pH‐temperature Responsive Hydrogel‐Mediated Delivery of Exendin‐4 Encapsulated Chitosan Nanospheres for Sustained Therapeutic Efficacy in Type 2 Diabetes Mellitus

Macromolecular Bioscience - Tập 23 Số 11 - 2023
Thuy An Trinh1, Thai Minh Duy Le2, Hien Thi‐Thanh Nguyen3, Thanh Loc Nguyen1, Jaeyun Kim1, Dai Phu Huynh4,5, Thavasyappan Thambi1,6
1School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea
2Department of Bioengineering, College of Engineering, Hanyang University, Seoul, 04763 South Korea
3Faculty of Chemical Engineering, Ho Chi Minh City University of Technology, 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, 0084 Vietnam
4National Key Laboratory of Polymer and Composite Materials, Research Center for Polymeric Materials, Ho Chi Minh University of Technology, 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, 0084 Vietnam
5Vietnam National University – Ho Chi Minh City, Linh Trung Ward, Thu Duc District, Ho Chi Minh City, 700000, Vietnam
6Theranostic Macromolecules Research Center, Sungkyunkwan University, Suwon 16419, Republic of Korea

Tóm tắt

AbstractType 2 Diabetes Mellitus (T2D) is a chronic, obesity‐related, and inflammatory disorder characterize by insulin resistance, inadequate insulin secretion, hyperglycemia, and excessive glucagon secretion. Exendin‐4 (EX), a clinically established antidiabetic medication that acts as a glucagon‐like peptide‐1 receptor agonist, is effective in lowering glucose levels and stimulating insulin secretion while significantly reducing hunger. However, the requirement for multiple daily injections due to EX's short half‐life is a significant limitation in its clinical application, leading to high treatment costs and patient inconvenience. To address this issue, an injectable hydrogel system is developed that can provide sustained EX release at the injection site, reducing the need for daily injections. In this study, the electrospray technique is examine to form EX@CS nanospheres by electrostatic interaction between cationic chitosan (CS) and negatively charged EX. These nanospheres are uniformly dispersed in a pH‐temperature responsive pentablock copolymer, which forms micelles and undergoes sol‐to‐gel transition at physiological conditions. Following injection, the hydrogel gradually degraded, exhibiting excellent biocompatibility. The EX@CS nanospheres are subsequently released, maintaining therapeutic levels for over 72 h compared to free EX solution. The findings demonstrate that the pH‐temperature responsive hydrogel system containing EX@CS nanospheres can be a promising platform for the treatment of T2D.

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Macromolecular Bioscience

Tập 23 Số 11

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