siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes

ACS Chemical Biology - Tập 10 Số 5 - Trang 1181-1187 - 2015
Shigeo Matsuda1, Kristofer Keiser1, Jayaprakash K. Nair1, Klaus Charissé1, Rajar M. Manoharan1, Philip Kretschmer1, Chang Geng Peng1, Alexander V. Kel’in1, Kandasamy Pachamuthu1, Jennifer L. S. Willoughby1, Abigail Liebow1, William Querbes1, Kristina Yucius1, Tuyen Nguyen1, Stuart Milstein1, Martin A. Maier1, Kallanthottathil G. Rajeev1, Muthiah Manoharan1
1Alnylam Pharmaceuticals, 300 Third Street, Cambridge, Massachusetts 02142, United States

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