Zoledronate-activated Vγ9γδ T cell-based immunotherapy is feasible and restores the impairment of γδ T cells in patients with solid tumors

Cytotherapy - Tập 13 - Trang 92-97 - 2011
Atsutaka Noguchi1,2, Toru Kaneko1, Takashi Kamigaki1, Katsunada Fujimoto1, Masanori Ozawa1, Masashi Saito1, Naoko Ariyoshi2, Shigenori Goto1
1Seta Clinic Group, Tokyo, Japan
2Medinet Medical Institute, Medinet Co. Ltd, Tokyo, Japan

Tài liệu tham khảo

Rosenberg, 1985, Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer, N Engl J Med, 313, 1485, 10.1056/NEJM198512053132327 Goto, 2006, The therapeutic potential of immuno-cell therapy of cancer in combination with aminobisphosphonates, Anticancer Res, 26, 3989 Hirooka, 2009, A combination therapy of gemcitabine with immunotherapy for patients with inoperable locally advanced pancreatic cancer, Pancreas, 38, 69, 10.1097/MPA.0b013e318197a9e3 Takayama, 2000, Adoptive immunotherapy to lower postsurgical recurrence rates of hepatocellular carcinoma: a randomized trial, Lancet, 356, 802, 10.1016/S0140-6736(00)02654-4 Ferrarini, 2002, Human gammadelta T cells: a nonredundant system in the immune-surveillance against cancer, Trends Immunol, 23, 14, 10.1016/S1471-4906(01)02110-X Sicard, 2005, In vivo immunomanipulation of V gamma 9 V delta 2 T cells with a synthetic phosphoantigen in a preclinical nonhuman primate model, J Immunol, 175, 5471, 10.4049/jimmunol.175.8.5471 Kunzmann, 2000, Stimulation of gamma delta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma, Blood, 96, 384, 10.1182/blood.V96.2.384 Wilhelm, 2003, Gammadelta T cells for immune therapy of patients with lymphoid malignancies, Blood, 102, 200, 10.1182/blood-2002-12-3665 Abe, 2009, Clinical and immunological evaluation of zoledronate-activated Vgamma9gammadelta T-cell-based immunotherapy for patients with multiple myeloma, Exp Hematol, 37, 956, 10.1016/j.exphem.2009.04.008 Kobayashi, 2007, Safety profile and anti-tumor effects of adoptive immunotherapy using gamma-delta T cells against advanced renal cell carcinoma: a pilot study, Cancer Immunol Immunother, 56, 469, 10.1007/s00262-006-0199-6 Kondo, 2008, Zoledronate facilitates large-scale ex vivo expansion of functional gammadelta T cells from cancer patients for use in adoptive immunotherapy, Cytotherapy, 10, 842, 10.1080/14653240802419328 Goto, 1999, Analysis of Th1 and Th2 cytokine production by peripheral blood mononuclear cells as a parameter of immunologic dysfunction in advanced cancer patients, Cancer Immunol Immunother, 48, 435, 10.1007/s002620050620 Caccamo, 2005, Differential requirements for antigen or homeostatic cytokines for proliferation and differentiation of human Vgamma9Vdelta2 naive, memory and effector T cell subsets, Eur J Immunol, 35, 1764, 10.1002/eji.200525983