ZnS Nanoparticle Catalysed Four Component Syntheses of Novel Spiropolyhydroquinoline Derivatives in Aqueous Medium Under Ultrasonic Irradiation

Anshu Dandia1, Ruby Singh1, Shyam L. Gupta1, Kuldeep S. Rathore2
1Department of Chemistry, Centre of Advanced Studies, University of Rajasthan, Jaipur, India
2Semiconductor and Polymer Science Laboratory, Department of Physics, University of Rajasthan, Jaipur, India

Tóm tắt

An environmental friendly, one pot, four components ZnS nanoparticles (NPs) catalyzed synthesis of biologically important spiropolyhydroquinoline derivatives in water under ultrasonic irradiation is described. The four component reaction of substituted cyclic ketones, 5,5-dimethyl-1,3-cyclohexanedione, meldrum’s acid, and amines/ammonium acetate in which formation of multiple carbon–carbon bonds occurs in a single step does not involve any hazardous organic solvent or catalyst. The target compounds have been obtained in good yield. After the reaction, ZnS NP can be recycled and reused without any apparent loss of activity.

Tài liệu tham khảo

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