c-fms blockade reverses glomerular macrophage infiltration and halts development of crescentic anti-GBM glomerulonephritis in the rat

Kerr, 2007, Rapidly progressive glomerulonephritis, 1511 Little, 2005, Glomerulonephritis due to antineutrophil cytoplasm antibody-associated vasculitis: an update on approaches to management, Nephrology (Carlton), 10, 368, 10.1111/j.1440-1797.2005.00434.x Holdsworth, 1981, Abrogation of macrophage-dependent injury in experimental glomerulonephritis in the rabbit. Use of an antimacrophage serum, J Clin Invest, 68, 686, 10.1172/JCI110304 Ikezumi, 2003, Adoptive transfer studies demonstrate that macrophages can induce proteinuria and mesangial cell proliferation, Kidney Int, 63, 83, 10.1046/j.1523-1755.2003.00717.x Isome, 2004, Important role for macrophages in induction of crescentic anti-GBM glomerulonephritis in WKY rats, Nephrol Dial Transplant, 19, 2997, 10.1093/ndt/gfh558 Lenda, 2004, Negative role of colony-stimulating factor-1 in macrophage, T cell, and B cell mediated autoimmune disease in MRL-Fas(lpr) mice, J Immunol, 173, 4744, 10.4049/jimmunol.173.7.4744 Duffield, 2005, Conditional ablation of macrophages halts progression of crescentic glomerulonephritis, Am J Pathol, 167, 1207, 10.1016/S0002-9440(10)61209-6 Pixley, 2004, CSF-1 regulation of the wandering macrophage: complexity in action, Trends Cell Biol, 14, 628, 10.1016/j.tcb.2004.09.016 Isbel, 2001, Local macrophage proliferation correlates with increased renal M-CSF expression in human glomerulonephritis, Nephrol Dial Transplant, 16, 1638, 10.1093/ndt/16.8.1638 Isbel, 2001, Tubules are the major site of M-CSF production in experimental kidney disease: correlation with local macrophage proliferation, Kidney Int, 60, 614, 10.1046/j.1523-1755.2001.060002614.x Menke, 2009, Circulating CSF-1 promotes monocyte and macrophage phenotypes that enhance lupus nephritis, J Am Soc Nephrol, 20, 2581, 10.1681/ASN.2009050499 Ma, 2009, Targeting renal macrophage accumulation via c-fms kinase reduces tubular apoptosis but fails to modify progressive fibrosis in the obstructed rat kidney, Am J Physiol Renal Physiol, 296, F177, 10.1152/ajprenal.90498.2008 Ma, 2009, Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat, Lab Invest, 89, 470, 10.1038/labinvest.2009.2 Lan, 1995, Local macrophage proliferation in the progression of glomerular and tubulointerstitial injury in rat anti-GBM glomerulonephritis, Kidney Int, 48, 753, 10.1038/ki.1995.347 Heymann, 2009, Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury, J Clin Invest, 119, 1286, 10.1172/JCI38399 Wang, 1988, Induction of monocyte migration by recombinant macrophage colony-stimulating factor, J Immunol, 141, 575, 10.4049/jimmunol.141.2.575 Kluth, 2001, Macrophages transfected with adenovirus to express IL-4 reduce inflammation in experimental glomerulonephritis, J Immunol, 166, 4728, 10.4049/jimmunol.166.7.4728 Dai, 2002, Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects, Blood, 99, 111, 10.1182/blood.V99.1.111 Behmoaras, 2008, Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility, Nat Genet, 40, 553, 10.1038/ng.137 D'Agati, 2008, Podocyte injury in focal segmental glomerulosclerosis: lessons from animal models (a play in five acts), Kidney Int, 73, 399, 10.1038/sj.ki.5002655 Le Hir, 2001, Podocyte bridges between the tuft and Bowman's capsule: an early event in experimental crescentic glomerulonephritis, J Am Soc Nephrol, 12, 2060, 10.1681/ASN.V12102060 Moeller, 2004, Podocytes populate cellular crescents in a murine model of inflammatory glomerulonephritis, J Am Soc Nephrol, 15, 61, 10.1097/01.ASN.0000102468.37809.C6 Ikezumi, 2003, Interferon-gamma augments acute macrophage-mediated renal injury via a glucocorticoid-sensitive mechanism, J Am Soc Nephrol, 14, 888, 10.1097/01.ASN.0000056604.13964.62 Ikezumi, 2004, Macrophage-mediated renal injury is dependent on signaling via the JNK pathway, J Am Soc Nephrol, 15, 1775, 10.1097/01.ASN.0000131272.06958.DE Zoja, 2009, The role of chemokines in progressive renal disease, Front Biosci, 14, 1815, 10.2741/3343 Yu, 1999, IL-1 up-regulates osteopontin expression in experimental crescentic glomerulonephritis in the rat, Am J Pathol, 154, 833, 10.1016/S0002-9440(10)65330-8 Scholz, 2008, Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis, J Am Soc Nephrol, 19, 527, 10.1681/ASN.2007060684 Rogers, 2009, Review article: kidney dendritic cells: their role in homeostasis, inflammation and transplantation, Nephrology (Carlton), 14, 625, 10.1111/j.1440-1797.2009.01200.x Sung, 2010, T cells and dendritic cells in glomerular disease: the new glomerulotubular feedback loop, Kidney Int, 77, 393, 10.1038/ki.2009.489 Leon, 2008, Monocyte-derived dendritic cells in innate and adaptive immunity, Immunol Cell Biol, 86, 320, 10.1038/icb.2008.14 Segura, 2009, Antigen presentation by dendritic cells in vivo, Curr Opin Immunol, 21, 105, 10.1016/j.coi.2009.03.011 Witmer-Pack, 1993, Identification of macrophages and dendritic cells in the osteopetrotic (op/op) mouse, J Cell Sci, 104, 1021, 10.1242/jcs.104.4.1021 Liu, 2009, In vivo analysis of dendritic cell development and homeostasis, Science, 324, 392, 10.1126/science.1170540 Ferenbach, 2008, Macrophages and dendritic cells: what is the difference?, Kidney Int, 74, 5, 10.1038/ki.2008.189