miR-101 inhibits autophagy and enhances cisplatin-induced apoptosis in hepatocellular carcinoma cells

Oncology Reports - Tập 29 Số 5 - Trang 2019-2024 - 2013
Yong-hua Xu1, Yong An1, Yun Wang1, Changhe Zhang1, Zhang Hai1, Changjun Huang1, Hao Jiang1, Xuehao Wang1, Xiangcheng Li1
1Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Liver Transplantation, Ministry of Public Health, Nanjing, Jiangsu 210029, P.R. China

Tóm tắt

Từ khóa


Tài liệu tham khảo

El-Serag, 2007, Hepatocellular carcinoma: epidemiology and molecular carcinogenesis, Gastroenterology, 132, 2557, 10.1053/j.gastro.2007.04.061

Ashford, 1962, Cytoplasmic components in hepatic cell lysosomes, J Cell Biol, 12, 198, 10.1083/jcb.12.1.198

Mizushima, 2008, Autophagy fights disease through cellular self-digestion, Nature, 451, 1069, 10.1038/nature06639

Levine, 2008, Autophagy in the pathogenesis of disease, Cell, 132, 27, 10.1016/j.cell.2007.12.018

Mathew, 2007, Role of autophagy in cancer, Nat Rev Cancer, 7, 961, 10.1038/nrc2254

Yang, 2011, The role of autophagy in cancer: therapeutic implications, Mol Cancer Ther, 10, 1533, 10.1158/1535-7163.MCT-11-0047

Eskelinen, 2011, The dual role of autophagy in cancer, Curr Opin Pharmacol, 11, 294, 10.1016/j.coph.2011.03.009

Li, 2012, Interferon-gamma induces autophagy with growth inhibition and cell death in human hepatocellular carcinoma (HCC) cells through interferon-regulatory factor-1 (IRF-1), Cancer Lett, 314, 213, 10.1016/j.canlet.2011.09.031

Ding, 2008, Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma, Cancer Res, 68, 9167, 10.1158/0008-5472.CAN-08-1573

Ko, 2009, Autophagy inhibition enhances apoptosis induced by ginsenoside Rk1 in hepatocellular carcinoma cells, Biosci Biotechnol Biochem, 73, 2183, 10.1271/bbb.90250

Ganapathy-Kanniappan, 2010, 3-Bromopyruvate induces endoplasmic reticulum stress, overcomes autophagy and causes apoptosis in human HCC cell lines, Anticancer Res, 30, 923

Chen, 2011, Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative and involves the ATM signaling pathway, Biochem Pharmacol, 81, 594, 10.1016/j.bcp.2010.12.011

Xie, 2011, Autophagy inhibition enhances etoposide-induced cell death in human hepatoma G2 cells, Int J Mol Med, 27, 599

Kiyono, 2009, Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells, Cancer Res, 69, 8844, 10.1158/0008-5472.CAN-08-4401

Frankel, 2011, microRNA-101 is a potent inhibitor of autophagy, EMBO J, 30, 4628, 10.1038/emboj.2011.331

Ravikumar, 2008, Rab5 modulates aggregation and toxicity of mutant huntingtin through macroautophagy in cell and fly models of Huntington disease, J Cell Sci, 121, 1649, 10.1242/jcs.025726

Jung, 2010, mTOR regulation of autophagy, FEBS Lett, 584, 1287, 10.1016/j.febslet.2010.01.017

Chang, 2012, miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions, Gastroenterology, 143, 177, 10.1053/j.gastro.2012.04.009

Xu, 2012, Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell, Biochem Biophys Res Commun, 423, 826, 10.1016/j.bbrc.2012.06.048

Su, 2009, MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity, Cancer Res, 69, 1135, 10.1158/0008-5472.CAN-08-2886

Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and 2(−Delta Delta C(T)) Method, Methods, 25, 402, 10.1006/meth.2001.1262

Varambally, 2008, Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer, Science, 322, 1695, 10.1126/science.1165395

Chiang, 2010, PKCalpha mediated induction of miR-101 in human hepatoma HepG2 cells, J Biomed Sci, 17, 35, 10.1186/1423-0127-17-35

Buechner, 2011, Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma, Br J Cancer, 105, 296, 10.1038/bjc.2011.220

Wang, 2010, MicroRNA-101 is down-regulated in gastric cancer and involved in cell migration and invasion, Eur J Cancer, 46, 2295, 10.1016/j.ejca.2010.05.012

Gui, 2012, miRNA-101: A potential target for tumor therapy, Cancer Epidemiol, 36, 537, 10.1016/j.canep.2012.05.004