Allergy, Asthma & Clinical Immunology
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Delivery of subcutaneous immunoglobulin by rapid “push” infusion for primary immunodeficiency patients in Manitoba: a retrospective review
Allergy, Asthma & Clinical Immunology - Tập 16 - Trang 1-9 - 2020
Both intravenous and subcutaneous human immune globin G (IgG) replacement (IVIG and SCIG, respectively) reduce severe infection and increase serum IgG levels in primary immune deficiency disorder (PIDD) patients who require replacement. SCIG can be administered either with the aid of an infusion pump, or by patients or caregivers themselves, using butterfly needles and a syringe (“SCIG push”). SCI......
Asthma and Therapeutics: Recombinant Therapies in Asthma
Allergy, Asthma & Clinical Immunology - Tập 1 - Trang 1-8 - 2004
Numerous recombinant therapies are being investigated for the treatment of asthma. This report reviews the current status of several of these novel agents. Anti-immunoglobulin (Ig)E (omalizumab, Xolair) markedly inhibits all aspects of the allergen challenge in subjects who have reduction of free serum IgE to undetectable levels. Several clinical studies in atopic asthma have demonstrated benefit ......
Pitfalls of immunotherapy: lessons from a patient with CTLA-4 haploinsufficiency
Allergy, Asthma & Clinical Immunology - Tập 14 - Trang 1-5 - 2018
Daclizumab is a humanized monoclonal antibody that blocks CD25, the high affinity alpha subunit of the interleukin-2 receptor. Daclizumab therapy targets T regulatory cell and activated effector T cell proliferation to suppress autoimmune disease activity, in inflammatory conditions like relapsing and remitting multiple sclerosis. Here, we present the first report of agranulocytosis with daclizuma......
Acuity of asthma exacerbations in Alberta, Canada is increasing: a population-based study
Allergy, Asthma & Clinical Immunology - Tập 20 - Trang 1-5 - 2024
Asthma is a common respiratory illness affecting 2.8 million Canadians, including 9.7% of Albertans. Prior studies showed a substantial decrease in ED visits for asthma in the decade preceding 2010, followed by a stabilization. This was attributed to improvements in the pharmacologic and non-pharmacologic treatments for asthma during that period followed by a balance between epidemiologic drivers ......
Peripheral blood T cells and neutrophils from asthma patients express class-I MHC-restricted T cell-associated molecule
Allergy, Asthma & Clinical Immunology - Tập 10 - Trang 1-6 - 2014
Class-I MHC-restricted T cell-associated molecule (CRTAM) is a protein expressed by activated natural killer T (NKT) cells, natural killer (NK) cells, CD8 T cells, and certain CD4 T lymphocytes. It is also expressed in Purkinje neurons and epithelial cells. However, no studies have examined the expression of CRTAM in peripheral blood cells during homeostasis or disease. Therefore, we explored whet......
The impact of CFTR modulator triple therapy on type 2 inflammatory response in patients with cystic fibrosis
Allergy, Asthma & Clinical Immunology - Tập 19 - Trang 1-9 - 2023
Treatment of cystic fibrosis (CF) has been revolutionized by the use of cystic fibrosis transmembrane conductance regulator (CFTR) protein modulators such as elexacaftor/tezacaftor/ivacaftor (ETI) triple therapy. Prior studies support a role for type 2 (T2) inflammation in many people with CF (PwCF) and CF-asthma overlap syndrome (CFAOS) is considered a separate clinical entity. It is unknown whet......
Primary Prevention of Allergic Diseases: Current Concepts and Mechanisms
Allergy, Asthma & Clinical Immunology - Tập 3 - Trang 1-9 - 2007
Atopic diseases, the new "epidemic of the twenty-first century" and a central health problem of industrial nations, call for the development of innovative primary prevention strategies. The present review provides an overview of current experimental and immunomodulatory procedures and their underlying mechanisms.
Improving detection of work-related asthma: a review of gaps in awareness, reporting and knowledge translationAbstract
Background
Work-related asthma (WRA) accounts for up to 25% of all adults with asthma. Early diagnosis is key for optimal management as delays in diagnosis are associated with worse outcomes. However, WRA is significantly underreported and the median time to diagnosis is 4 years. The objective of this review is to identif... ...
Allergy, Asthma & Clinical Immunology - Tập 16 Số 1 - 2020
Managing paediatric eosinophilic gastroenteropathies: a community experience
Allergy, Asthma & Clinical Immunology - Tập 6 - Trang 1-1 - 2010
First patient in the Iranian Registry with novel DOCK2 gene mutation, presenting with skeletal tuberculosis, and review of literature
Allergy, Asthma & Clinical Immunology - Tập 17 - Trang 1-8 - 2021
Dedicator of cytokinesis 2 (DOCK2) deficiency is an inborn error of immunity characterized by cellular and humoral immunological abnormalities leading to early-onset infections. We reported a novel case of a 27 months old girl presenting with recurrent pneumonia and a history of skeletal tuberculosis at the age of 19-month-old. Her immunological workup revealed persistent lymphopenia and low CD4 +......
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