l-Carnitine attenuates H2O2-induced neuron apoptosis via inhibition of endoplasmic reticulum stress

Neurochemistry International - Tập 78 - Trang 86-95 - 2014
Junli Ye1, Yantao Han2, Xuehong Chen2, Jing Xie2, Xiaojin Liu3, Shunhong Qiao4, Chunbo Wang2
1Department of Pathophysiology, Medical College, Qingdao University, Qingdao, Shandong 266071, China
2Department of Pharmacology, Medical College, Qingdao University, Qingdao 266071, China
3Department of Pharmacy, Dezhou People's Hospital, Dezhou, China
4Department of Biological Sciences, University of Memphis, TN 38111, USA

Tài liệu tham khảo

Ariazi, 2011, Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time, Proc. Natl. Acad. Sci. U.S.A., 108, 18879, 10.1073/pnas.1115188108 Binienda, 2001, Neuroprotective role of l-carnitine in the 3-nitropropionic acid induced neurotoxicity, Toxicol. Lett., 125, 67, 10.1016/S0378-4274(01)00415-5 Binienda, 2004, Neuroprotective effect of l-carnitine in the 3-nitropropionic acid (3-NPA)-evoked neurotoxicity in rats, Neurosci. Lett., 367, 264, 10.1016/j.neulet.2004.05.031 Calabrese, 2010, Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders, Antioxid. Redox Signal., 13, 1763, 10.1089/ars.2009.3074 Dhitavat, 2005, Folate, vitamin E, and acetyl-l-carnitine provide synergistic protection against oxidative stress resulting from exposure of human neuroblastoma cells to amyloid-beta, Brain Res., 1061, 114, 10.1016/j.brainres.2005.05.074 Ghosh, 2011, Antioxidant protection: a promising therapeutic intervention in neurodegenerative disease, Free Radical Res., 45, 888, 10.3109/10715762.2011.574290 Ghosh, 2012, CHOP potentially cooperates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress, PLoS One, 7, e39586, 10.1371/journal.pone.0039586 Gibson, 2004, Mitochondrial enzymes and endoplasmic reticulum calcium stores as targets of oxidative stress in neurodegenerative diseases, J. Bioenerg. Biomembr., 36, 335, 10.1023/B:JOBB.0000041764.45552.f3 Gülçin, 2006, Antioxidant and antiradical activities of l-carnitine, Life Sci., 78, 803, 10.1016/j.lfs.2005.05.103 Halliwell, 2006, Oxidative stress and neurodegeneration: where are we now?, J. Neurochem., 97, 1634, 10.1111/j.1471-4159.2006.03907.x Higgins, 2010, Oxidative stress: emerging mitochondrial and cellular themes and variations in neuronal injury, J. Alzheimers, 20, S453, 10.3233/JAD-2010-100321 Jiang, 2004, Lovastatin-induced up-regulation of the BH3-only protein, Bim, and cell death in glioblastoma cells, J. Neurochem., 89, 168, 10.1111/j.1471-4159.2004.02319.x Kanekura, 2009, ER stress and unfolded protein response in amyotrophic lateral sclerosis, Mol. Neurobiol., 39, 81, 10.1007/s12035-009-8054-3 Kim, 2010, Pathological roles of MAPK signaling pathways in human diseases, Biochim. Biophys. Acta, 1802, 396, 10.1016/j.bbadis.2009.12.009 Le Bel, 1992, Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress, Chem. Res. Toxicol., 5, 227, 10.1021/tx00026a012 Liu, 2013, Signaling pathways involved in endoplasmic reticulum stress-induced neuronal apoptosis, Int. J. Neurosci., 123, 155, 10.3109/00207454.2012.746974 Logue, 2013, New directions in ER stress-induced cell death, Apoptosis, 18, 537, 10.1007/s10495-013-0818-6 Malhotra, 2007, Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?, Antioxid. Redox Signal., 9, 2277, 10.1089/ars.2007.1782 Mazzio, 2003, Acetyl-l-carnitine cytoprotection against 1-methyl-4-phenylpyridinium toxicity in neuroblastoma cells, Biochem. Pharmacol., 66, 297, 10.1016/S0006-2952(03)00261-2 McCullough, 2001, Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl-2 and perturbing the cellular redox state, Mol. Cell. Biol., 21, 1249, 10.1128/MCB.21.4.1249-1259.2001 Nalecz, 1996, Carnitine-a known compound, a novel function in neural cells, Acta Neurobiol. Exp., 56, 597 Oyadomari, 2004, Roles of CHOP/GADD153 in endoplasmic reticulum stress, Cell Death Differ., 11, 381, 10.1038/sj.cdd.4401373 Puthalakath, 2007, ER stress triggers apoptosis by activating BH3-only protein Bim, Cell, 129, 1337, 10.1016/j.cell.2007.04.027 Rani, 2001, Carnitine as a free radical scavenger in aging, Exp. Gerontol., 36, 1713, 10.1016/S0531-5565(01)00116-4 Runchel, 2011, Mitogen-activated protein kinases in mammalian oxidative stress responses, Antioxid. Redox Signal., 15, 205, 10.1089/ars.2010.3733 Scheper, 2009, Endoplasmic reticulum protein quality control in neurodegenerative disease: the good, the bad and the therapy, Curr. Med. Chem., 16, 615, 10.2174/092986709787458506 Scott, 2008, Upregulation of GADD153 by butyrate: involvement of MAPK, DNA Cell Biol., 27, 607, 10.1089/dna.2008.0773 Stefani, 2012, The role of ER stress-induced apoptosis in neurodegeneration, Curr. Alzheimer Res., 9, 373, 10.2174/156720512800107618 Vela, 2013, Direct interaction of Bax and Bak proteins with Bcl-2 homology domain 3 (BH3)-only proteins in living cells revealed by fluorescence complementation, J. Biol. Chem., 288, 4935, 10.1074/jbc.M112.422204 Virmani, 2004, Role of carnitine esters in brain neuropathology, Mol. Aspects Med., 25, 533, 10.1016/j.mam.2004.06.003 Ye, 2009, Cytoprotective effect of polypeptide from Chlamys farreri on neuroblastoma (SH-SY5Y) cells following HO exposure involves scavenging ROS and inhibition JNK phosphorylation, J. Neurochem., 111, 441, 10.1111/j.1471-4159.2009.06328.x Yu, 2011, Protective effect of l-carnitine against H(2)O(2)-induced neurotoxicity in neuroblastoma (SH-SY5Y) cells, Neurol. Res., 33, 708, 10.1179/1743132810Y.0000000028