Biểu hiện p53 và p16 trong ung thư biểu mô tế bào vảy và ung thư biểu mô tế bào vảy dạng nền trong khoang miệng

Springer Science and Business Media LLC - Tập 2 - Trang 7-17 - 2018
Allisson Filipe Lopes Martins1, Carlos Henrique Pereira2, Marília Oliveira Morais1, Paulo Otávio Carmo Souza3, Lucas Borges Fleury Fernandes4, Aline Carvalho Batista1, Elismauro Francisco Mendonça1
1Department of Stomatologic Sciences, Oral Pathology, Federal University of Goiás, Goiânia, Brazil
2Araujo Jorge Cancer Hospital, Goiânia, Brazil
3Endodontic Departament, Federal University of Goiás, Goiânia, Brazil
4Department of Bucomaxilofacial Surgery of Clinics Hospital, Federal University of Goiás, Goiânia, Brazil

Tóm tắt

Hành vi xâm lấn thật sự của ung thư biểu mô tế bào vảy trong khoang miệng (SCC) so với ung thư biểu mô tế bào vảy dạng nền (BSCC) đã được tranh luận, và việc nghiên cứu những rối loạn trong protein chu kỳ tế bào có thể giúp hiểu rõ hơn về hành vi sinh học của cả hai biến thể này. Mục tiêu của nghiên cứu này là khảo sát tình trạng p53 và p16 trong 32 mẫu SCC và 16 mẫu BSCC của khoang miệng. Phương pháp nhuộm miễn dịch hóa (immunohistochemistry) đã được sử dụng để đánh giá tình trạng của các protein này. Sự liên kết giữa p53 và p16 với các đặc điểm lâm sàng - bệnh lý và giá trị tiên lượng đã được đánh giá. Một tỷ lệ cao về sự rối loạn p53 đã được quan sát thấy ở cả hai biến thể (84,4% trong 32 mẫu SCC và 81,2% trong 16 mẫu BSCC; p = 0,78). BSCC cho thấy tỷ lệ cao hơn về sự biểu hiện p16 cao (86,7% trong 15 mẫu) so với SCC (61,3% trong 31 mẫu); tuy nhiên, sự khác biệt này không đạt được ý nghĩa thống kê (p = 0,08). Trong biến thể SCC, các trường hợp có biểu hiện p16 cao cho thấy tỷ lệ sống sót tổng thể thấp hơn. Protein p53 có liên quan đến việc sử dụng thuốc lá, nhưng không có các đặc điểm lâm sàng - bệnh lý khác. Kết quả của chúng tôi cho thấy rằng sự rối loạn chu kỳ tế bào p53 và p16 là những phát hiện phổ biến ở SCC trong khoang miệng, cũng như ở BSCC. Tỷ lệ cao hơn về sự biểu hiện quá mức p16 trong các trường hợp BSCC trong khoang miệng có thể liên quan đến quá trình sinh ung thư.

Từ khóa

#p53 #p16 #ung thư vòm miệng #ung thư biểu mô tế bào vảy #ung thư biểu mô tế bào vảy dạng nền

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