uc.454 Inhibited Growth by Targeting Heat Shock Protein Family A Member 12B in Non-Small-Cell Lung Cancer

Siegel, 2012, Cancer statistics, 2012, CA Cancer J. Clin., 62, 10, 10.3322/caac.20138 Peng, 2013, Transcribed ultraconserved region in human cancers, RNA Biol., 10, 1771, 10.4161/rna.26995 Baira, 2008, Ultraconserved elements: genomics, function and disease, RNA Biol., 5, 132, 10.4161/rna.5.3.6673 McCormack, 2012, Ultraconserved elements are novel phylogenomic markers that resolve placental mammal phylogeny when combined with species-tree analysis, Genome Res., 22, 746, 10.1101/gr.125864.111 Katzman, 2007, Human genome ultraconserved elements are ultraselected, Science, 317, 915, 10.1126/science.1142430 Ni, 2007, Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay, Genes Dev., 21, 708, 10.1101/gad.1525507 Calin, 2007, Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas, Cancer Cell, 12, 215, 10.1016/j.ccr.2007.07.027 Li, 2016, Uc.206 regulates cell proliferation and apoptosis by targeting P53 in cervical cancer cells, Neoplasma, 63, 411, 10.4149/310_151017N538 Nan, 2016, A transcribed ultraconserved noncoding RNA, Uc.173, is a key molecule for the inhibition of lead-induced neuronal apoptosis, Oncotarget, 7, 112, 10.18632/oncotarget.6590 Chen, 2007, The strength of selection on ultraconserved elements in the human genome, Am. J. Hum. Genet., 80, 692, 10.1086/513149 Olivieri, 2016, Long non-coding RNA containing ultraconserved genomic region 8 promotes bladder cancer tumorigenesis, Oncotarget, 7, 20636, 10.18632/oncotarget.7833 Hudson, 2013, Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer, Mol. Cancer, 12, 13, 10.1186/1476-4598-12-13 Wang, 2017, TUC.338 promotes invasion and metastasis in colorectal cancer, Int. J. Cancer, 140, 1457, 10.1002/ijc.30542 Ulitsky, 2013, lincRNAs: genomics, evolution, and mechanisms, Cell, 154, 26, 10.1016/j.cell.2013.06.020 Sun, 2015, Discovery, annotation, and functional analysis of long noncoding RNAs controlling cell-cycle gene expression and proliferation in breast cancer cells, Mol. Cell, 59, 698, 10.1016/j.molcel.2015.06.023 Xing, 2014, lncRNA directs cooperative epigenetic regulation downstream of chemokine signals, Cell, 159, 1110, 10.1016/j.cell.2014.10.013 Hudson, 2013, Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer, Mol. Cancer, 12, 13, 10.1186/1476-4598-12-13 Poliseno, 2010, A coding-independent function of gene and pseudogene mRNAs regulates tumour biology, Nature, 465, 1033, 10.1038/nature09144 Ferdin, 2013, HINCUTs in cancer: hypoxia-induced noncoding ultraconserved transcripts, Cell Death Differ., 20, 1675, 10.1038/cdd.2013.119 Martin, 2004, Long-range comparison of human and mouse Sprr loci to identify conserved noncoding sequences involved in coordinate regulation, Genome Res., 14, 2430, 10.1101/gr.2709404 Bo, 2016, Long noncoding RNA uc.338 promotes cell proliferation through association with BMI1 in hepatocellular carcinoma, Hum. Cell, 29, 141, 10.1007/s13577-016-0140-z Sana, 2012, Expression levels of transcribed ultraconserved regions uc.73 and uc.388 are altered in colorectal cancer, Oncology, 82, 114, 10.1159/000336479 Chiang, 2008, Ultraconserved elements: analyses of dosage sensitivity, motifs and boundaries, Genetics, 180, 2277, 10.1534/genetics.108.096537 Chen, 2017, Heat shock protein A12B protects vascular endothelial cells against sepsis-induced acute lung injury in mice, Cell. Physiol. Biochem., 42, 156, 10.1159/000477308 Sun, 2016, Retraction, Am. J. Transl. Res., 8, 1625 Zouein, 2013, HSPA12B and repairing the heart: beauty in simplicity, Cardiovasc. Res., 99, 587, 10.1093/cvr/cvt185 Li, 2015, HSPA12B regulates SSeCKS-mediated astrocyte inflammatory activation in neuroinflammation, Exp. Cell Res., 339, 310, 10.1016/j.yexcr.2015.09.020 Ma, 2015, HSPA12B: a novel facilitator of lung tumor growth, Oncotarget, 6, 9924, 10.18632/oncotarget.3533 Williams, 2015, Bcl-2 family proteins in breast development and cancer: could Mcl-1 targeting overcome therapeutic resistance?, Oncotarget, 6, 3519, 10.18632/oncotarget.2792 Petry, 2010, ERBB2 induces an antiapoptotic expression pattern of Bcl-2 family members in node-negative breast cancer, Clin. Cancer Res., 16, 451, 10.1158/1078-0432.CCR-09-1617 Cotter, 2009, Apoptosis and cancer: the genesis of a research field, Nat. Rev. Cancer, 9, 501, 10.1038/nrc2663 Yang, 2004, Effect of NF-kappaB, survivin, Bcl-2 and Caspase3 on apoptosis of gastric cancer cells induced by tumor necrosis factor related apoptosis inducing ligand, World J. Gastroenterol., 10, 22, 10.3748/wjg.v10.i1.22 Sharifi, 2014, Roles of the Bcl-2/Bax ratio, caspase-8 and 9 in resistance of breast cancer cells to paclitaxel, Asian Pac. J. Cancer Prev., 15, 8617, 10.7314/APJCP.2014.15.20.8617 Lakhani, 2006, Caspases 3 and 7: key mediators of mitochondrial events of apoptosis, Science, 311, 847, 10.1126/science.1115035