mTOR pathway inhibition prevents neuroinflammation and neuronal death in a mouse model of cerebral palsy

Neurobiology of Disease - Tập 85 - Trang 144-154 - 2016
Isha N. Srivastava1, Jona Shperdheja1, Marianna Baybis1, Tanya Ferguson1, Peter B. Crino1
1Shriners Hospitals Pediatric Research Center, Temple University School of Medicine, Philadelphia, PA 19140, United States

Tài liệu tham khảo

Allan, 2001, Cytokines and acute neurodegeneration, Nat. Rev. Neurosci., 2, 734, 10.1038/35094583 Auer, 1989, Neurobehavioral deficit due to ischemic brain damage limited to half of the CA1 sector of the hippocampus, J. Neurosci., 9, 1641, 10.1523/JNEUROSCI.09-05-01641.1989 Bax, 2005, Proposed definition and classification of cerebral palsy, April 2005, Dev. Med. Child Neurol., 47, 571, 10.1017/S001216220500112X Bax, 2006, Clinical and MRI correlates of cerebral palsy: the European Cerebral Palsy Study, JAMA, 296, 1602, 10.1001/jama.296.13.1602 Buckley, 2014, Rapamycin up-regulation of autophagy reduces infarct size and improves outcomes in both permanent MCAL, and embolic MCAO, murine models of stroke, Exp. Transl. Stroke Med., 6, 8, 10.1186/2040-7378-6-8 Carloni, 2008, Protective role of autophagy in neonatal hypoxia–ischemia induced brain injury, Neurobiol. Dis., 32, 329, 10.1016/j.nbd.2008.07.022 Carloni, 2010, Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia–ischemia, Autophagy, 6, 366, 10.4161/auto.6.3.11261 Chen, 2012, mTOR activates hypoxia-inducible factor-1α and inhibits neuronal apoptosis in the developing rat brain during the early phase after hypoxia–ischemia, Neurosci. Lett., 507, 118, 10.1016/j.neulet.2011.11.058 Chen, 2009, HIF-1 Alpha Inhibition Ameliorates Neonatal Brain Damage After Hypoxic–Ischemic Injury, 395 Curatolo, 2001, Infantile spasms in tuberous sclerosis complex, Brain Dev., 23, 502, 10.1016/S0387-7604(01)00300-X Czeh, 2011, The yin and yang of microglia, Dev. Neurosci., 33, 199, 10.1159/000328989 Deguchi, 1996, Immunohistochemical expression of tumor necrosis factor alpha in neonatal leukomalacia, Pediatr. Neurol., 14, 13, 10.1016/0887-8994(95)00223-5 Delaporte, 1985, Early echographic findings in non-hemorrhagic periventricular leukomalacia of the premature infant, Pediatr. Radiol., 15, 82, 10.1007/BF02388707 Di, 2012, S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt, Biochem. J., 441, 199, 10.1042/BJ20110033 Eklind, 2004, The role of glucose in brain injury following the combination of lipopolysaccharide or lipoteichoic acid and hypoxia–ischemia in neonatal rats, Dev. Neurosci., 26, 61, 10.1159/000080713 Fleiss, 2012, Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy?, Lancet Neurol., 11, 556, 10.1016/S1474-4422(12)70058-3 Fujioka, 2000, Hippocampal damage in the human brain after cardiac arrest, Cerebrovasc. Dis., 10, 2, 10.1159/000016018 Girard, 2009, Developmental motor deficits induced by combined fetal exposure to lipopolysaccharide and early neonatal hypoxia/ischemia: a novel animal model for cerebral palsy in very premature infants, Neuroscience, 158, 673, 10.1016/j.neuroscience.2008.10.032 Goorden, 2007, Cognitive deficits in Tsc1+/−mice in the absence of cerebral lesions and seizures, Ann. Neurol., 62, 648, 10.1002/ana.21317 Graham, 2004, Neonatal cerebral white matter injury in preterm infants is associated with culture positive infections and only rarely with metabolic acidosis, Am. J. Obstet. Gynecol., 191, 1305, 10.1016/j.ajog.2004.06.058 Hall, 2008, mTOR—What Does It Do?, Transplant. Proc., 40, S5, 10.1016/j.transproceed.2008.10.009 Horn, 1992, Delayed neuronal death and delayed neuronal recovery in the human brain following global ischemia, Acta Neuropathol. (Berl.), 85, 79, 10.1007/BF00304636 Hosokawa, 2009, Nutrient-dependent mTORC1 association with the ULK1–Atg13–FIP200 complex required for autophagy, Mol. Biol. Cell, 20, 1981, 10.1091/mbc.E08-12-1248 Hu, 2013, A rat pup model of cerebral palsy induced by prenatal inflammation and hypoxia, Neural Regen. Res., 8 Hudson, 2002, Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin, Mol. Cell. Biol., 22, 7004, 10.1128/MCB.22.20.7004-7014.2002 Jaakkola, 2001, Targeting of HIF-α to the von Hippel–Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation, Science, 292, 468, 10.1126/science.1059796 Jung, 2009, ULK-Atg13-FIP200 complexes mediate mTOR Signaling to the autophagy machinery, Mol. Biol. Cell, 20, 1992, 10.1091/mbc.E08-12-1249 Kadhim, 2001, Inflammatory cytokines in the