Zerumbone inhibits migration in ESCC via promoting Rac1 ubiquitination

Siegel, 2015, Cancer statistics, 2015, CA Cancer J. Clin., 65, 5, 10.3322/caac.21254 Wang, 2012, Attributable causes of esophageal cancer incidence and mortality in China, PLoS One, 7, e42281, 10.1371/journal.pone.0042281 Arnold, 2015, Global incidence of oesophageal cancer by histological subtype in 2012, Gut, 64, 381, 10.1136/gutjnl-2014-308124 Lagergren, 2017, Oesophageal cancer, Lancet, 390, 2383, 10.1016/S0140-6736(17)31462-9 Catenacci, 2017, Rilotumumab plus epirubicin, cisplatin, and capecitabine as first-line therapy in advanced MET-positive gastric or gastro-oesophageal junction cancer (RILOMET-1): a randomised, double-blind, placebo-controlled, phase 3 trial, The Lancet, Oncology, 18, 1467 Foley, 2018, Development and validation of a prognostic model incorporating texture analysis derived from standardised segmentation of PET in patients with oesophageal cancer, Eur. Radiol., 28, 428, 10.1007/s00330-017-4973-y Rutegard, 2017, The prognostic role of coeliac node metastasis after resection for distal oesophageal cancer, Sci. Rep., 7, 43744, 10.1038/srep43744 Yob, 2011, Zingiber zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses, Evid. Complement. Alternat. Med., 2011 Singh, 2018, Zerumbone reduces proliferation of HCT116 colon cancer cells by inhibition of TNF-alpha, Sci. Rep., 8, 4090, 10.1038/s41598-018-22362-1 Kim, 2014, Zerumbone suppresses EGF-induced CD44 expression through the inhibition of STAT3 in breast cancer cells, Oncol. Rep., 32, 2666, 10.3892/or.2014.3514 Kim, 2016, Zerumbone suppresses the motility and tumorigenecity of triple negative breast cancer cells via the inhibition of TGF-beta1 signaling pathway, Oncotarget, 7, 1544, 10.18632/oncotarget.6441 Wang, 2016, Zerumbone induces gastric cancer cells apoptosis: Involving cyclophilin A, Biomed. Pharmacother., 83, 740, 10.1016/j.biopha.2016.07.034 Kalantari, 2017, A review of the biomedical applications of Zerumbone and the techniques for its extraction from Ginger Rhizomes, Molecules, 22, 10.3390/molecules22101645 Chiang, 2018, Zerumbone regulates dna repair responding to ionizing radiation and enhances radiosensitivity of human prostatic cancer cells, Integr. Cancer Ther., 17, 292, 10.1177/1534735417712008 Lv, 2018, Zerumbone suppresses the potential of growth and metastasis in hepatoma HepG2 cells via the MAPK signaling pathway, Oncol. Lett., 15, 7603 Weng, 2012, Zerumbone suppresses IKKalpha, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells, J. Biomed. Sci., 19, 86, 10.1186/1423-0127-19-86 Abdelwahab, 2012, Zerumbone inhibits interleukin-6 and induces apoptosis and cell cycle arrest in ovarian and cervical cancer cells, Int. Immunopharmacol., 12, 594, 10.1016/j.intimp.2012.01.014 Sun, 2013, Zerumbone induces apoptosis in human renal cell carcinoma via Gli-1/Bcl-2 pathway, Pharmazie, 68, 141 Marei, 2017, Rac1 in human diseases: the therapeutic potential of targeting Rac1 signaling regulatory mechanisms, Small GTPases, 8, 139, 10.1080/21541248.2016.1211398 Vincent, 2017, EMT, inflammation and metastasis, Semin. Cancer Biol., 47, 168, 10.1016/j.semcancer.2017.09.003 Tzeng, 2013, Zerumbone, a natural cyclic sesquiterpene of zingiber zerumbet smith, attenuates nonalcoholic fatty liver disease in hamsters fed on high-fat diet, Evid. Complement. Alternat. Med., 2013, 303061 Haque, 2018, Zerumbone suppresses the activation of inflammatory mediators in LPS-stimulated U937 macrophages through MyD88-dependent NF-kappaB/MAPK/PI3K-Akt signaling pathways, Int. Immunopharmacol., 55, 312, 10.1016/j.intimp.2018.01.001 Ho, 2017, Zerumbone reduced the inflammatory response of acute lung injury in endotoxin-treated mice via Akt-NFkappaB pathway, Chem. Biol. Interact., 271, 9, 10.1016/j.cbi.2017.04.017 Tsuboi, 2014, Zerumbone inhibits tumor angiogenesis via NF-kappaB in gastric cancer, Oncol. Rep., 31, 57, 10.3892/or.2013.2842 Saranya, 2017, Effects of a new synthetic zerumbone pendant derivative (ZPD) on apoptosis induction and anti-migratory effects in human cervical cancer