p55PIK-PI3K kích thích quá trình hình thành mạch trong tế bào ung thư đại trực tràng thông qua việc kích hoạt con đường NF-κB

Anderson DH (2010) p85 Plays a critical role in controlling flux through the PI3K/PTEN signaling axis through dual regulation of both p110 (PI3K) and PTEN. Cell Cycle 9:2055–2056 Berenjeno IM, Vanhaesebroeck B (2009) PI3K regulatory subunits lose control in cancer. Cancer Cell 16:449–450 Bergers G, Benjamin LE (2003) Tumorigenesis and the angiogenic switch. Nat Rev Cancer 3:401–410 Bikfalvi A (2006) Angiogenesis: health and disease. Ann Oncol 17(Suppl 10):x65–x70 Bunney TD, Katan M (2010) Phosphoinositide signalling in cancer: beyond PI3K and PTEN. Nat Rev Cancer 10:342–352 Carmeliet P (2003) Angiogenesis in health and disease. Nat Med 9:653–660 Cook KM, Figg WD (2010) Angiogenesis inhibitors: current strategies and future prospects. CA Cancer J Clin 60:222–243 Courtney KD, Corcoran RB, Engelman JA (2010) The PI3K pathway as drug target in human cancer. J Clin Oncol 28:1075–1083 Dayan F, Bilton RL, Laferriere J et al (2009) Activation of HIF-1alpha in exponentially growing cells via hypoxic stimulation is independent of the Akt/mTOR pathway. J Cell Physiol 218:167–174 Du J, Xu R, Hu Z et al (2011) PI3K and ERK-induced Rac1 activation mediates hypoxia-induced HIF-1alpha expression in MCF-7 breast cancer cells. PLoS One 6:e25213 Ellis LM, Hicklin DJ (2008) VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer 8:579–591 Eltzschig HK, Carmeliet P (2011) Hypoxia and inflammation. N Engl J Med 364:656–665 Fang J, Ding M, Yang L et al (2007) PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis. Cell Signal 19:2487–2497 Foukas LC, Berenjeno IM, Gray A et al (2010) Activity of any class IA PI3K isoform can sustain cell proliferation and survival. Proc Natl Acad Sci U S A 107:11381–11386 Grothey A, Galanis E (2009) Targeting angiogenesis: progress with anti-VEGF treatment with large molecules. Nat Rev Clin Oncol 6:507–518 Hamada K, Sasaki T, Koni PA et al (2005) The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev 19:2054–2065 Hicklin DJ, Ellis LM (2005) Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23:1011–1027 Hu J, Liu S, Wang J et al (2005) Overexpression of the N-terminal end of the p55gamma regulatory subunit of phosphatidylinositol 3-kinase blocks cell cycle progression in gastric carcinoma cells. Int J Oncol 26:1321–1327 Hu J, Xia X, Cheng A et al (2008) A peptide inhibitor derived from p55PIK phosphatidylinositol 3-kinase regulatory subunit: a novel cancer therapy. Mol Cancer Ther 7:3719–3728 Hubbard J, Grothey A (2010) Antiangiogenesis agents in colorectal cancer. Curr Opin Oncol 22:374–380 Jia S, Liu Z, Zhang S et al (2008) Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature 454:776–779 Jiang BH, Liu LZ (2009) PI3K/PTEN signaling in angiogenesis and tumorigenesis. Adv Cancer Res 102:19–65 Karar J, Maity A (2011) PI3K/AKT/mTOR Pathway in Angiogenesis. Front Mol Neurosci 4:51 Kerbel RS (2008) Tumor angiogenesis. N Engl J Med 358:2039–2049 Kloo B, Nagel D, Pfeifer M et al (2011) Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells. Proc Natl Acad Sci U S A 108:272–277 Lawrence T, Bebien M, Liu GY et al (2005) IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature 434:1138–1143 Marone R, Cmiljanovic V, Giese B et al (2008) Targeting phosphoinositide 3-kinase: moving towards therapy. Biochim