HAE therapies: past present and futureAllergy, Asthma & Clinical Immunology - Tập 6 - Trang 1-8 - 2010
Bruce L Zuraw
Advances in understanding the pathophysiology and mechanism of swelling in hereditary angioedema (HAE) has resulted in the development of multiple new drugs for the acute and prophylactic treatment of patients with HAE. This review will recap the past treatment options, review the new current treatment options, and discuss potential future treatment options for patients with HAE.
Prolidase deficiency, a rare inborn error of immunity, clinical phenotypes, immunological features, and proposed treatments in twinsAllergy, Asthma & Clinical Immunology - - 2022
Nora Alrumayyan, Drew Slauenwhite, Sarah M. McAlpine, Susan A. Roberts, Thomas B. Issekutz, Adam M. Huber, Zaiping Liu, Beáta Dérfalvi
AbstractBackgroundProlidase deficiency (PD) is an autosomal recessive inborn multisystemic disease caused by mutations in thePEPDgene encoding the enzyme prolidase D, leading to defects in turnover of proline-containing proteins, such as collagen. PD is categorized as a metabolic disease, but also as an ...... hiện toàn bộ
Local Nasal Specific Immunotherapy for Allergic RhinitisAllergy, Asthma & Clinical Immunology - Tập 2 - Trang 1-7 - 2006
Giovanni Passalacqua, Giorgio Walter Canonica
The possibility of producing local hyposensitization by administering allergens via mucosal routes was envisaged at the beginning of 1900, and local nasal immunotherapy has been extensively studied since the 1970s. Presently, there are 21 randomized controlled trials being conducted with the most common allergens, consistently showing the clinical efficacy of local nasal immunotherapy for rhinitis...... hiện toàn bộ
VIP Regulates the Development & Proliferation of Treg in vivo in spleenAllergy, Asthma & Clinical Immunology - Tập 7 - Trang 1-8 - 2011
Anthony M Szema, Sayyed A Hamidi, Marc G Golightly, Todd P Rueb, John J Chen
Mounting evidence supports a key role for VIP as an anti-inflammatory agent and promoter of immune tolerance. It suppresses TNF-α and other inflammatory cytokines and chemokines, upregulates anti-inflammatory IL-10, and promotes immune tolerant cells called T regulatory (Treg) cells. VIP KO mice have recently been demonstrated to have spontaneous airway and pulmonary perivascular inflammatory resp...... hiện toàn bộ
Staphylococcal enterotoxin B influences the DNA methylation pattern in nasal polyp tissue: a preliminary studyAllergy, Asthma & Clinical Immunology - Tập 9 - Trang 1-5 - 2013
Claudina A Pérez-Novo, Yuan Zhang, Simon Denil, Geert Trooskens, Tim De Meyer, Wim Van Criekinge, Paul Van Cauwenberge, Luo Zhang, Claus Bachert
Staphylococcal enterotoxins may influence the pro-inflammatory pattern of chronic sinus diseases via epigenetic events. This work intended to investigate the potential of staphylococcal enterotoxin B (SEB) to induce changes in the DNA methylation pattern. Nasal polyp tissue explants were cultured in the presence and absence of SEB; genomic DNA was then isolated and used for whole genome methylatio...... hiện toàn bộ
Delivery of subcutaneous immunoglobulin by rapid “push” infusion for primary immunodeficiency patients in Manitoba: a retrospective reviewAllergy, Asthma & Clinical Immunology - Tập 16 - Trang 1-9 - 2020
Graham Walter, Chrystyna Kalicinsky, Richard Warrington, Marianne Miguel, Jeannette Reyes, Tamar S. Rubin
Both intravenous and subcutaneous human immune globin G (IgG) replacement (IVIG and SCIG, respectively) reduce severe infection and increase serum IgG levels in primary immune deficiency disorder (PIDD) patients who require replacement. SCIG can be administered either with the aid of an infusion pump, or by patients or caregivers themselves, using butterfly needles and a syringe (“SCIG push”). SCI...... hiện toàn bộ
A four-way, double-blind, randomized, placebo controlled study to determine the efficacy and speed of azelastine nasal spray, versus loratadine, and cetirizine in adult subjects with allergen-induced seasonal allergic rhinitisAllergy, Asthma & Clinical Immunology - Tập 9 - Trang 1-10 - 2013
Anne K Ellis, Yifei Zhu, Lisa M Steacy, Terry Walker, James H Day
Azelastine has been shown to be effective against seasonal allergic rhinitis (SAR). The Environmental Exposure Unit (EEU) is a validated model of experimental SAR. The objective of this double-blind, four-way crossover study was to evaluate the onset of action of azelastine nasal spray, versus the oral antihistamines loratadine 10 mg and cetirizine 10 mg in the relief of the symptoms of SAR. 70 pa...... hiện toàn bộ