine biophysical properties of the two cell types at ...... hiện toàn bộ
The ubiquitin proteasome system and myocardial ischemia
American Journal of Physiology - Heart and Circulatory Physiology - Tập 304 Số 3 - Trang H337-H349 - 2013
Justine Calise, Saul R. Powell
The ubiquitin proteasome system (UPS) has been the subject of intensive research over the past 20 years to define its role in normal physiology and in pathophysiology. Many of these studies have focused in on the cardiovascular system and have determined that the UPS becomes dysfunctional in several pathologies such as familial and idiopathic cardiomyopathies, atherosclerosis, and myocardi...... hiện toàn bộ
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