pathogenesis of periventricular leukomalacia, Neurology, 56, 1278, 10.1212/WNL.56.10.1278 Kaur, 2009, Periventricular white matter damage in the hypoxic neonatal brain: role of microglial cells, Prog. Neurobiol., 87, 264, 10.1016/j.pneurobio.2009.01.003 Keogh, 2006, The origins of cerebral palsy, Curr. Opin. Neurol., 19, 129, 10.1097/01.wco.0000218227.35560.0d Kiffin, 2006, Oxidative stress and autophagy, Antioxid. Redox Signal., 8, 152, 10.1089/ars.2006.8.152 Kirby, 2011, Prevalence and functioning of children with cerebral palsy in four areas of the United States in 2006: a report from the autism and developmental disabilities monitoring network, Res. Dev. Disabil., 32, 462, 10.1016/j.ridd.2010.12.042 Krägeloh-Mann, 2007, The role of magnetic resonance imaging in elucidating the pathogenesis of cerebral palsy: a systematic review, Dev. Med. Child Neurol., 49, 144, 10.1111/j.1469-8749.2007.00144.x Krägeloh-Mann, 2002, Bilateral lesions of thalamus and basal ganglia: origin and outcome, Dev. Med. Child Neurol., 44, 477, 10.1111/j.1469-8749.2002.tb00309.x Kusaba, 2005, Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR), J. Biol. Chem., 280, 1037, 10.1074/jbc.M405204200 Lein, 2007, Genome-wide atlas of gene expression in the adult mouse brain, Nature, 445, 168, 10.1038/nature05453 Levine, 2004, Development by self-digestion: molecular mechanisms and biological functions of autophagy, Dev. Cell, 6, 463, 10.1016/S1534-5807(04)00099-1 Maxwell, 1999, The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis, Nature, 399, 271, 10.1038/20459 Nelson, 1998, Potentially asphyxiating conditions and spastic cerebral palsy in infants of normal birth weight, Am. J. Obstet. Gynecol., 179, 507, 10.1016/S0002-9378(98)70387-4 Ng, 2011, Impaired autophagy due to constitutive mTOR activation sensitizes TSC2-null cells to cell death under stress, Autophagy, 7, 1173, 10.4161/auto.7.10.16681 Pakula, 2009, Cerebral palsy: classification and epidemiology, Phys. Med. Rehabil. Clin. N. Am., 20, 425, 10.1016/j.pmr.2009.06.001 Papadakis, 2013, Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy, Nat. Med., 19, 351, 10.1038/nm.3097 Pearce, 2010, Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1), Biochem. J., 431, 245, 10.1042/BJ20101024 Rami, 2003, Spatial resolution of phospholipid scramblase 1 (PLSCR1), caspase-3 activation and DNA-fragmentation in the human hippocampus after cerebral ischemia, Neurochem. Int., 43, 79, 10.1016/S0197-0186(02)00194-8 Rees, 2005, Fetal and neonatal origins of altered brain development, Early Hum. Dev., 81, 753, 10.1016/j.earlhumdev.2005.07.004 Russo, 2009, Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation, Biochem. Pharmacol., 78, 1242, 10.1016/j.bcp.2009.06.097 Schmidt-Kastner, 1991, Selective vulnerability of the hippocampus in brain ischemia, Neuroscience, 40, 599, 10.1016/0306-4522(91)90001-5 Sharma, 2010, Dysregulation of mTOR signaling in Fragile X syndrome, J. Neurosci., 30, 694, 10.1523/JNEUROSCI.3696-09.2010 Sheldon, 2014, Hypoxic preconditioning protection is eliminated in HIF-1α knockout mice subjected to neonatal hypoxia–ischemia, Pediatr. Res., 76, 46, 10.1038/pr.2014.53 Shen, 2012, Axon–glia synapses are highly vulnerable to white matter injury in the developing brain, J. Neurosci. Res., 90, 105, 10.1002/jnr.22722 Shen, 2010, Mouse models of periventricular leukomalacia, J. Vis. Exp. JoVE, 10.3791/1951 Sugawara, 2002, Effects of global ischemia duration on neuronal, astroglial, oligodendroglial, and microglial reactions in the vulnerable hippocampal CA1 subregion in rats, J. Neurotrauma, 19, 85, 10.1089/089771502753460268 Talos, 2012, The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway, PLoS One, 7, 10.1371/journal.pone.0035885 Tan, 2005, Model of cerebral palsy in the perinatal rabbit, J. Child Neurol., 20, 972, 10.1177/08830738050200120801 Weichhart, 2008, The TSC-mTOR signaling pathway regulates the innate inflammatory response, Immunity, 29, 565, 10.1016/j.immuni.2008.08.012 Wheater, 2000, Perinatal infection is an important risk factor for cerebral palsy in very-low-birthweight infants, Dev. Med. Child Neurol., 364, 10.1017/S0012162200000670 Wu, 2009, Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy, Autophagy, 5, 824, 10.4161/auto.9099 Zeng, 2008, Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex, Ann. Neurol., 63, 444, 10.1002/ana.21331 Zhong, 2000, Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics, Cancer Res., 60, 1541