pH-sensing hybrid hydrogels for non-invasive metabolism monitoring in tumor spheroids

Materials Today Bio - Tập 20 - Trang 100655 - 2023
Riccardo Rizzo1, Valentina Onesto1, Giulia Morello2,1, Helena Iuele1, Francesca Scalera1, Stefania Forciniti1, Giuseppe Gigli2,1, Alessandro Polini1, Francesca Gervaso1, Loretta L. del Mercato1
1Institute of Nanotechnology, National Research Council (CNR-NANOTEC), c/o Campus Ecotekne, via Monteroni, 73100, Lecce, Italy
2Department of Mathematics and Physics ''Ennio De Giorgi", University of Salento, C/o Campus Ecotekne, Via Monteroni, 73100, Lecce, Italy

Tóm tắt

Từ khóa


Tài liệu tham khảo

Bray, 2018, Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, Ca - Cancer J. Clin., 68, 394, 10.3322/caac.21492

Siegel, 2019, Cancer statistics, Ca - Cancer J. Clin., 69, 7, 10.3322/caac.21551

Griffin-Sobel, 2017, Gastrointestinal cancers: screening and early detection, Semin. Oncol. Nurs., 33, 165, 10.1016/j.soncn.2017.02.004

Castro, 2021, Advances on colorectal cancer 3D models: the needed translational technology for nanomedicine screening, Adv. Drug Deliv. Rev., 175, 10.1016/j.addr.2021.06.001

Thiele, 2014, 25th anniversary article: designer hydrogels for cell cultures: a materials selection guide, Adv. Mater., 26, 125, 10.1002/adma.201302958

Kamb, 2005, What's wrong with our cancer models?, Nat. Rev. Drug Discov., 4, 161, 10.1038/nrd1635

Kapałczyńska, 2018, 2D and 3D cell cultures – a comparison of different types of cancer cell cultures, Arch. Med. Sci., 14, 910

Thakuri, 2018, Biomaterials-based approaches to tumor spheroid and organoid modeling, Adv Healthc Mater, 7, 10.1002/adhm.201700980

Reidy, 2021, A 3D view of colorectal cancer models in predicting therapeutic responses and resistance, Cancers, 13, 1, 10.3390/cancers13020227

Cavo, 2020, A synergic approach to enhance long-term culture and manipulation of MiaPaCa-2 pancreatic cancer spheroids, Sci. Rep., 10, 1, 10.1038/s41598-020-66908-8

Laschke, 2017, Life is 3D: boosting spheroid function for tissue engineering, Trends Biotechnol., 35, 133, 10.1016/j.tibtech.2016.08.004

Blondel, 2019, Bioinspired hydrogels for 3D organoid culture, Chimia, 73, 81, 10.2533/chimia.2019.81

Aisenbrey, 2020, Synthetic alternatives to Matrigel, Nat. Rev. Mater., 5, 539, 10.1038/s41578-020-0199-8

Thiele, 2014, 25th anniversary article: designer hydrogels for cell cultures: a materials selection guide, Adv. Mater., 26, 125, 10.1002/adma.201302958

Dhand, 2021, Enhancing biopolymer hydrogel functionality through interpenetrating networks, Trends Biotechnol., 39, 519, 10.1016/j.tibtech.2020.08.007

Liu, 2019, Advances in hydrogels in organoids and organs-on-a-chip, Adv. Mater., 31, 10.1002/adma.201902042

Morello, 2021, Preparation and characterization of salt-mediated injectable thermosensitive chitosan/pectin hydrogels for cell embedding and culturing, Polymers, 13, 2674, 10.3390/polym13162674

Morello, 2021, A thermo-sensitive chitosan/pectin hydrogel for long-term tumor spheroid culture, Carbohydr. Polym., 274, 10.1016/j.carbpol.2021.118633

Morello, 2023, Chitosan and pectin hydrogels for tissue engineering and in vitro modeling, Gels, 9, 132, 10.3390/gels9020132

Zarandona, 2021, 3D printed chitosan-pectin hydrogels: from rheological characterization to scaffold development and assessment, Gels, 7, 175, 10.3390/gels7040175

Matricardi, 2013, Interpenetrating Polymer Networks polysaccharide hydrogels for drug delivery and tissue engineering, Adv. Drug Deliv. Rev., 65, 1172, 10.1016/j.addr.2013.04.002

