hnRNP H1 and intronic G runs in the splicing control of the human rpL3 gene

Annapina Russo1,2, Gabriella Siciliano1, Morena Catillo1, Chiara Giangrande3, Angela Amoresano3, Pietro Pucci3,2, Concetta Pietropaolo1, Giulia Russo1
1Dipartimento di Biochimica e Biotecnologie Mediche, Università Federico II, Via Sergio Pansini 5, Napoli 80131, Italy
2CEINGE Biotecnologie Avanzate S.C.a.r.l., Via Comunale Margherita 482, Napoli 80145, Italy
3Dipartimento di Chimica Organica e Biologica, Università Federico II, Complesso Universitario Monte S. Angelo, Via Cinthia 4, Napoli 80126, Italy

Tài liệu tham khảo

Modrek, 2001, Genome-wide detection of alternative splicing in expressed sequences of human genes, Nucleic Acids Res., 29, 2850, 10.1093/nar/29.13.2850 Black, 2003, Mechanisms of alternative pre-messenger RNA splicing, Annu. Rev. Biochem., 72, 291, 10.1146/annurev.biochem.72.121801.161720 Lim, 1998, Alternative splicing of the fibronectin EIIIB exon depends on specific TGCATG repeats, Mol. Cell. Biol., 18, 3900, 10.1128/MCB.18.7.3900 Chan, 1997, Conserved intron elements repress splicing of a neuron-specific c-src exon in vitro, Mol. Cell. Biol., 17, 2970, 10.1128/MCB.17.5.2970 Modafferi, 1997, A complex intronic splicing enhancer from the c-src pre-mRNA activates inclusion of a heterologous exon, Mol. Cell. Biol., 17, 6537, 10.1128/MCB.17.11.6537 Han, 2005, A combinatorial code for splicing silencing: UAGG and GGGG motifs, PLoS Biol., 3, e158, 10.1371/journal.pbio.0030158 McCullough, 1997, G triplets located throughout a class of small vertebrate introns enforce intron borders and regulate splice site selection, Mol. Cell. Biol., 17, 4562, 10.1128/MCB.17.8.4562 McCarthy, 1998, Characterization of an intron splice enhancer that regulates alternative splicing of human GH pre-mRNA, Hum. Mol. Genet., 7, 1491, 10.1093/hmg/7.9.1491 Caputi, 2001, Determination of the RNA binding specificity of the heterogeneous nuclear ribonucleoprotein (hnRNP) H/H′/F/2H9 family, J. Biol. Chem., 276, 43850, 10.1074/jbc.M102861200 Schaub, 2007, Members of the heterogeneous nuclear ribonucleoprotein H family activate splicing of an HIV-1 splicing substrate by promoting formation of ATP-dependent spliceosomal complexes, J. Biol. Chem., 282, 13617, 10.1074/jbc.M700774200 Marcucci, 2007, Complex splicing control of the human Thrombopoietin gene by intronic G runs, Nucleic Acids Res., 35, 132, 10.1093/nar/gkl965 McCullough, 2000, An intronic splicing enhancer binds U1 snRNPs to enhance splicing and select 5′ splice sites, Mol. Cell. Biol., 20, 9225, 10.1128/MCB.20.24.9225-9235.2000 Chen, 1999, Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat beta-tropomyosin gene, Genes Dev., 13, 593, 10.1101/gad.13.5.593 Caputi, 2002, SR proteins and hnRNP H regulate the splicing of the HIV-1 tev-specific exon 6D, Embo J., 21, 845, 10.1093/emboj/21.4.845 Expert-Bezancon, 2004, hnRNP A1 and the SR proteins ASF/SF2 and SC35 have antagonistic functions in splicing of beta-tropomyosin exon 6B, J. Biol. Chem., 279, 38249, 10.1074/jbc.M405377200 Krecic, 1999, hnRNP complexes: composition, structure, and function, Curr. Opin. Cell Biol., 11, 363, 10.1016/S0955-0674(99)80051-9 Martinez-Contreras, 2007, hnRNP proteins and splicing control, Adv. Exp. Med. Biol., 623, 123, 10.1007/978-0-387-77374-2_8 Masuda, 2008, hnRNP H enhances skipping of a nonfunctional exon P3A in CHRNA1 and a mutation disrupting its binding causes congenital myasthenic syndrome, Hum. Mol. Genet., 17, 4022, 10.1093/hmg/ddn305 Chang, 2007, The nonsense-mediated decay RNA surveillance pathway, Annu. Rev. Biochem., 76, 51, 10.1146/annurev.biochem.76.050106.093909 McGlincy, 2008, Alternative splicing resulting in nonsense-mediated mRNA decay: what is the meaning of nonsense?, Trends Biochem. Sci., 33, 385, 10.1016/j.tibs.2008.06.001 Mitrovich, 2000, Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C. elegans, Genes Dev., 14, 2173, 10.1101/gad.819900 Cuccurese, 2005, Alternative splicing and nonsense-mediated mRNA decay regulate mammalian ribosomal gene expression, Nucleic Acids Res., 33, 5965, 10.1093/nar/gki905 Zito, 2007, Sulfatase modifying factor 1 trafficking through the cells: from endoplasmic reticulum to the endoplasmic reticulum, Embo J., 26, 2443, 10.1038/sj.emboj.7601695 Loreni, 1993, Coordinate translational regulation in the syntheses of elongation factor 1 alpha and ribosomal proteins in Xenopus laevis, Nucleic Acids Res., 21, 4721, 10.1093/nar/21.20.4721 Friedman, 1981, Evidence that ribosomal protein S10 participates in control of transcription termination, Proc. Natl. Acad. Sci. U. S. A., 78, 1115, 10.1073/pnas.78.2.1115 Luo, 2008, Structural and functional analysis of the E. coli NusB-S10 transcription antitermination complex, Mol. Cell, 32, 791, 10.1016/j.molcel.2008.10.028 Singh, 2009, Regulation of ribonuclease E activity by the L4 ribosomal protein of Escherichia coli, Proc. Natl. Acad. Sci. U. S. A., 106, 864, 10.1073/pnas.0810205106 Wang, 2007, Human mitochondrial ribosomal protein MRPL12 interacts directly with mitochondrial RNA polymerase to modulate mitochondrial gene expression, J. Biol. Chem., 282, 12610, 10.1074/jbc.M700461200 Chaudhuri, 2007, Human ribosomal protein L13a is dispensable for canonical ribosome function but indispensable for efficient rRNA methylation, Rna, 13, 2224, 10.1261/rna.694007 Dabeva, 1993, Ribosomal protein L32 of Saccharomyces cerevisiae regulates both splicing and translation of its own transcript, J. Biol. Chem., 268, 19669, 10.1016/S0021-9258(19)36568-8 Ivanov, 2005, Human ribosomal protein S26 suppresses the splicing of its pre-mRNA, Biochim. Biophys. Acta, 1727, 134, 10.1016/j.bbaexp.2004.12.011 Malygin, 2007, Human ribosomal protein S13 regulates expression of its own gene at the splicing step by a feedback mechanism, Nucleic Acids Res., 35, 6414, 10.1093/nar/gkm701 Wang, 2008, Splicing regulation: from a parts list of regulatory elements to an integrated splicing code, RNA, 14, 802, 10.1261/rna.876308 Mauger, 2008, hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc, Mol. Cell. Biol., 28, 5403, 10.1128/MCB.00739-08