unc-8, a DEG/ENaC Family Member, Encodes a Subunit of a Candidate Mechanically Gated Channel That Modulates C. elegans Locomotion

Altschul, 1990, Basic local alignment tool, J. Mol. Biol, 215, 403, 10.1016/S0022-2836(05)80360-2

Awayda, 1995, A cloned renal epithelial Na+ channel protein displays stretch activation in planar lipid bilayers, Am. J. Physiol, 268, C1450, 10.1152/ajpcell.1995.268.6.C1450

Barnes, 1994, PCR amplification of up to 35-Kb DNA with high fidelity and high yield from λ bacteriophage templates, Proc. Natl. Acad. Sci. USA, 91, 2216, 10.1073/pnas.91.6.2216

Blount, 1996, Membrane topology and multimeric structure of a mechanosensitive channel protein of Escherichia coli, EMBO J, 15, 4798, 10.1002/j.1460-2075.1996.tb00860.x

Brenner, 1974, The genetics of Caenorhabditis elegans, Genetics, 77, 71, 10.1093/genetics/77.1.71

Canessa, 1993, Functional cloning of the epithelial sodium channel, Nature, 361, 467, 10.1038/361467a0

Canessa, 1994, Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits, Nature, 367, 463, 10.1038/367463a0

Chalfie, 1995, The differentiation and function of the touch receptor neurons of Caenorhabditis elegans, Prog. Brain Res, 105, 179, 10.1016/S0079-6123(08)63293-8

Chalfie, 1981, Developmental genetics of the mechanosensory neurons of Caenorhabditis elegans, Dev. Biol, 82, 358, 10.1016/0012-1606(81)90459-0

Chalfie, 1989, Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons, Science, 243, 1027, 10.1126/science.2646709

Chalfie, 1990, The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans, Nature, 345, 410, 10.1038/345410a0

Chalfie, 1985, The neural circuit for touch sensitivity in C. elegans, J. Neurosci, 5, 956, 10.1523/JNEUROSCI.05-04-00956.1985

Chalfie, 1993, Degenerin similarities, Nature, 361, 504, 10.1038/361504a0

Corey, 1996, Mechanosensation and the DEG/ENaC ion channels, Science, 273, 323, 10.1126/science.273.5273.323

Driscoll, 1995, Methods for the study of cell death in C. elegans, Methods Cell. Biol, 46, 323, 10.1016/S0091-679X(08)61934-2

Driscoll, 1991, The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration, Nature, 349, 588, 10.1038/349588a0

Driscoll, 1997, Mechanotransduction, 645

Du, 1996, Extracellular proteins needed for C. elegans mechanosensation, Neuron, 16, 183, 10.1016/S0896-6273(00)80035-5

Fire, 1990, A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans, Gene, 93, 189, 10.1016/0378-1119(90)90224-F

French, 1992, Mechanotransduction, Annu. Rev. Physiol, 54, 135, 10.1146/annurev.ph.54.030192.001031

García-Añoveros, 1996, Mechanosensation, Curr. Biol, 6, 541, 10.1016/S0960-9822(02)00537-7

García-Añoveros, 1995, Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain, Curr. Biol, 5, 441, 10.1016/S0960-9822(95)00085-6

Genetics Computer Group. Program manual version 8-OpenVMS. (1994). (Madison, Wisconsin: Genetics Computer Group).

Gu, 1996, Genetic interactions affecting touch sensitivity in Caenorhabditis elegans, Proc. Natl. Acad. Sci. USA, 93, 6577, 10.1073/pnas.93.13.6577

Hall, 1997, Neuropathology of degenerative cell death in C. elegans, J. Neurosci. In press, 10.1523/JNEUROSCI.17-03-01033.1997

Hamill, 1996, The pharmacology of mechanogated membrane ion channels, Pharmacol. Rev, 48, 231

Hart, 1995, A synaptic code for sensory modalities revealed by analysis of the C. elegans GLR-1 glutamate receptor, Nature, 378, 82, 10.1038/378082a0

Hong, 1994, A transmembrane domain of the putative channel subunit of MEC-4 influences mechanotransduction and neurodegeneration in C. elegans, Nature, 367, 470, 10.1038/367470a0

Huang, 1994, Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans, Nature, 367, 467, 10.1038/367467a0

Huang, 1995, A stomatin-like protein necessary for mechanosensation in C. elegans, Nature, 378, 292, 10.1038/378292a0

Hudspeth, 1989, How the ear's works work, Nature, 341, 397, 10.1038/341397a0

Kaplan, 1993, A dual mechanosensory and chemosensory neuron in C. elegans, Proc. Natl. Acad. Sci. USA, 90, 2227, 10.1073/pnas.90.6.2227

