circRNA of AR‑suppressed PABPC1 91�bp enhances the cytotoxicity of natural killer cells against hepatocellular carcinoma via upregulating UL16 binding protein 1

Torre, 2015, Global cancer statistics, 2012, CA Cancer J Clin, 65, 87, 10.3322/caac.21262

Park, 2015, Global patterns of hepatocellular carcinoma management from diagnosis to death: The BRIDGE Study, Liver Int, 35, 2155, 10.1111/liv.12818

Mohammed, 2018, Socio-economic deprivation significantly impacts clinical management and survival in hepatocellular carcinoma, J Hepatol, 68, 623, 10.1016/j.jhep.2017.09.031

Mancuso, 2018, Management of hepatocellular carcinoma recurrence after liver transplant is far from perfect, Am J Surg, 216, 389, 10.1016/j.amjsurg.2017.04.004

2012, European Association For The Study Of The Liver; European Organisation For Research And Treatment Of Cancer: EASL-EORTC clinical practice guidelines: Management of hepatocellular carcinoma, J Hepatol, 56, 908, 10.1016/j.jhep.2011.12.001

Bruix, 2012, Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: Subanalyses of a phase III trial, J Hepatol, 57, 821, 10.1016/j.jhep.2012.06.014

Parikh, 2017, Survival and cost-effectiveness of sorafenib therapy in advanced hepatocellular carcinoma: An analysis of the SEER-Medicare database, Hepatology, 65, 122, 10.1002/hep.28881

Fu, 2018, Precision diagnosis and treatment of liver cancer in China, Cancer Lett, 412, 283, 10.1016/j.canlet.2017.10.008

Sia, 2017, Liver cancer cell of origin, molecular class, and effects on patient prognosis, Gastroenterology, 152, 745, 10.1053/j.gastro.2016.11.048

Hansen, 2013, Natural RNA circles function as efficient microRNA sponges, Nature, 495, 384, 10.1038/nature11993

Dou, 2016, Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes, Sci Rep, 6, 37982, 10.1038/srep37982

Du, 2017, Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity, Cell death and differ, 357, 10.1038/cdd.2016.133

Chen, 2017, Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer, Cancer Lett, 388, 208, 10.1016/j.canlet.2016.12.006

Qin, 2016, Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma, Cancer Biomark, 16, 161, 10.3233/CBM-150552

Ma, 2014, Androgen receptor roles in hepatocellular carcinoma, fatty liver, cirrhosis and hepatitis, Endocr Relat Cancer, 21, R165, 10.1530/ERC-13-0283

Shi, 2017, Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma, Cell Death Dis, 8, e3171, 10.1038/cddis.2017.556

Soriani, 2009, ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype, Blood, 113, 3503, 10.1182/blood-2008-08-173914

Shi, 2016, Targeting androgen receptor (AR)→IL12A signal enhances efficacy of sorafenib plus NK cells immunotherapy to better suppress HCC progression, Mol Cancer Ther, 15, 731, 10.1158/1535-7163.MCT-15-0706

Ding, 2015, MRC-5 fibroblast-conditioned medium influences multiple pathways regulating invasion, migration, proliferation, and apoptosis in hepatocellular carcinoma, J Transl Med, 13, 237, 10.1186/s12967-015-0588-8

Krzywinska, 2017, Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis, Nat Commun, 8, 1597, 10.1038/s41467-017-01599-w

Wu, 2013, Monocyte/macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions, Hepatology, 57, 1107, 10.1002/hep.26192

Shi, 2016, Cisplatin enhances NK cells immunotherapy efficacy to suppress HCC progression via altering the androgen receptor (AR)-ULBP2 signals, Cancer Lett, 373, 45, 10.1016/j.canlet.2016.01.017

Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method, Methods, 25, 402, 10.1006/meth.2001.1262

Cho, 2011, Potential candidate biomarkers for heterogeneity in triple-negative breast cancer (TNBC), Cancer Chemother Pharmacol, 68, 753, 10.1007/s00280-010-1548-x

Törnqvist, 2014, Strategic focus on 3R principles reveals major reductions in the use of animals in pharmaceutical toxicity testing, PLoS One, 9, e101638, 10.1371/journal.pone.0101638

Zheng, 2016, Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs, Nat Commun, 7, 11215, 10.1038/ncomms11215

Guo, 2014, Expanded identification and characterization of mammalian circular RNAs, Genome Biol, 15, 409, 10.1186/s13059-014-0409-z

You, 2015, Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity, Nat Neurosci, 18, 603, 10.1038/nn.3975

Haque, 2017, Circular RNAs (circRNAs) in health and disease, Genes (Basel), 8, E353, 10.3390/genes8120353

Abdelmohsen, 2017, Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1, RNA Biol, 14, 361, 10.1080/15476286.2017.1279788

Conn, 2017, A circRNA from SEPALLATA3 regulates splicing of its cognate mRNA through R-loop formation, Nat Plants, 3, 17053, 10.1038/nplants.2017.53

Li, 2015, Exon-intron circular RNAs regulate transcription in the nucleus, Nat Struct Mol Biol, 22, 256, 10.1038/nsmb.2959

Huergo-Zapico, 2014, Molecular bases for the regulation of NKG2D ligands in cancer, Front Immunol, 5, 106, 10.3389/fimmu.2014.00106

Shin, 2017, Trichostatin A sensitizes hepatocellular carcinoma cells to enhanced NK cell-mediated killing by regulating immune-related genes, Cancer Genomics Proteomics, 14, 349

Xu, 2017, The anti-hepatocellular carcinoma activity of Mel-P15 is mediated by natural killer cells, Oncol Lett, 14, 6901

Zhu, 2017, Natural killer cell (NK-92MI)-based therapy for pulmonary metastasis of anaplastic thyroid cancer in a nude mouse model, Front Immunol, 8, 816, 10.3389/fimmu.2017.00816