American Journal of Physiology - Heart and Circulatory Physiology

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Regulatory role of ovarian sex hormones in calcium uptake activity of cardiac sarcoplasmic reticulum
American Journal of Physiology - Heart and Circulatory Physiology - Tập 291 Số 3 - Trang H1101-H1108 - 2006
Tepmanas Bupha‐Intr, Jonggonnee Wattanapermpool
Alterations in the intracellular Ca2+handling in cardiomyocytes may underlie the cardiac dysfunction observed in the ovarian sex hormone-deprived condition. To test the hypothesis that ovarian sex hormones had a significant role in the cardiac intracellular Ca2+mobilization, the sarcoplasmic reticulum (SR) Ca2+uptake and SR Ca<...... hiện toàn bộ
Dual functional roles of Tie-2/angiopoietin in TNF-α-mediated angiogenesis
American Journal of Physiology - Heart and Circulatory Physiology - Tập 287 Số 1 - Trang H187-H195 - 2004
Jian‐Xiong Chen, Ying Chen, Laura M. DeBusk, Wen‐Yu Lin, Pengnain Charles Lin
Inflammation and angiogenesis are associated with pathological disorders. TNF-α is a major inflammatory cytokine that also regulates angiogenesis. TNF-α has been shown to regulate Tie-2 and angiopoietin (Ang) expression, but the functional significance is less clear. In this study, we showed that TNF-α induced a weak angiogenic response in a mouse cornea assay. Systemic overexpression of A...... hiện toàn bộ
Correlation between heart valve interstitial cell stiffness and transvalvular pressure: implications for collagen biosynthesis
American Journal of Physiology - Heart and Circulatory Physiology - Tập 290 Số 1 - Trang H224-H231 - 2006
W. David Merryman, Inchan Youn, Howard Lukoff, Paula M. Krueger, Farshid Guilak, Richard A. Hopkins, Michael S. Sacks
It has been speculated that heart valve interstitial cells (VICs) maintain valvular tissue homeostasis through regulated extracellular matrix (primarily collagen) biosynthesis. VICs appear to be phenotypically plastic, inasmuch as they transdifferentiate into myofibroblasts during valve development, disease, and remodeling. Under normal physiological conditions, transvalvular pressures (T...... hiện toàn bộ
Reactive oxygen species from smooth muscle mitochondria initiate cold-induced constriction of cutaneous arteries
American Journal of Physiology - Heart and Circulatory Physiology - Tập 289 Số 1 - Trang H243-H250 - 2005
Simon Bailey, Sayan Mitra, Sheila Flavahan, Nicholas A. Flavahan
Cold constricts cutaneous blood vessels by selectively increasing the activity of smooth muscle α2-adrenoceptors (α2-ARs). In mouse tail arteries, α2-AR constriction is mediated by α2A-ARs at 37°C, whereas the cold-induced augmentation in α2-AR activity is mediated entirely by α... hiện toàn bộ
cADP-ribose activates reconstituted ryanodine receptors from coronary arterial smooth muscle
American Journal of Physiology - Heart and Circulatory Physiology - Tập 280 Số 1 - Trang H208-H215 - 2001
Pin-Lan Li, Wang-Xian Tang, Héctor H. Valdivia, Ai-Ping Zou, William B. Campbell
The present study was designed to test the hypothesis that cADP-ribose (cADPR) increases Ca2+release through activation of ryanodine receptors (RYR) on the sarcoplasmic reticulum (SR) in coronary arterial smooth muscle cells (CASMCs). We reconstituted RYR from the SR of CASMCs into planar lipid bilayers and examined the effect of cADPR on the activity of these Ca... hiện toàn bộ
Different roles of ryanodine receptors and inositol (1,4,5)-trisphosphate receptors in adrenergically stimulated contractions of small arteries
American Journal of Physiology - Heart and Circulatory Physiology - Tập 287 Số 2 - Trang H617-H625 - 2004
Christine Lamont, W. Gil Wier
Frequency-dependent and proarrhythmogenic effects of FK-506 in rat ventricular cells
American Journal of Physiology - Heart and Circulatory Physiology - Tập 288 Số 2 - Trang H778-H786 - 2005
Jérémy Fauconnier, Alain Lacampagne, Jean-Michel Rauzier, Pierre Fontanaud, Jean-Marc Frapier, Ole M. Sejersted, Guy Vassort, Sylvain Richard
FK-506, a widely used immunosuppressant, has caused a few clinical cases with QT prolongation and torsades de pointe at high blood concentration. The proarrhytmogenic potential of FK-506 was investigated in single rat ventricular cells using the whole cell clamp method to record action potentials (APs) and ionic currents. Fluorescence measurements of Ca2+ transients w...... hiện toàn bộ
Nitric oxide inhibits Ca2+mobilization through cADP-ribose signaling in coronary arterial smooth muscle cells
American Journal of Physiology - Heart and Circulatory Physiology - Tập 279 Số 3 - Trang H873-H881 - 2000
Jiang-Zhou Yu, David X. Zhang, Ai-Ping Zou, William B. Campbell, Pin‐Lan Li
The present study was designed to determine whether the cADP-ribose-mediated Ca2+signaling is involved in the inhibitory effect of nitric oxide (NO) on intracellular Ca2+mobilization. With the use of fluorescent microscopic spectrometry, cADP-ribose-induced Ca2+release from sarcoplasmic reticulum (SR) of bovine coronary arteria...... hiện toàn bộ
A positive inotropic effect of ATP in the human cardiac atrium
American Journal of Physiology - Heart and Circulatory Physiology - Tập 294 Số 4 - Trang H1716-H1723 - 2008
Ulrich Gergs, Peter Boknı́k, Wilhelm Schmitz, Andreas Simm, RE Silber, Joachim Neumann
We studied contractile effects in isolated electrically driven (1 Hz) atrial preparations from patients undergoing cardiac bypass surgery. ATP concentration dependently (10, 30, and 100 μM) and rapidly decreased force of contraction (negative inotropic effect, NIE) and thereafter more slowly increased force of contraction. The maximum positive inotropic effect (PIE) at 100 μM ATP amounted...... hiện toàn bộ
α1-AR-induced positive inotropic response in heart is dependent on myosin light chain phosphorylation
American Journal of Physiology - Heart and Circulatory Physiology - Tập 283 Số 4 - Trang H1471-H1480 - 2002
Geir Øystein Andersen, Eirik Qvigstad, Iwona Schiander, Halfdan Aass, Jan-Bjørn Osnes, Tor Skomedal
The possible involvement of different kinases in the α1-adrenoreceptor (AR)-mediated positive inotropic effect (PIE) was investigated in rat papillary muscle and compared with β-AR-, endothelin receptor- and phorbol ester-induced changes in contractility. The α1-AR-induced PIE was not reduced by the inhibitors of protein kinase C (PKC), MAPK (ERK a...... hiện toàn bộ
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