Kari, 1995, Gamma ray–induced integration of extrachromosomal arrays, 467

Kramer, 1990, The Caenorhabditis elegans rol-6 gene, which interacts with the sqt-1 collagen gene to determine organismal morphology, encodes a collagen, Mol. Cell. Biol, 10, 2081

Lai, 1996, Sequence and transmembrane topology of MEC-4, an ion channel subunit required for mechanotransduction in C. elegans, J. Cell Biol, 133, 1071, 10.1083/jcb.133.5.1071

Lingueglia, 1995, Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel, Nature, 378, 730, 10.1038/378730a0

Liu, 1996, Interaction between a putative mechanosensory membrane channel and a collagen, Science, 273, 361, 10.1126/science.273.5273.361

McIntire, 1993, Genes required for GABA function in Caenorhabditis elegans, Nature, 364, 334, 10.1038/364334a0

McIntire, 1993, GABAergic nervous system of Caenorhabditis elegans, Nature, 364, 337, 10.1038/364337a0

Mello, 1992, Efficient gene transfer in C. elegans, EMBO J, 10, 3959, 10.1002/j.1460-2075.1991.tb04966.x

Mitani, 1993, Combinatorial control of touch receptor neurons expression in Caenorhabditis elegans, Development, 119, 773, 10.1242/dev.119.3.773

Needleman, 1970, A general method applicable to the search for similarities in the amino acid sequence of two proteins, J. Mol. Biol, 48, 443, 10.1016/0022-2836(70)90057-4

Palmer, 1992, Epithelial Na+ channels, Annu. Rev. Physiol, 54, 51, 10.1146/annurev.ph.54.030192.000411

Park, 1986, Mutations with dominant effects on the behavior and morphology of the nematode C. elegans, Genetics, 113, 821, 10.1093/genetics/113.4.821

Park, 1986, C. elegans unc-105 mutations affect muscle and are suppressed by other mutations that affect muscle, Genetics, 113, 853, 10.1093/genetics/113.4.853

Pickles, 1992, Mechanoelectrical transduction by hair cells, Trends Neurosci, 15, 254, 10.1016/0166-2236(92)90066-H

Plasterk, 1995, Reverse genetics, 467

Rossier, 1994, Epithelial sodium channels, Curr. Opin. Nephrol. Hypertens, 3, 487, 10.1097/00041552-199409000-00003

Sackin, 1995, Mechanosensitive channels, Annu. Rev. Physiol, 57, 333, 10.1146/annurev.ph.57.030195.002001

Sambrook, 1989

Shreffler, 1997, Genes controlling ion permeability in both motorneurons and muscle, Behavior. Genet. In press, 10.1023/A:1025605929373

Shreffler, 1995, The unc-8 and sup-40 genes regulate ion channel function in Caenorhabditis elegans motorneurons, Genetics, 139, 1261, 10.1093/genetics/139.3.1261

Sukharev, 1994, A large conductance mechanosensitive channel in E. coli encoded by mscL alone, Nature, 368, 265, 10.1038/368265a0

Sulston, 1977, Post-embryonic cell lineages of the nematodeCaenorhabditis elegans, Dev. Biol, 56, 110, 10.1016/0012-1606(77)90158-0

Sulston, 1983, The embryonic cell lineage of the nematode Caenorhabditis elegans, Dev. Biol, 100, 64, 10.1016/0012-1606(83)90201-4

Sulston, 1992, The C. elegans genome sequencing project, Nature, 356, 37, 10.1038/356037a0

Waldmann, 1995, Functional degenerin-containing chimeras identify residues essential for amiloride-sensitive Na+ channel function, J. Biol. Chem, 270, 11735, 10.1074/jbc.270.20.11735

Waldmann, 1996, The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans, J. Biol. Chem, 271, 10433, 10.1074/jbc.271.18.10433

Way, 1989, The mec-3 gene of Caenorhabditis elegans requires its own product for maintained expression and is expressed in three neuronal cell types, Genes Dev, 3, 1823, 10.1101/gad.3.12a.1823

Wilson, 1994, 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans, Nature, 368, 32, 10.1038/368032a0

White, 1986, The structure of the nervous system of Caenorhabditis elegans, Philos. Trans. R. Soc. Lond. [Biol.], 314, 1

White, 1992, Mutations in the Caenorhabditis elegans unc-4 gene alter the synaptic input to ventral cord motor neurons, Nature, 355, 838, 10.1038/355838a0