c-Src Regulates Constitutive and EGF-mediated VEGF Expression in Pancreatic Tumor Cells Through Activation of Phosphatidyl Inositol-3 Kinase and p38 MAPK

Korc, 2003, Pathways for aberrant angiogenesis in pancreatic cancer., Mol Cancer, 2, 1, 10.1186/1476-4598-2-8

Shi, 2001, Pancreatic cancer: factors regulating tumor development, maintenance and metastasis., Pancreatol, 1, 517, 10.1159/000055854

Keleg, 2003, Invasion and metastasis in pancreatic cancer., Mol Cancer, 2, 14, 10.1186/1476-4598-2-14

MacKenzie, 2004, Molecular therapy in pancreatic adenocarcinoma., Lancet Oncol, 5, 541, 10.1016/S1470-2045(04)01565-7

Lutz, 1998, Overexpression and activation of the tyrosine kinase Src in human pancreatic carcinoma., Biochem Biophys Res Commun, 243, 503, 10.1006/bbrc.1997.8043

Parsons, 2004, Src family kinases, key regulators of signal transduction., Oncogene, 23, 7906, 10.1038/sj.onc.1208160

Thomas, 1997, Cellular functions regulated by Src family kinases., Annu Rev Cell Dev Biol, 13, 513, 10.1146/annurev.cellbio.13.1.513

Martin, 2004, The road to Src., Oncogene, 23, 7910, 10.1038/sj.onc.1208077

Summy, 2003, Src family kinases in tumor progression and metastasis., Cancer Metastasis Rev, 22, 337, 10.1023/A:1023772912750

Gerwins, 2000, Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis., Crit Rev Oncol Hematol, 34, 185, 10.1016/S1040-8428(00)00062-7

Bockhorn, 2003, Differential vascular and transcriptional responses to anti-vascular endothelial growth factor antibody in orthotopic human pancreatic cancer xenografts., Clin Cancer Res, 9, 4221

Gannon, 2002, Overexpression of vascular endothelial growth factor-A165 enhances tumor angiogenesis but not metastasis during beta-cell carcinogenesis., Cancer Res, 62, 603

Hotz, 2002, Specific targeting of tumor vasculature by diphtheria toxin-vascular endothelial growth factor fusion protein reduces angiogenesis and growth of pancreatic cancer., J Gastrointest Surg, 6, 159, 10.1016/S1091-255X(01)00040-3

Hotz, 2003, Evaluation of vascular endothelial growth factor blockade and matrix metalloproteinase inhibition as a combination therapy for experimental human pancreatic cancer., J Gastrointest Surg, 7, 220, 10.1016/S1091-255X(02)00157-9

Inoue, 2002, VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis., Cancer Cell, 1, 193, 10.1016/S1535-6108(02)00031-4

Itakura, 2000, Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer., Int J Cancer, 85, 27, 10.1002/(SICI)1097-0215(20000101)85:1<27::AID-IJC5>3.0.CO;2-8

Seo, 2000, High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma., Cancer, 88, 2239, 10.1002/(SICI)1097-0142(20000515)88:10<2239::AID-CNCR6>3.0.CO;2-V

Tsuzuki, 2001, Pancreas microenvironment promotes VEGF expression and tumor growth: novel window models for pancreatic tumor angiogenesis and microcirculation., Lab Invest, 81, 1439, 10.1038/labinvest.3780357

Akagi, 2003, Induction of neuropilin-1 and vascular endothelial growth factor by epidermal growth factor in human gastric cancer cells., Br J Cancer, 88, 796, 10.1038/sj.bjc.6600811

Dong, 2001, C. Hepatocyte growth factor/scatter factor-induced activation of MEK and PI3K signal pathways contributes to expression of proangiogenic cytokines interleukin-8 and vascular endothelial growth factor in head and neck squamous cell carcinoma., Cancer Res, 61, 5911

Maity, 2000, Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3-kinase and distinct from that induced by hypoxia., Cancer Res, 60, 5879

