rBTI induces apoptosis in human solid tumor cell lines by loss in mitochondrial transmembrane potential and caspase activation

Ashkenazi, 1998, Death receptors: signaling and modulation, Science, 281, 1305, 10.1126/science.281.5381.1305 Azzouz, 2005, Effects of plant protease inhibitors, oryzacystatin I and soybean Bowman–Birk inhibitor, on the aphid Macrosiphum euphorbiae (Homoptera, Aphididae) and its parasitoid Aphelinus abdominalis (Hymenoptera, Apheinidae), J. Insect Physiol., 51, 75, 10.1016/j.jinsphys.2004.11.010 Belozersky, 1995, Complete amino acid sequence of the protease inhibitor from buckwheat seeds, FEBS Lett., 371, 264, 10.1016/0014-5793(95)00899-K Bossy-Wetzel, 1999, Caspases induce cytochrome c release from mitochondria by activating cytosolic factors, J. Biol. Chem., 274, 17484, 10.1074/jbc.274.25.17484 Cohen, 1997, Caspases: the executioners of apoptosis, Biochem. J., 326, 1, 10.1042/bj3260001 Darzynkiewicz, 1992, Features of apoptotic cells measured by flow cytometry, Cytometry, 13, 795, 10.1002/cyto.990130802 Dunaevsky, 1997, The anionic protease BWI-1 from buckwheat seeds. Kinetic properties and possible roles, Physiol. Plant, 101, 483, 10.1111/j.1399-3054.1997.tb01027.x Enari, 1995, Involvement of an ICE-like protease in Fas-mediated apoptosis, Nature, 375, 78, 10.1038/375078a0 Foehr, 1999, Antiapoptotic activity of the Bowman–Birk inhibitor can be attributed to copurified phospholipids, Nutr. Cancer, 34, 199, 10.1207/S15327914NC3402_11 Gladysheva, 2001, Immunoconjugates of soybean Bowman–Birk protease inhibitor as targeted antitumor polymeric agents, J. Drug Target, 9, 303, 10.3109/10611860108998767 Green, 1998, Mitochondria and apoptosis, Science, 281, 1309, 10.1126/science.281.5381.1309 Herrmann, 1994, A rapid and simple method for the isolation of apoptotic DNA fragments, Nucleic Acids Res., 22, 5506, 10.1093/nar/22.24.5506 Huang, 2000, BH3-only proteins-essential initiators of apoptotic cell death, Cell, 103, 839, 10.1016/S0092-8674(00)00187-2 Inoue, 2005, Protective role of urinary trypsin inhibitor in acute lung injury induced by lipopolysaccharide, Exp. Biol. Med. (Maywood), 230, 281, 10.1177/153537020523000408 Jacotot, 1999, Mitochondrial membrane permeabilization during the apoptotic process, Ann. N.Y. Acad. Sci., 887, 18, 10.1111/j.1749-6632.1999.tb07919.x Khosravi-Far, 2004, Death receptor signals to mitochondria, Cancer Biol. Ther., 3, 1051, 10.4161/cbt.3.11.1173 Kroemer, 2000, Mitochondrial control of cell death, Nat. Med., 6, 513, 10.1038/74994 Li, 1997, Cytochrome c and dATP dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade, Cell, 91, 479, 10.1016/S0092-8674(00)80434-1 Li, 2006, Cloning and characterization of a novel trypsin inhibitor (BTIw1) gene from Fagopyrum esculentum, DNA Seq., 17, 203, 10.1080/10425170600699760 Liu, 1996, Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c, Cell, 86, 147, 10.1016/S0092-8674(00)80085-9 Lockshin, 2004, Apoptosis, autophagy, and more, Int. J. Biochem. Cell Biol., 36, 2405, 10.1016/j.biocel.2004.04.011 Malkowicz, 2003, Effect of the Bowman–Birk inhibitor (a soy protein) on in vitro bladder neck/urethral and penile corporal smooth muscle activity, Neurourol. Urodyn., 22, 54, 10.1002/nau.10071 Marchetti, 1996, Mitochondrial permeability transition is a central coordinating event of apoptosis, J. Exp. Med., 184, 1155, 10.1084/jem.184.3.1155 Nagata, 2000, Apoptotic DNA fragmentation, Exp. Cell Res., 256, 12, 10.1006/excr.2000.4834 Nakazawa, 2003, ARF tumor suppressor induces mitochondria-dependent apoptosis by modulation of mitochondrial Bcl-2 family proteins, J. Biol. Chem., 278, 27888, 10.1074/jbc.M300510200 Newmeyer, 2003, Mitochondria: releasing power for life and unleashing the machineries of death, Cell, 112, 481, 10.1016/S0092-8674(03)00116-8 Park, 1997, Primary structure and allergenic activity of trypsin inhibitors from the seeds of buckwheat (Fagopyrum esculentum Moench), FEBS Lett., 400, 103, 10.1016/S0014-5793(96)01367-1 Park, 2004, Suppressive activity of protease inhibitors from buckwheat seeds against human T-acute lymphoblastic leukemia cell lines, Appl. Biochem. Biotechnol., 117, 65, 10.1385/ABAB:117:2:065 Pomeranz, 1983, Buckwheat: structure, composition, and utilization, Crit. Rev. Food Sci. Nutr., 19, 213, 10.1080/10408398309527376 Ryan, 1990, Protease inhibitors in plants: genes for improving defenses against insect and pathogens, Annu. Rev. Phytophathol., 28, 425, 10.1146/annurev.py.28.090190.002233 Salvesen, 1997, Caspases: intracellular signaling by proteolysis, Cell, 91, 443, 10.1016/S0092-8674(00)80430-4 Skrabanja, 2001, Nutritional properties of starch in buckwheat products: studies in vitro and in vivo, J. Agric. Food Chem., 49, 490, 10.1021/jf000779w Stennicke, 1998, Properties of the caspases, Biochem. Biophys. Acta, 1387, 17, 10.1016/S0167-4838(98)00133-2 Wang, 2001, The expanding role of mitochondria in apoptosis, Genes Dev., 15, 2922 Wang, 2007, Induction of apoptosis by Buckwheat trypsin inhibitor in chronic myeloid leukemia K562 cells, Biol. Pharm. Bull., 30, 783, 10.1248/bpb.30.783 Wei, 2001, Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death, Science, 292, 727, 10.1126/science.1059108 Yang, 2006, Up-regulation of Bax and endonuclease G, and down-modulation of Bcl-XL involved in cardiotoxin III-induced apoptosis in K562 cells, Exp. Mol. Med., 38, 435, 10.1038/emm.2006.51 Zhang, 2007, Expression of Buckwheat trypsin inhibitor gene in Escherichia coli and its effect on multiple myeloma IM-9 cell proliferation, Acta. Biochem. Biophys. Sin., 39, 701, 10.1111/j.1745-7270.2007.00332.x