Biophys Acta 1784:159–185 Maxwell PH, Dachs GU, Gleadle JM et al (1997) Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci U S A 94:8104–8109 Menakuru SR, Brown NJ, Staton CA et al (2008) Angiogenesis in pre-malignant conditions. Br J Cancer 99:1961–1966 Mitchell DC, Bryan BA (2010) Anti-angiogenic therapy: adapting strategies to overcome resistant tumors. J Cell Biochem 111:543–553 Mylonis I, Chachami G, Paraskeva E et al (2008) Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1alpha by MAPK. J Biol Chem 283:27620–27627 Okumura N, Yoshida H, Kitagishi Y et al (2012) PI3K/AKT/PTEN signaling as a molecular target in leukemia angiogenesis. Adv Hematol 2012:843085 Pufe T, Lemke A, Kurz B et al (2004) Mechanical overload induces VEGF in cartilage discs via hypoxia-inducible factor. Am J Pathol 164:185–192 Rhodes DR, Yu J, Shanker K et al (2004) Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression. Proc Natl Acad Sci U S A 101:9309–9314 Rhodes DR, Yu J, Shanker K et al (2004) ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia 6:1–6 Sakurai H, Chiba H, Miyoshi H et al (1999) IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain. J Biol Chem 274:30353–30356 Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C (T) method. Nat Protoc 3:1101–1108 Skrzypczak M, Goryca K, Rubel T et al (2010) Modeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data directed for maximization of analytical reliability. Plos One 5:e13091 Tian T, Nan KJ, Wang SH et al (2010) PTEN regulates angiogenesis and VEGF expression through phosphatase-dependent and -independent mechanisms in HepG2 cells. Carcinogenesis 31:1211–1219 Tsuzuki Y, Fukumura D, Oosthuyse B et al (2000) Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha–> hypoxia response element–> VEGF cascade differentially regulates vascular response and growth rate in tumors. Cancer Res 60:6248–6252 Van Uden P, Kenneth NS, Rocha S (2008) Regulation of hypoxia-inducible factor-1alpha by NF-kappaB. Biochem J 412:477–484 Vanhaesebroeck B, Guillermet-Guibert J, Graupera M et al (2010) The emerging mechanisms of isoform-specific PI3K signalling. Nat Rev Mol Cell Bio 11:329–341 Wang G, Deng Y, Cao X et al (2012) Blocking p55PIK Signaling inhibits proliferation and induces differentiation of leukemia cells. Cell Death Differ 19:1870–1879 Wee S, Wiederschain D, Maira SM et al (2008) PTEN-deficient cancers depend on PIK3CB. Proc Natl Acad Sci U S A 105:13057–13062 Weidner N, Semple JP, Welch WR et al (1991) Tumor angiogenesis and metastasis–correlation in invasive breast carcinoma. N Engl J Med 324:1–8 Winder T, Lenz HJ (2010) Vascular endothelial growth factor and epidermal growth factor signaling pathways as therapeutic targets for colorectal cancer. Gastroenterology 138:2163–2176 Xia X, Cheng A, Akinmade D et al (2003) The N-terminal 24 amino acids of the p55 gamma regulatory subunit of phosphoinositide 3-kinase binds Rb and induces cell cycle arrest. Mol Cell Biol 23:1717–1725 Yuan TL, Cantley LC (2008) PI3K pathway alterations in cancer: variations on a theme. Oncogene 27:5497–5510 Zhang L, Huang J, Yang N et al (2007) Integrative genomic analysis of phosphatidylinositol 3′-kinase family identifies PIK3R3 as a potential therapeutic target in epithelial ovarian cancer. Clin Cancer Res 13:5314–5321 Zhao L, Vogt PK (2008) Class I PI3K in oncogenic cellular transformation. Oncogene 27:5486–5496