Advances in Rheumatology
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Fibronectin extra domain A as a drug delivery targeting epitope for rheumatoid arthritis
Advances in Rheumatology - - 2022
Abstract Objectives To assess the ability of monoclonal antibodies (mAbs)
specific for fibronectin extra-domain A (FnEDA) to target diseased tissues of
mouse collagen induced arthritis (mCIA) models. To explore the parameters of the
targeting exhibited by anti-FnEDA mAbs including timing and location. Methods
Targeting capabilities of anti-FnEDA mAbs were demonstrated by biodistribution
study wher...
Safety and immunogenicity of influenza A(H3N2) component vaccine in juvenile systemic lupus erythematosus
Advances in Rheumatology - Tập 63 - Trang 1-7 - 2023
Seasonal influenza A (H3N2) virus is an important cause of morbidity and
mortality in the last 50 years in population that is greater than the impact of
H1N1. Data assessing immunogenicity and safety of this virus component in
juvenile systemic lupus erythematosus (JSLE) is lacking in the literature. To
evaluate short-term immunogenicity and safety of influenza A/Singapore (H3N2)
vaccine in JSLE. ...
Microparticles: potential new contributors to the pathogenesis of systemic sclerosis?
Advances in Rheumatology - Tập 63 - Trang 1-8 - 2023
Microparticles (MPs) are membrane-derived vesicles released from cells
undergoing activation or apoptosis with diverse proinflammatory and
prothrombotic activities, that have been implicated in the pathogenesis of
systemic sclerosis (SSc). We aimed to evaluate the plasma levels of
platelet-derived microparticles (PMPs), endothelial cell-derived microparticles
(EMPs), and monocyte-derived micropart...
Prevalence of juvenile idiopathic arthritis in schoolchildren from the city of São Paulo, the largest city in Latin America
Advances in Rheumatology - Tập 59 - Trang 1-7 - 2019
Juvenile idiopathic arthritis (JIA) is a chronic inflammatory disease that
affects children and adolescents. Its prevalence varies greatly from one study
to another according to the population and methodology. Some tools may be
helpful in screening for suspected cases. The aim of this study is determine the
prevalence of JIA in children and adolescent students in the city of São Paulo,
Brazil. Thi...
Cardiovascular risk assessment using ASCVD risk score in fibromyalgia: a single-centre, retrospective study using “traditional” case control methodology and “novel” machine learning
Advances in Rheumatology - Tập 61 - Trang 1-9 - 2021
In autoimmune inflammatory rheumatological diseases, routine cardiovascular risk
assessment is becoming more important. As an increased cardiovascular disease
(CVD) risk is recognized in patients with fibromyalgia (FM), a combination of
traditional CVD risk assessment tool with Machine Learning (ML) predictive model
could help to identify non-traditional CVD risk factors. This study was a
retrospe...
Relationship of the sacral slope with early gait derangements in robust older women
Advances in Rheumatology - Tập 61 - Trang 1-9 - 2021
Trunk pelvic dissociation is fundamental to the compensatory mechanism for
muscle weakness during body bending. We carried out an early investigation of
gait changes in a sample of community-dwelling women ≥60 years without gait
complaints. The primary objective was to correlate spine and pelvic angles with
performance tests and accelerometry parameters. The secondary objective was to
correlate pe...
Platelet/lymphocyte ratio and mean platelet volume in patients with granulomatosis with polyangiitis
Advances in Rheumatology - Tập 60 - Trang 1-6 - 2019
Granulomatosis with polyangiitis (GPA) is a granulomatous necrotizing vasculitis
with high morbidity and mortality. Anti-neutrophil cytoplasmic antibody is a
valuable diagnostic marker, however its titer lacks predictive value for the
severity of organ involvement. Platelet to lymphocyte ratio (PLR) and mean
platelet volume (MPV) has been regarded as a potential marker in assessing
systemic inflam...
Serum defensin levels in patients with systemic sclerosis
Advances in Rheumatology - Tập 60 - Trang 1-5 - 2020
Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of
skin and lung as well as involvement of kidney, gastrointestinal system and
heart. Aetiology and exact mechanism of disease is poorly understood. The
association between antimicrobial peptides (AMPs) and other diseases such as
idiopathic pulmonary fibrosis, diffuse panbronchiolitis, pulmoner alveolar
proteinosis and pso...
Cardiovascular risk comorbidities in rheumatoid arthritis patients and the use of anti-rheumatic drugs: a cross-sectional real-life study
Advances in Rheumatology - Tập 61 - Trang 1-9 - 2021
Rheumatoid arthritis (RA) is a common autoimmune systemic inflammatory disease.
In addition to joint involvement, RA patients frequently have other
comorbidities, such as cardiovascular diseases. Drugs used for RA treatment may
increase or decrease the risk of a cardiovascular event. This study aims to
analyze cardiovascular risk comorbidities in patients with RA and the
correlation with the use o...
Clinical characteristics and risk factors for gout flare during the postsurgical period
Advances in Rheumatology - Tập 59 Số 1 - 2019
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