Mazure, 2003, Protein kinases and the hypoxia-inducible factor-1, two switches in angiogenesis., Curr Pharm Des, 9, 531, 10.2174/1381612033391469

Zeng, 2003, Requirement of different signaling pathways mediated by insulin-like growth factor-I receptor for proliferation, invasion, and VPF/VEGF expression in a pancreatic carcinoma cell line., Biochem Biophys Res Commun, 302, 46, 10.1016/S0006-291X(03)00107-4

Jung, 2001, Vascular endothelial growth factor is upregulated by interleukin-1 beta in human vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway., Angiogenesis, 4, 155, 10.1023/A:1012291524723

Hu, 2003, Dual mechanisms for lysophosphatidic acid stimulation of human ovarian carcinoma cells., J Natl Cancer Inst, 95, 733, 10.1093/jnci/95.10.733

Hu, 2001, Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells., J Natl Cancer Inst, 93, 762, 10.1093/jnci/93.10.762

Choi, 2003, Hypoxia-induced angiogenesis during carcinogenesis., J Biochem Mol Biol, 36, 120

Shemirani, 2002, Hypoxic induction of HIF-1alpha and VEGF expression in head and neck squamous cell carcinoma lines is mediated by stress activated protein kinases., Oral Oncol, 38, 251, 10.1016/S1368-8375(01)00052-5

Xu, 2002, Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF., J Biol Chem, 277, 11368, 10.1074/jbc.M108347200

Oikawa, 1995, Frequent expression of genes for receptor tyrosine kinases and their ligands in human pancreatic cancer cells., Int J Pancreatol, 18, 15, 10.1007/BF02825417

Yamanaka, 1993, Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness., Anticancer Res, 13, 565

Poston, 1991, Biology of pancreatic cancer., Gut, 32, 800, 10.1136/gut.32.7.800

Baker, 2002, Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer., Cancer Res, 62, 1996

Bruns, 2000, Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma., Cancer Res, 60, 2926

Bruns, 2000, Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms., Clin Cancer Res, 6, 1936

Arteaga, 2002, Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia., Semin Oncol, 29, 3, 10.1053/sonc.2002.35642

Arteaga, 2002, Epidermal growth factor receptor dependence in human tumors: more than just expression?, Oncologist, 7, 31, 10.1634/theoncologist.7-suppl_4-31

Ciardiello, 2003, Epidermal growth factor receptor (EGFR) as a target in cancer therapy: understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs., Eur J Cancer, 39, 1348, 10.1016/S0959-8049(03)00235-1

Yezhelyev, 2004, Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice., Clin Cancer Res, 10, 8028, 10.1158/1078-0432.CCR-04-0621

Lieber, 1975, Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas., Int J Cancer, 15, 741, 10.1002/ijc.2910150505

Vezeridis, 1990, Heterogeneity of potential for hematogenous metastasis in a human pancreatic carcinoma., J Surg Res, 48, 51, 10.1016/0022-4804(90)90145-R

Bruns, 1999, In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice., Neoplasia, 1, 50, 10.1038/sj.neo.7900005

McCarty, 2002, Quantitative and qualitative in vivo angiogenesis assay., Int J Oncol, 21, 5

Mukhopadhyay, 1995, Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation., Nature, 375, 577, 10.1038/375577a0

Biscardi, 2000, Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer., Breast Cancer Res, 2, 203, 10.1186/bcr55

Gruden, 2003, IGF-I induces vascular endothelial growth factor in human mesangial cells via a Src-dependent mechanism., Kidney Int, 63, 1249, 10.1046/j.1523-1755.2003.00857.x

Ellis, 1998, Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for c-src., J Biol Chem, 273, 1052, 10.1074/jbc.273.2.1052

Anand, 2003, Regulation of vascular endothelial growth factor production by Leydig cells in vitro: the role of protein kinase A and mitogen-activated protein kinase cascade., Biol Reprod, 68, 1663, 10.1095/biolreprod.102.009795

