Zn salen complex supported on MnCoFe2O4(MCF) magnetic nanoparticles as a catalyst in the synthesis of 3,4-dihydropyrimidin-2 (1H)-ones/thiones (Biginelli-like reaction)

Research on Chemical Intermediates - 2022
Najmieh Ahadi1,2, Akbar Mobinikhaledi1,2, Armaghan Fathehesami2, Zahra Bagheri2
1Institute of Nanosciences and Nanotechnology, Arak University, Arak, Iran
2Department of Chemistry, Faculty of Science, Arak University, Arak, Iran

Tóm tắt

In the present work, a novel Zn salen complex supported on MnCoFe2O4 magnetic nanoparticles, MnCoFe2O4@SiO2-Pr-NH-SA&Zn (MCF@SiO2-Pr-NH-SA&Zn) was easily synthesized by a clean method and fully characterized by Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction, Field emission-scanning electron microscopy, Energy dispersive X-ray analyzer, Transmission electron microscopy, Inductively coupled plasma-optical emission spectrometry, Thermogravimetric and Vibrating sample magnetometery analyses. Moreover, the activity of the prepared complex as a heterogeneous catalyst was investigated in Biginelli-like reaction via three component reaction ethyl acetoacetate or dimedone/ or barbituric acid, urea/ or thiourea and different aromatic aldehydes. The structure of new prepared 3,4-dihydropyrimidin-2 (1H)-ones/thions was properly identified by FT-IR, 1H- and 13C-NMR spectroscopy data. Some important advantages of this procedure include easy separation of catalyst by a magnet, short reaction times, excellent yield of products, solvent free, easy work-up and reusability of the catalyst during 6 runs of the used model reaction.

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