Jing, 2019, Role of hypoxia in cancer therapy by regulating the tumor microenvironment, Mol. Cancer, 18, 157, 10.1186/s12943-019-1089-9

Prasad, 2020, Optical and magnetic resonance imaging approaches for investigating the tumour microenvironment: state-of-the-art review and future trends, Nanotechnology, 32

Dharmaratne, 2021, Targeting the hypoxic and acidic tumor microenvironment with pH-sensitive peptides, Cells, 10, 1, 10.3390/cells10030541

Corbet, 2017, Tumour acidosis: from the passenger to the driver's seat, Nat. Rev. Cancer, 17, 577, 10.1038/nrc.2017.77

Piasentin, 2020, The control of acidity in tumor cells: a biophysical model, Sci. Rep., 10, 1, 10.1038/s41598-020-70396-1

Boedtkjer, 2012, Physiology, pharmacology and pathophysiology of the pH regulatory transport proteins NHE1 and NBCn1: similarities, differences, and implications for cancer therapy, Curr. Pharmaceut. Des., 18, 1345, 10.2174/138161212799504830

Swietach, 2014, The chemistry, physiology and pathology of pH in cancer, Phil. Trans. Biol. Sci., 369, 10.1098/rstb.2013.0099

Serio, 2021, Electrospun polyvinyl-alcohol/gum Arabic nanofibers: biomimetic platform for in vitro cell growth and cancer nanomedicine delivery, Int. J. Biol. Macromol., 188, 764, 10.1016/j.ijbiomac.2021.08.069

Serio, 2022, Co-loading of doxorubicin and iron oxide nanocubes in polycaprolactone fibers for combining Magneto-Thermal and chemotherapeutic effects on cancer cells, J. Colloid Interface Sci., 607, 34, 10.1016/j.jcis.2021.08.153

Cave, 2021, The revolutionary roads to study cell-cell interactions in 3D in vitro pancreatic cancer models, Cancers, 13, 1

Turetta, 2018, Emerging Technologies for cancer research: towards personalized medicine with microfluidic platforms and 3D tumor models, Curr. Med. Chem., 25, 4616, 10.2174/0929867325666180605122633

Cavo, 2020, Electrospun nanofibers in cancer research: from engineering of in vitro 3D cancer models to therapy, Biomater. Sci., 8, 4887, 10.1039/D0BM00390E

Piper, 2008, Characterization and application of controllable local chemical changes produced by reagent delivery from a nanopipet, J. Am. Chem. Soc., 130, 10386, 10.1021/ja8022253

Parks, 2011, pH control mechanisms of tumor survival and growth, J. Cell. Physiol., 226, 299, 10.1002/jcp.22400

Gu, 2021, Measurement of mitochondrial respiration in adherent cells by Seahorse XF96 cell mito stress test, STAR Protoc, 2, 10.1016/j.xpro.2020.100245

Zhang, 2019, High-resolution label-free 3D mapping of extracellular pH of single living cells, Nat. Commun., 10, 5610, 10.1038/s41467-019-13535-1

Anemone, 2019, Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH, Cancer Metastasis Rev., 38, 25, 10.1007/s10555-019-09782-9

Jaworska, 2021, Intracellular pH – advantages and pitfalls of surface-enhanced Raman scattering and fluorescence microscopy – a review, Spectrochim. Acta Mol. Biomol. Spectrosc., 251, 10.1016/j.saa.2020.119410

Pérez-Jiménez, 2020, Surface-enhanced Raman spectroscopy: benefits, trade-offs and future developments, Chem. Sci., 11, 4563, 10.1039/D0SC00809E

Xu, 2018, In situ imaging of live-cell extracellular pH during cell apoptosis with surface-enhanced Raman spectroscopy, Anal. Chem., 90, 13922, 10.1021/acs.analchem.8b03193

Yang, 2019, Fluorescence-SERS dual-signal probes for pH sensing in live cells, Colloids Surf. A Physicochem. Eng. Asp., 562, 289, 10.1016/j.colsurfa.2018.11.036

Xu, 2018, In situ imaging of live-cell extracellular pH during cell apoptosis with surface-enhanced Raman spectroscopy, Anal. Chem., 90, 13922, 10.1021/acs.analchem.8b03193

