American Journal of Cardiovascular Drugs
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The Current Place of DPP4 Inhibitors in the Evolving Landscape of Type 2 Diabetes Management: Is It Time to Bid Adieu?
American Journal of Cardiovascular Drugs - Tập 23 - Trang 601-608 - 2023
During the last decade, the landscape of type 2 diabetes (T2D) management has been completely transformed, moving from a glucose-centric perspective to a holistic approach that also takes into account weight control and organ protection. Dipeptidyl peptidase-4 inhibitors (DPP4i) are oral agents that have been used for the treatment of T2D for almost 20 years. Although they present an excellent saf......
Clinical Practice Guidelines for Hypertension: Evaluation of Quality Using the AGREE II Instrument
American Journal of Cardiovascular Drugs - Tập 16 - Trang 439-451 - 2016
Hypertension is an important public health challenge. The purpose of clinical practice guidelines (CPGs) is to provide explicit recommendations for clinical practice, reduce inadequate variations, optimize results, minimize risks, and promote cost-effective practice. Therefore, a highly methodological quality development process for CPGs is more likely to yield a CPG that contains relevant and app......
Adjuvant Antiarrhythmic Therapy in Patients with Implantable Cardioverter Defibrillators
American Journal of Cardiovascular Drugs - Tập 14 - Trang 89-100 - 2013
The risk of sudden cardiac death from ventricular fibrillation or ventricular tachycardia in patients with cardiomyopathy related to structural heart disease has been favorably impacted by the wide adaptation of implantable cardioverter defibrillators (ICDs) for both primary and secondary prevention. Unfortunately, after ICD implantation both appropriate and inappropriate ICD therapies are common.......
Unraveling the Pivotal Role of Bradykinin in ACE Inhibitor Activity
American Journal of Cardiovascular Drugs - Tập 16 - Trang 309-321 - 2016
Historically, the first described effect of an angiotensin converting enzyme (ACE) inhibitor was an increased activity of bradykinin, one of the substrates of ACE. However, in the subsequent years, molecular models describing the mechanism of action of ACE inhibitors in decreasing blood pressure and cardiovascular risk have focused mostly on the renin-angiotensin system. Nonetheless, over the last......
The Cost Effectiveness of Statin Therapies in Spain in 2010, after the Introduction of Generics and Reference Prices
American Journal of Cardiovascular Drugs - Tập 10 - Trang 369-382 - 2012
HMG-CoA reductase inhibitors (statins) are the first-line drugs for use in the reduction of low-density lipoprotein cholesterol (LDL-C) levels and prevention of coronary heart disease (CHD) in patients with hypercholesterolemia. Generic statins could change the cost effectiveness of statin therapies in Spain, and more population groups could be included in the recommendations for reduction of chol......
Hemodynamic Effects of Sacubitril/Valsartan in Patients with Reduced Left Ventricular Ejection Fraction Over 24 Months: A Retrospective Study
American Journal of Cardiovascular Drugs - Tập 22 - Trang 535-544 - 2022
The effects of sacubitril/valsartan in patients with chronic heart failure with reduced ejection fraction (HFrEF) were recently reported. However, the hemodynamic impact of this well-established treatment in patients with HFrEF has been poorly systematically researched. We aimed to investigate the hemodynamic effects of sacubitril/valsartan among patients with HFrEF. Between 2016 and 2020, we retr......
The Effects of HMG-CoA Reductase Inhibitors on Endothelial Function
American Journal of Cardiovascular Drugs - Tập 6 - Trang 115-120 - 2012
Vascular endothelial dysfunction is a complex phenomenon that is caused by an imbalance of vasodilator and vasoconstrictor factors that regulate the equilibrium-maintaining vascular tone. In the early phase of hypercholesterolemia, endothelial dysfunction precedes vascular wall lesions. One of the earliest recognizable benefits of treatment with HMG-CoA reductase inhibitors (statins) is the normal......
Correlation Between C677T MTHFR Gene Polymorphism, Plasma Homocysteine Levels and the Incidence of CAD
American Journal of Cardiovascular Drugs - Tập 1 - Trang 353-361 - 2012
The lesions of coronary atherosclerosis represent the result of a complex, multicellular, inflammatoryhealing response in the coronary arterial wall. In vivo and in vitro cellular and molecular studies have suggested a role for tissue homocysteine in endothelial cell injury and adverse extra-cellular matrix remodeling. Gene polymorphisms in relation with numerous risk factors might increase the in......
Erratum to: Comparison of the Phase III Clinical Trial Designs of Novel Oral Anticoagulants Versus Warfarin for the Treatment of Nonvalvular Atrial Fibrillation: Implications for Clinical Practice
American Journal of Cardiovascular Drugs - Tập 14 - Trang 237-237 - 2014
Comparing the Cost Effectiveness of Non-vitamin K Antagonist Oral Anticoagulants with Well-Managed Warfarin for Stroke Prevention in Atrial Fibrillation Patients at High Risk of Bleeding
American Journal of Cardiovascular Drugs - Tập 18 - Trang 317-325 - 2018
Several studies have compared the cost effectiveness of non-vitamin K antagonist oral anticoagulants (NOACs) and warfarin using results from clinical trials evaluating NOACs. However, the time in therapeutic range (TTR) of warfarin groups ranged across clinical trials, and all were below the therapeutic goal of 70%. We compared the cost effectiveness of edoxaban 60 mg, apixaban 5 mg, dabigatran 15......
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