American Journal of Physiology - Heart and Circulatory Physiology

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Regulatory role of ovarian sex hormones in calcium uptake activity of cardiac sarcoplasmic reticulum
American Journal of Physiology - Heart and Circulatory Physiology - Tập 291 Số 3 - Trang H1101-H1108 - 2006
Tepmanas Bupha‐Intr, Jonggonnee Wattanapermpool
Alterations in the intracellular Ca2+handling in cardiomyocytes may underlie the cardiac dysfunction observed in the ovarian sex hormone-deprived condition. To test the hypothesis that ovarian sex hormones had a significant role in the cardiac intracellular Ca2+mobilization, the sarcoplasmic reticulum (SR) Ca2+uptake and SR Ca<...... hiện toàn bộ
Dual functional roles of Tie-2/angiopoietin in TNF-α-mediated angiogenesis
American Journal of Physiology - Heart and Circulatory Physiology - Tập 287 Số 1 - Trang H187-H195 - 2004
Jian‐Xiong Chen, Ying Chen, Laura M. DeBusk, Wen‐Yu Lin, Pengnain Charles Lin
Inflammation and angiogenesis are associated with pathological disorders. TNF-α is a major inflammatory cytokine that also regulates angiogenesis. TNF-α has been shown to regulate Tie-2 and angiopoietin (Ang) expression, but the functional significance is less clear. In this study, we showed that TNF-α induced a weak angiogenic response in a mouse cornea assay. Systemic overexpression of A...... hiện toàn bộ
Inducible PDGF A-chain transcription in smooth muscle cells is mediated by Egr-1 displacement of Sp1 and Sp3
American Journal of Physiology - Heart and Circulatory Physiology - Tập 273 Số 3 - Trang H1415-H1426 - 1997
Eric S. Silverman, Levon M. Khachigian, Volkhard Lindner, Amy J. Williams, Teresa Collins
Platelet-derived growth factor (PDGF) A-chain is expressed by vascular smooth muscle cells (SMC) in a variety of pathological settings. Phorbol 12-myristate 13-acetate (PMA) increases A-chain transcription and was used as a model agonist. Transient transfection analysis identified a region in the promoter that is required for inducibility, located between base pairs -71 and -55 from the t...... hiện toàn bộ
High-sodium intake prevents pregnancy-induced decrease of blood pressure in the rat
American Journal of Physiology - Heart and Circulatory Physiology - Tập 285 Số 1 - Trang H375-H383 - 2003
Annie Beauséjour, Karine Auger, Jean St‐Louis, Martin Brochu
Despite an increase of circulatory volume and of renin-angiotensin-aldosterone system (RAAS) activity, pregnancy is paradoxically accompanied by a decrease in blood pressure. We have reported that the decrease in blood pressure was maintained in pregnant rats despite overactivation of RAAS following reduction in sodium intake. The purpose of this study was to evaluate the impact of the opp...... hiện toàn bộ
Correlation between heart valve interstitial cell stiffness and transvalvular pressure: implications for collagen biosynthesis
American Journal of Physiology - Heart and Circulatory Physiology - Tập 290 Số 1 - Trang H224-H231 - 2006
W. David Merryman, Inchan Youn, Howard Lukoff, Paula M. Krueger, Farshid Guilak, Richard A. Hopkins, Michael S. Sacks
It has been speculated that heart valve interstitial cells (VICs) maintain valvular tissue homeostasis through regulated extracellular matrix (primarily collagen) biosynthesis. VICs appear to be phenotypically plastic, inasmuch as they transdifferentiate into myofibroblasts during valve development, disease, and remodeling. Under normal physiological conditions, transvalvular pressures (T...... hiện toàn bộ
Reactive oxygen species from smooth muscle mitochondria initiate cold-induced constriction of cutaneous arteries
American Journal of Physiology - Heart and Circulatory Physiology - Tập 289 Số 1 - Trang H243-H250 - 2005
Simon Bailey, Sayan Mitra, Sheila Flavahan, Nicholas A. Flavahan
Cold constricts cutaneous blood vessels by selectively increasing the activity of smooth muscle α2-adrenoceptors (α2-ARs). In mouse tail arteries, α2-AR constriction is mediated by α2A-ARs at 37°C, whereas the cold-induced augmentation in α2-AR activity is mediated entirely by α... hiện toàn bộ
cADP-ribose activates reconstituted ryanodine receptors from coronary arterial smooth muscle
American Journal of Physiology - Heart and Circulatory Physiology - Tập 280 Số 1 - Trang H208-H215 - 2001
Pin-Lan Li, Wang-Xian Tang, Héctor H. Valdivia, Ai-Ping Zou, William B. Campbell
The present study was designed to test the hypothesis that cADP-ribose (cADPR) increases Ca2+release through activation of ryanodine receptors (RYR) on the sarcoplasmic reticulum (SR) in coronary arterial smooth muscle cells (CASMCs). We reconstituted RYR from the SR of CASMCs into planar lipid bilayers and examined the effect of cADPR on the activity of these Ca... hiện toàn bộ
Cyclic ADP ribose-mediated Ca2+signaling in mediating endothelial nitric oxide production in bovine coronary arteries
American Journal of Physiology - Heart and Circulatory Physiology - Tập 290 Số 3 - Trang H1172-H1181 - 2006
Guo Zhang, Eric G. Teggatz, Andrew Y. Zhang, Matthew J. Koeberl, Fan Yi, Li Chen, Pin‐Lan Li
The present study tested the hypothesis that cyclic ADP ribose (cADPR) serves as a novel second messenger to mediate intracellular Ca2+mobilization in coronary arterial endothelial cells (CAECs) and thereby contributes to endothelium-dependent vasodilation. In isolated and perfused small bovine coronary arteries, bradykinin (BK)-induced concentration-dependent vasodila...... hiện toàn bộ
Different roles of ryanodine receptors and inositol (1,4,5)-trisphosphate receptors in adrenergically stimulated contractions of small arteries
American Journal of Physiology - Heart and Circulatory Physiology - Tập 287 Số 2 - Trang H617-H625 - 2004
Christine Lamont, W. Gil Wier
Ouabain augments Ca2+ transients in arterial smooth muscle without raising cytosolic Na+
American Journal of Physiology - Heart and Circulatory Physiology - Tập 279 Số 2 - Trang H679-H691 - 2000
Assaf Arnon, John M. Hamlyn, Mordecai P. Blaustein
Ouabain and other cardiotonic steroids (CTS) inhibit Na+ pumps and are widely believed to exert their cardiovascular effects by raising the cytosolic Na+ concentration ([Na+]cyt) and Ca2+. This view has not been rigorously reexamined despite evidence that low-dose CTS may act without e...... hiện toàn bộ
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