Chandra, 2020, Fluorescent nanoparticles for sensing, Frontiers of Nanoscience, 16, 117, 10.1016/B978-0-08-102828-5.00006-1

del Mercato, 2016, Design and characterization of microcapsules-integrated collagen matrixes as multifunctional three-dimensional scaffolds for soft tissue engineering, J. Mech. Behav. Biomed. Mater., 62, 209, 10.1016/j.jmbbm.2016.05.009

Moldero, 2020, Probing the pH microenvironment of mesenchymal stromal cell cultures on additive-manufactured scaffolds, Small, 16

Chandra, 2021, Highly sensitive fluorescent pH microsensors based on the ratiometric dye pyranine immobilized on silica microparticles, Chemistry, 27, 13318, 10.1002/chem.202101568

del Mercato, 2015, Ratiometric organic fibers for localized and reversible ion sensing with micrometer-scale spatial resolution, Small, 11, 6417, 10.1002/smll.201502171

de Luca, 2015, Advances in use of capsule-based fluorescent sensors for measuring acidification of endocytic compartments in cells with altered expression of V-ATPase subunit V 1 G 1, ACS Appl. Mater. Interfaces, 7, 15052, 10.1021/acsami.5b04375

Niu, 2015, Ratiometric emission fluorescent pH probe for imaging of living cells in extreme acidity, Anal. Chem., 87, 2788, 10.1021/ac504109h

Onesto, 2023, Probing single-cell fermentation fluxes and exchange networks via pH-sensing hybrid nanofibers, ACS Nano, 17, 3313, 10.1021/acsnano.2c06114

Sjöback, 1995, Absorption and fluorescence properties of fluorescein, Spectrochim. Acta Mol. Biomol. Spectrosc., 51, 10.1016/0584-8539(95)01421-P

Boedtkjer, 2020, The acidic tumor microenvironment as a driver of cancer, Annu. Rev. Physiol., 82, 103, 10.1146/annurev-physiol-021119-034627

Rizzo, 2022, A pH-sensor scaffold for mapping spatiotemporal gradients in three-dimensional in vitro tumour models, Biosens. Bioelectron., 212, 10.1016/j.bios.2022.114401

Offeddu, 2020, Scale and structure dependent solute diffusivity within microporous tissue engineering scaffolds, J. Mater. Sci. Mater. Med., 31, 1, 10.1007/s10856-020-06381-x

Neufeld, 2017, Pectin–chitosan physical hydrogels as potential drug delivery vehicles, Int. J. Biol. Macromol., 101, 852, 10.1016/j.ijbiomac.2017.03.167

Du, 2021, Hydrogel-based optical ion sensors: principles and challenges for point-of-care testing and environmental monitoring, ACS Sens., 6, 1990, 10.1021/acssensors.1c00756

le Guern, 2020, Fluorescein derivatives as fluorescent probes for pH monitoring along recent biological applications, Int. J. Mol. Sci., 21, 1, 10.3390/ijms21239217

Neri, 2011, Interfering with pH regulation in tumours as a therapeutic strategy, Nat. Rev. Drug Discov., 10, 767, 10.1038/nrd3554

Kato, 2013, Acidic extracellular microenvironment and cancer, Cancer Cell Int., 13, 89, 10.1186/1475-2867-13-89

Anderson, 2016, Probe for the measurement of cell surface pH in vivo and ex vivo, Proc. Natl. Acad. Sci. USA, 113, 8177, 10.1073/pnas.1608247113

Altea-Manzano, 2020, Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take, EMBO Rep., 21, 10.15252/embr.202050635

Ding, 2022, Patient-derived micro-organospheres enable clinical precision oncology, Cell Stem Cell, 29, 905, 10.1016/j.stem.2022.04.006

Chandra, 2022, Fully automated computational approach for precisely measuring organelle acidification with optical pH sensors, ACS Appl. Mater. Interfaces, 14, 18133, 10.1021/acsami.2c00389

Kersting, 2020, Subtoxic cell responses to silica particles with different size and shape, Sci. Rep., 10, 10.1038/s41598-020-78550-5

Meyer, 1994, Topographic distance and watershed lines, Signal Process., 38, 113, 10.1016/0165-1684(94)90060-4