American Association for Cancer Research (AACR)

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Suppression of Human Solid Tumor Growth in Mice by Intratumor and Systemic Inoculation of Histidine-Rich and pH-Dependent Host Defense–like Lytic Peptides
American Association for Cancer Research (AACR) - Tập 69 Số 8 - Trang 3458-3463 - 2009
Arik Makovitzki, Avner Fink, Yechiel Shai
Abstract Previously, we reported that intratumor or systemic inoculation of a cationic 15-mer, innate immunity-like lytic peptide composed of d- and l-amino acids ([D]-K6L9) caused growth arrest of 22RV1 prostate carcinoma xenografts in a mouse model. However, despite its therapeutic potential, this peptide has significant systemic toxicity at concentrations slightly higher than the therapeutic on... hiện toàn bộ
A Recurrent Chromosome Breakpoint in Breast Cancer at the NRG1 / Neuregulin 1 / Heregulin Gene
American Association for Cancer Research (AACR) - Tập 64 Số 19 - Trang 6840-6844 - 2004
Huai-En Huang, Suet‐Feung Chin, Christophe Ginestier, Valérie‐Jeanne Bardou, José Adélaı̈de, N. Gopalakrishna Iyer, María J. García, Jessica C. Pole, Grace Callagy, Stephen M. Hewitt, William J. Gullick, Jocelyne Jacquemier, Carlos Caldas, Max Chaffanet, Daniel Birnbaum, Paul A. Edwards
Abstract Most studies of genomic rearrangements in common cancers have focused on regional gains and losses, but some rearrangements may break within specific genes. We previously reported that five breast cancer cell lines have chromosome translocations that break in the NRG1 gene and that could cause abnormal NRG1 expression. NRG1 encodes the Neuregulins 1 (formerly the Heregulins), ligands for ... hiện toàn bộ
Epithelial to Mesenchymal Transition in Human Breast Epithelial Cells Transformed by 17β-Estradiol
American Association for Cancer Research (AACR) - Tập 67 Số 23 - Trang 11147-11157 - 2007
Yong Huang, Sandra V. Fernandez, Shirlean Goodwin, Patrícia A. Russo, Irma H. Russo, Thomas R. Sutter, José Russo
Abstract The estrogen dependence of breast cancer has long been recognized; however, the role of 17β-estradiol (E2) in cancer initiation was not known until we showed that it induces complete neoplastic transformation of the human breast epithelial cells MCF-10F. E2 treatment of MCF-10F cells progressively induced high colony efficiency and loss of ductulogenesis in early transformed (trMCF) cells... hiện toàn bộ
Proapoptotic Kinase MST2 Coordinates Signaling Crosstalk between RASSF1A, Raf-1, and Akt
American Association for Cancer Research (AACR) - Tập 70 Số 3 - Trang 1195-1203 - 2010
David Romano, David Matallanas, Gregory Weitsman, Christian Preisinger, Tony Ng, Walter Kölch
Abstract Mammalian MST kinases function in stress-induced apoptosis to limit tumor progression. However, there is limited understanding about MST2 control by key regulators of cell division and survival. Raf-1 binds and inhibits MST2 kinase, whereas dissociation from Raf-1 and binding to tumor suppressor protein RASSF1A activates MST2. Akt phosphorylates MST2 in response to mitogens, oncogenic Ras... hiện toàn bộ
Role of the Tumor Suppressor RASSF1A in Mst1-Mediated Apoptosis
American Association for Cancer Research (AACR) - Tập 66 Số 5 - Trang 2562-2569 - 2006
Hyun Jung Oh, Kyung-Kwon Lee, Su Jung Song, Mi Sun Jin, Min Sup Song, Joo‐Hyeon Lee, Chang Rak Im, Jie‐Oh Lee, Shin Yonehara, Dae‐Sik Lim
AbstractMammalian sterile 20–like kinase 1 (Mst1) is activated by both caspase-mediated cleavage and phosphorylation in response to apoptotic stimuli, including Fas ligation. Here, we examined the possible role of the tumor suppressor RASSF1A in Mst1 activation and Mst1-mediated apoptosis induced by death receptor signaling. Immunoprecipitation and immunofluorescence analyses revealed that Mst1 wa... hiện toàn bộ