Duyndam, 2003, Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite., J Biol Chem, 278, 6885, 10.1074/jbc.M206320200

Fleming, 1997, Regulation of vascular endothelial growth factor expression in human colon carcinoma cells by activity of src kinase., Surgery, 122, 501, 10.1016/S0039-6060(97)90044-1

Issbrucker, 2003, p38 MAP kinase-a molecular switch between VEGF-induced angiogenesis and vascular hyperpermeability., FASEB J, 17, 262, 10.1096/fj.02-0329fje

Jung, 1999, Extracellular signal-regulated kinase activation is required for up-regulation of vascular endothelial growth factor by serum starvation in human colon carcinoma cells., Cancer Res, 59, 4804

Milanini-Mongiat, 2002, Identification of two Sp1 phosphorylation sites for p42/p44 mitogen-activated protein kinases: their implication in vascular endothelial growth factor gene transcription., J Biol Chem, 277, 20631, 10.1074/jbc.M201753200

Suzuma, 2002, Stretch-induced retinal vascular endothelial growth factor expression is mediated by phosphatidylinositol 3-kinase and protein kinase C (PKC)-zeta but not by stretch-induced ERK1/2, Akt, Ras, or classical/novel PKC pathways., J Biol Chem, 277, 1047, 10.1074/jbc.M105336200

Xiong, 2004, Molecular targeting therapy for pancreatic cancer., Cancer Chemother Pharmacol, 54, S69

Windham, 2002, Src activation regulates anoikis in human colon tumor cell lines., Oncogene, 21, 7797, 10.1038/sj.onc.1205989

Tokuda, 2003, p38 MAP kinase regulates BMP-4-stimulated VEGF synthesis via p70 S6 kinase in osteoblasts., Am J Physiol Endocrinol Metab, 284, 1202, 10.1152/ajpendo.00300.2002

Tokuda, 2003, Involvement of MAP kinases in TGF-beta-stimulated vascular endothelial growth factor synthesis in osteoblasts., Arch Biochem Biophys, 415, 117, 10.1016/S0003-9861(03)00225-X

Douziech, 1999, Activation of MAP kinases in growth responsive pancreatic cancer cells., Cell Signal, 11, 591, 10.1016/S0898-6568(99)00030-3

Liu, 2002, Hepatocyte growth factor enhances endothelial cell barrier function and cortical cytoskeletal rearrangement: potential role of glycogen synthase kinase-3beta., FASEB J, 16, 950, 10.1096/fj.01-0870com

Matsuda, 2002, Multiple mitogenic pathways in pancreatic cancer cells are blocked by a truncated epidermal growth factor receptor., Cancer Res, 62, 5611

McMullen, 2003, Vascular endothelial growth factor-mediated activation of p38 is dependent upon Src and RAFTK/Pyk2., Oncogene, 23, 1275, 10.1038/sj.onc.1207243

Pal, 2001, Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma., Cancer Res, 61, 6952

Sawyer, 2001, Src inhibitors: genomics to therapeutics., Expert Opin Investig Drugs, 10, 1327, 10.1517/13543784.10.7.1327

Sawyer, 2004, Cancer metastasis therapeutic targets and drug discovery: emerging small-molecule protein kinase inhibitors., Expert Opin Investig Drugs, 13, 1, 10.1517/13543784.13.1.1

Tsygankov, 2004, Src: regulation, role in human carcinogenesis and pharmacological inhibitors., Curr Pharm Des, 10, 1745, 10.2174/1381612043384457

Shah, 2004, Overriding imatinib resistance with a novel ABL kinase inhibitor., Science, 305, 399, 10.1126/science.1099480

Duxbury, 2004, Inhibition of SRC tyrosine kinase impairs inherent and acquired gemcitabine resistance in human pancreatic adenocarcinoma cells., Clin Cancer Res, 10, 2307, 10.1158/1078-0432.CCR-1183-3

Weis, 2004, Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis., J Cell Biol, 167, 223, 10.1083/jcb.200408130