microRNA-21 protects against ischemia-reperfusion and hypoxia-reperfusion-induced cardiocyte apoptosis via the phosphatase and tensin homolog/Akt-dependent mechanism

Molecular Medicine Reports - Tập 9 Số 6 - Trang 2213-2220 - 2014
Qiong Yang1, Kan Yang1, Anying Li1
1Department of Cardiology, the Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China

Tóm tắt

Từ khóa


Tài liệu tham khảo

Ganguly, 2013, Differential effects of trans and polyunsaturated fatty acids on ischemia/reperfusion injury and its associated cardiovascular disease states, Curr Pharm Des, 10.2174/138161281939131127111018

Kalogeris, 2012, Cell biology of ischemia/reperfusion injury, Int Rev Cell Mol Biol, 298, 229, 10.1016/B978-0-12-394309-5.00006-7

Xu, 2012, Targeting cell signaling and apoptotic pathways by luteolin: cardioprotective role in rat cardiomyocytes following ischemia/reperfusion, Nutrients, 4, 2008, 10.3390/nu4122008

Guo, 2012, Hydrogen sulfide as an endogenous modulator in mitochondria and mitochondria dysfunction, Oxid Med Cell Longev, 2012, 878052, 10.1155/2012/878052

Ha, 2011, Toll-like receptors: new players in myocardial ischemia/reperfusion injury, Antioxid Redox Signal, 15, 1875, 10.1089/ars.2010.3723

Young, 2012, Hyperoxia: a review of the risks and benefits in adult cardiac surgery, J Extra Corpor Technol, 44, 241, 10.1051/ject/201244241

Nagai, 2010, Impact of systemic acidosis on the development of malignant ventricular arrhythmias after reperfusion therapy for ST-elevation myocardial infarction, Circ J, 74, 1808, 10.1253/circj.CJ-10-0229

Porrello, 2013, microRNAs in cardiac development and regeneration, Clin Sci (Lond), 125, 151, 10.1042/CS20130011

Chen, 2012, Roles of microRNAs in atherosclerosis and restenosis, J Biomed Sci, 19, 79, 10.1186/1423-0127-19-79

Zhu, 2012, Role of microRNAs in the reperfused myocardium towards post-infarct remodelling, Cardiovasc Res, 94, 284, 10.1093/cvr/cvr291

Yang, 2012, Combined deep microRNA and mRNA sequencing identifies protective transcriptomal signature of enhanced PI3Kalpha signaling in cardiac hypertrophy, J Mol Cell Cardiol, 53, 101, 10.1016/j.yjmcc.2012.04.012

Cheng, 2010, MicroRNA-21 in cardiovascular disease, J Cardiovasc Transl Res, 3, 251, 10.1007/s12265-010-9169-7

Hers, 2011, Akt signalling in health and disease, Cell Signal, 23, 1515, 10.1016/j.cellsig.2011.05.004

Tomek, 2012, Role of Bcl-2 in tumour cell survival and implications for pharmacotherapy, J Pharm Pharmacol, 64, 1695, 10.1111/j.2042-7158.2012.01526.x

Zakeri, 2008, Cell death: history and future, Adv Exp Med Biol, 615, 1, 10.1007/978-1-4020-6554-5_1

Cheng, 2007, MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy?, Am J Pathol, 170, 1831, 10.2353/ajpath.2007.061170

Qin, 2012, MicroRNA 21 inhibits left ventricular remodeling in the early phase of rat model with ischemia-reperfusion injury by suppressing cell apoptosis, Int J Med Sci, 9, 413, 10.7150/ijms.4514

Sayed, 2010, MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand, J Biol Chem, 285, 20281, 10.1074/jbc.M110.109207

Cheng, 2009, MicroRNA-21 protects against the H(2)O(2)-induced injury on cardiac myocytes via its target gene PDCD4, J Mol Cell Cardiol, 47, 5, 10.1016/j.yjmcc.2009.01.008

Liu, 2012, PTEN and PDCD4 are bona fide targets of microRNA-21 in human cholangiocarcinoma, Chin Med Sci J, 27, 65

Meng, 2007, MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer, Gastroenterology, 133, 647, 10.1053/j.gastro.2007.05.022

McCubrey, 2012, Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance, Oncotarget, 3, 1068, 10.18632/oncotarget.659

Tang, 2013, MicroRNA-21 protects cardiomyocytes from tumor necrosis factor-alpha induced apoptosis in vitro via modulating PTEN/AKT/FOXO3a pathway, Chinese Journal of Cardiovascular Diseases, 41, 135

Ma, 2013, CGRP inhibits norepinephrine induced apoptosis with restoration of Bcl-2/Bax in cultured cardiomyocytes of rat, Neurosci Lett, 549, 130, 10.1016/j.neulet.2013.05.028

Xu, 2013, Three-dimensional structure of Bax-mediated pores in membrane bilayers, Cell Death Dis, 4, e683, 10.1038/cddis.2013.210

Walensky, 2011, BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore, Trends Biochem Sci, 36, 642, 10.1016/j.tibs.2011.08.009

Renault, 2011, Bax: Addressed to kill, Biochimie, 93, 1379, 10.1016/j.biochi.2011.05.013

Fiandalo, 2012, Caspase control: protagonists of cancer cell apoptosis, Exp Oncol, 34, 165

Snigdha, 2012, Caspase-3 activation as a bifurcation point between plasticity and cell death, Neurosci Bull, 28, 14, 10.1007/s12264-012-1057-5

Poreba, 2013, Caspase substrates and inhibitors, Cold Spring Harb Perspect Biol, 5, a008680, 10.1101/cshperspect.a008680

Kale, 2012, Shedding light on apoptosis at subcellular membranes, Cell, 151, 1179, 10.1016/j.cell.2012.11.013