Role of the Polarity Determinant Crumbs in Suppressing Mammalian Epithelial Tumor Progression
American Association for Cancer Research (AACR) - Tập 68 Số 11 - Trang 4105-4115 - 2008
Cristina M. Karp, Ting Ting Tan, Robin Mathew, Deidre Nelson, Chandreyee Mukherjee, Kurt Degenhardt, Vassiliki Karantza‐Wadsworth, Eileen White
Abstract Most tumors are epithelial-derived, and although disruption of polarity and aberrant cellular junction formation is a poor prognosticator in human cancer, the role of polarity determinants in oncogenesis is poorly understood. Using in vivo selection, we identified a mammalian orthologue of the Drosophila polarity regulator crumbs as a gene whose loss of expression promotes tumor progressi... hiện toàn bộ
Phase I Trial of Recombinant Modified Vaccinia Ankara Encoding Epstein–Barr Viral Tumor Antigens in Nasopharyngeal Carcinoma Patients
American Association for Cancer Research (AACR) - Tập 73 Số 6 - Trang 1676-1688 - 2013
Edwin P. Hui, Graham S. Taylor, Hui Jia, Brigette Ma, Stephen L. Chan, Rosalie Ho, Wai-Lap Wong, Steven Ray Wilson, Benjamin F. Johnson, Ceri Edwards, Deborah Stocken, Alan B. Rickinson, Neil Steven, Anthony T.�C. Chan
Abstract Epstein–Barr virus (EBV) is associated with several malignancies including nasopharyngeal carcinoma, a high incidence tumor in Chinese populations, in which tumor cells express the two EBV antigens EB nuclear antigen 1 (EBNA1) and latent membrane protein 2 (LMP2). Here, we report the phase I trial of a recombinant vaccinia virus, MVA-EL, which encodes an EBNA1/LMP2 fusion protein designed... hiện toàn bộ
Promotion of Microsatellite Instability by Hepatitis C Virus Core Protein in Human Non-neoplastic Hepatocyte Cells
American Association for Cancer Research (AACR) - Tập 64 Số 4 - Trang 1307-1314 - 2004
Atsushi Naganuma, Hiromichi Dansako, Takashi Nakamura, Akito Nozaki, Nobuyuki Kato
Abstract Hepatitis C virus proteins exert an effect on a variety of cellular functions, including gene expression, signal transduction, and apoptosis, and because they possess oncogenic potentials, they have also been suggested to play an important role in hepatocarcinogenesis. Although the mechanisms of hepatocarcinogenesis remain poorly understood, we hypothesized that the disease may arise beca... hiện toàn bộ
RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-Mediated Destruction Complex to Suppress Tumorigenesis
American Association for Cancer Research (AACR) - Tập 76 Số 7 - Trang 1847-1859 - 2016
Min-Goo Lee, Seong-In Jeong, Kyung-Phil Ko, Soon Ki Park, Byung-Kyu Ryu, Ick-Young Kim, Jeong-Kook Kim, Sung-Gil Chi
Abstract RASSF1A is a tumor suppressor implicated in many tumorigenic processes; however, the basis for its tumor suppressor functions are not fully understood. Here we show that RASSF1A is a novel antagonist of protumorigenic RhoA activity. Direct interaction between the C-terminal amino acids (256–277) of RASSF1A and active GTP-RhoA was critical for this antagonism. In addition, interaction betw... hiện toàn bộ
Chemotherapy Induces Tumor Clearance Independent of Apoptosis
American Association for Cancer Research (AACR) - Tập 68 Số 23 - Trang 9595-9600 - 2008
Jennifer L. Guerriero, Dara Ditsworth, Yongjun Fan, Fangping Zhao, Howard C. Crawford, Wei‐Xing Zong
Abstract Dysregulation of apoptosis is associated with the development of human cancer and resistance to anticancer therapy. The ultimate goal of cancer treatment is to selectively induce cancer cell death and overcome drug resistance. A deeper understanding of how a given chemotherapy affects tumor cell death is needed to develop strategically designed anticancer agents. Here, we use a xenograft ... hiện toàn bộ
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