American Journal of Clinical Dermatology
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Persistent Generalized Lichen Nitidus Successfully Treated with Enoxaparin Sodium
American Journal of Clinical Dermatology - Tập 9 - Trang 349-350 - 2012
Toxic Side Effects of Targeted Therapies and Immunotherapies Affecting the Skin, Oral Mucosa, Hair, and Nails
American Journal of Clinical Dermatology - Tập 19 - Trang 31-39 - 2018
Targeted therapies and immunotherapies are associated with a wide range of dermatologic adverse events (dAEs) resulting from common signaling pathways involved in malignant behavior and normal homeostatic functions of the epidermis and dermis. Dermatologic toxicities include damage to the skin, oral mucosa, hair, and nails. Acneiform rash is the most common dAE, observed in 25–85% of patients trea......
Efalizumab
American Journal of Clinical Dermatology - Tập 10 - Trang 51-72 - 2012
Efalizumab (Raptiva®) is a recombinant, humanized, monoclonal antibody that targets CD11a, the a-subunit of the heterodimeric lymphocyte surface protein lymphocyte function-associated antigen-1 (LFA-1). It is approved for the treatment of adult patients (aged ≥ 18 years) with chronic moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy (in the US), or who hav......
Important Controversies Associated with Isotretinoin Therapy for Acne
American Journal of Clinical Dermatology - Tập 14 - Trang 71-76 - 2013
Isotretinoin is a remarkably effective drug for severe, recalcitrant acne vulgaris. Soon after the drug’s release in the early 1980s, a number of important adverse effects were reported subsequently leading to a variety of medical and medicolegal controversies. Three of these controversies will be highlighted concerning the putative role of isotretinoin in (1) depression and suicide, (2) inflammat......
Combination Therapy with Apremilast and Biologics for Psoriasis: A Systematic Review
American Journal of Clinical Dermatology - Tập 23 - Trang 605-613 - 2022
The evidence for adding small-molecule drugs to an ongoing biologic treatment is sparse, but combination therapies appear to be advantageous in appropriately selected patients with psoriasis. To our knowledge, efficacy and safety of combination therapy with apremilast and biologics has not previously been reviewed. A literature search was performed on Medline (PubMed), Embase, Web of Science, and ......
A Comprehensive Review of the Long-Term and Short-Term Treatment of Melasma with a Triple Combination Cream
American Journal of Clinical Dermatology - Tập 7 - Trang 223-230 - 2012
Melasma is a common disorder of hyperpigmentation and generally involves areas of the face and neck. Hyperpigmentation is especially prevalent in darker complected patients and is often difficult to treat. Hydroquinone, tretinoin, and topical corticosteroids are well established monotherapeutic agents for treating melasma and hyperpigmentation; however, a stable, once-daily formulation triple comb......
Correction to: Efficacy and Safety of Switching to Ixekizumab in Etanercept Non-Responders: A Subanalysis from Two Phase III Randomized Clinical Trials in Moderate-to-Severe Plaque Psoriasis (UNCOVER-2 and -3)
American Journal of Clinical Dermatology - Tập 19 - Trang 457-457 - 2018
The article Efficacy and Safety of Switching to Ixekizumab in Etanercept Non-Responders: A Subanalysis from Two Phase III Randomized Clinical Trials in Moderate-to-Severe Plaque Psoriasis (UNCOVER-2 and -3) written by Andrew Blauvelt
Multikinase Inhibitor-Induced Hand–Foot Skin Reaction: A Review of Clinical Presentation, Pathogenesis, and Management
American Journal of Clinical Dermatology - Tập 17 - Trang 387-402 - 2016
Multikinase inhibitors (MKIs) are targeted cancer therapies designed to inhibit multiple tyrosine kinase pathways responsible for tumor proliferation, growth, and survival. These agents are more able to target cancer cells and possess better safety profiles than conventional chemotherapies. However, MKIs can produce significant cutaneous adverse events, hand–foot skin reaction (HFSR) being the mos......
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