Advances in Therapy
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Effect of timing of glutamine-enriched enteral nutrition on intestinal damage caused by irradiation
Advances in Therapy - Tập 24 - Trang 648-661 - 2007
Intestinal mucosal damage and bacterial translocation are clinical problems that may be caused by the use of ionizing radiation. Glutamine (Gln) support reduces the mucosal barrier in several ways. This study was undertaken to investigate the effect of timing of Gln-enriched enteral nutrition (EN) on bacterial translocation and mucosal damage due to radiotherapy (RT). A rat model of whole body irr......
Safety and Tolerability of Fingolimod in Latin American Patients with Relapsing-Remitting Multiple Sclerosis: The Open-Label FIRST LATAM Study
Advances in Therapy - - 2015
Fingolimod 0.5 mg is an orally active sphingosine 1-phosphate receptor modulator approved for use in adults with relapsing multiple sclerosis (MS). The efficacy and safety profile of fingolimod has been well characterized in a large clinical development program. Here, we report the safety and tolerability of fingolimod in relapsing-remitting MS (RRMS) patients from Latin America. A total of 162 pa......
Mechanisms and Clinical Efficacy of Lixisenatide for the Management of Type 2 Diabetes
Advances in Therapy - Tập 30 Số 2 - Trang 81-101 - 2013
Maintaining Weight Loss by Decreasing Sedentary Time: A Patient and Physician’s Perspective
Advances in Therapy - Tập 34 - Trang 1007-1012 - 2017
This article, co-authored by a patient living with obesity and his obesity medicine specialist, reviews how the patient has successfully lost 200 lb and maintained that loss for over a decade. This was achieved primarily with a behavioral intervention including support visits, a structured food plan, and changes in his physical activity. He did not undergo bariatric surgery. For the majority of th......
Effects of tibolone on abdominal subcutaneous fat, serum leptin levels, and anthropometric indices: A 6-month, prospective, randomized, placebo-controlled, double-blind study
Advances in Therapy - Tập 23 - Trang 926-937 - 2006
This study was undertaken to evaluate the effects of tibolone on abdominal subcutaneous fat, serum leptin levels (SLLs), and anthropometric indices, and to investigate potential relationships between SLLs, subcutaneous abdominal fat thickness, and anthropometric indices in postmenopausal women. In a 6-mo, prospective, randomized, double-blind, placebo-controlled study, 40 healthy postmenopausal wo......
Adherence to Adjuvant Therapy in Patients with Resected Melanoma: An Application of the Theory of Planned Behavior
Advances in Therapy - Tập 39 - Trang 4061-4075 - 2022
Adherence to adjuvant therapy is crucial for effective disease management in patients with resected melanoma. This study assessed patient-reported adherence to adjuvant therapy and identified behavioral/belief constructs associated with adherence in patients with resected melanoma. Patients with resected stage III/IV melanoma were recruited through the Melanoma Research Foundation and a patient pa......
Systematic Review and Meta-analysis of Short- versus Long-Acting Granulocyte Colony-Stimulating Factors for Reduction of Chemotherapy-Induced Febrile Neutropenia
Advances in Therapy - Tập 35 - Trang 1816-1829 - 2018
Short- and long-acting granulocyte-colony stimulating factors (G-CSFs) are approved for the reduction of febrile neutropenia. A systematic literature review was performed to identify randomized controlled trials (RCTs) and non-RCTs reporting the use of G-CSFs following chemotherapy treatment. Medline®/Medline in-process, Embase®, and the Cochrane Library were searched for studies published between......
Effectiveness and Safety of Apixaban vs Warfarin in Patients with Venous Thromboembolism with Risk Factors for Bleeding or for Recurrences
Advances in Therapy - Tập 40 - Trang 1705-1735 - 2023
Patients at increased risk of bleeding and recurrent VTE who develop venous thromboembolism (VTE) present challenges for clinical management. This study evaluated the effectiveness and safety of apixaban vs warfarin in patients with VTE who have risk factors for bleeding or recurrences. Adult patients with VTE initiating apixaban or warfarin were identified from five claims databases. Stabilized ......
Adjunctive Agents for Cervical Preparation in Second Trimester Surgical Abortion
Advances in Therapy - Tập 36 - Trang 1246-1251 - 2019
Late second trimester dilation and evacuation is a challenging subset of surgical abortion. Among the reasons for this is the degree of cervical dilation required to safely extricate fetal parts. Cervical dilation is traditionally achieved by placing multiple sets of osmotic dilators over two or more days prior to the evacuation procedure; however, there is interest in shortening cervical preparat......
Evaluation of MRI-US Fusion Technology in Sports-Related Musculoskeletal Injuries
Advances in Therapy - Tập 32 - Trang 580-594 - 2015
A combination of magnetic resonance imaging (MRI) with real-time high-resolution ultrasound (US) known as fusion imaging may improve visualization of musculoskeletal (MSK) sports medicine injuries. The aim of this study was to evaluate the applicability of MRI-US fusion technology in MSK sports medicine. This study was conducted by the medical services of the FC Barcelona. The participants include......
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