cells, Chem. Biol. Interact., 278, 32, 10.1016/j.cbi.2017.10.006 Zainal, 2018, Zerumbone targets the CXCR4-RhoA and PI3K-mTOR signaling axis to reduce motility and proliferation of oral cancer cells, Phytomedicine, 39, 33, 10.1016/j.phymed.2017.12.011 Deorukhkar, 2015, Zerumbone increases oxidative stress in a thiol-dependent ROS-independent manner to increase DNA damage and sensitize colorectal cancer cells to radiation, Cancer Med., 4, 278, 10.1002/cam4.367 Jeon, 2016, Elevated IL-1beta expression induces invasiveness of triple negative breast cancer cells and is suppressed by zerumbone, Chem. Biol. Interact., 258, 126, 10.1016/j.cbi.2016.08.021 Kang, 2016, Zerumbone Suppresses Osteopontin-Induced Cell Invasion Through Inhibiting the FAK/AKT/ROCK Pathway in Human Non-Small Cell Lung Cancer A549 Cells, J. Nat. Prod., 79, 156, 10.1021/acs.jnatprod.5b00796 Ma, 2018, Effects of zerumbone on proliferation and apoptosis of esophageal cancer cells and on P53 and Bcl-2 expression levels, Oncol. Lett., 16, 4379 Jegannathan, 2016, Zerumbone, a Sesquiterpene, Controls Proliferation and Induces Cell Cycle Arrest in Human Laryngeal Carcinoma Cell Line Hep-2, Nutr. Cancer Int. J., 68, 865, 10.1080/01635581.2016.1159701 Tsuboi, 2014, Zerumbone inhibits tumor angiogenesis via NF-kappaB in gastric cancer, Oncol. Rep., 31, 57, 10.3892/or.2013.2842 Shamoto, 2014, Zerumbone inhibits angiogenesis by blocking NF-kappaB activity in pancreatic cancer, Pancreas, 43, 396, 10.1097/MPA.0000000000000039 Samad, 2018, Zerumbone suppresses angiogenesis in HepG2 cells through inhibition of matrix Metalloproteinase-9, vascular endothelial growth factor, and vascular endothelial growth factor receptor expressions, Pharaacogn. Mag., 13, S731 Zainal, 2018, Zerumbone targets the CXCR4-RhoA and PI3K-mTOR signaling axis to reduce motility and proliferation of oral cancer cells, Phytomedicine, 39, 33, 10.1016/j.phymed.2017.12.011 Jorvig, 2015, Zerumbone inhibits growth of hormone refractory prostate cancer cells by inhibiting JAK2/STAT3 pathway and increases paclitaxel sensitivity, Anticancer Drugs, 26, 160, 10.1097/CAD.0000000000000171 Yan, 2016, Epithelial-mesenchymal expression phenotype of primary melanoma and matched metastases and relationship with overall survival, Anticancer Res., 36, 6449, 10.21873/anticanres.11243 Park, 2016, Estradiol, TGF-beta1 and hypoxia promote breast cancer stemness and EMT-mediated breast cancer migration, Oncol. Lett., 11, 1895, 10.3892/ol.2016.4115 Daly, 2018, Hypoxia modulates the stem cell population and induces EMT in the MCF-10A breast epithelial cell line, Oncol. Rep., 39, 483 Zhao, 2013, NF-kappaB-mediated inflammation leading to EMT via miR-200c is involved in cell transformation induced by cigarette smoke extract, Toxicol. Sci., 135, 265, 10.1093/toxsci/kft150 Prasanphanich, 2014, Redox processes inform multivariate transdifferentiation trajectories associated with TGFbeta-induced epithelial-mesenchymal transition, Free Radic. Biol. Med., 76, 1, 10.1016/j.freeradbiomed.2014.07.032 Gao, 2017, Inhibition of glycogen synthase kinase 3 beta (GSK3β) suppresses the progression of Esophageal Squamous Cell Carcinoma by modifying STAT3 activity, Mol. Carcinog., 56, 2301, 10.1002/mc.22685 Zoni, 2015, Epithelial Plasticity in Cancer: Unmasking a MicroRNA Network for TGF-beta-, Notch-, and Wnt-Mediated EMT, J. Oncol., 2015, 10.1155/2015/198967 Yang, 2016, FCN2 inhibits epithelial-mesenchymal transition-induced metastasis of hepatocellular carcinoma via TGF-beta/Smad signaling, Cancer Lett., 378, 80, 10.1016/j.canlet.2016.05.007 Xu, 2015, 14-3-3zeta turns TGF-beta’s function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2, Cancer Cell, 27, 177, 10.1016/j.ccell.2014.11.025 Jiang, 2016, Prognostic value of high FoxC2 expression in resectable non-small cell lung cancer, alone or in combination with E-cadherin expression, BMC Cancer, 16, 16, 10.1186/s12885-016-2056-0 Kook, 2010, Prognostic value of E-cadherin expression in non-small cell lung cancer treated with gefitinib, Oncol. Res., 18, 445, 10.3727/096504010X12671222663674 Qiu, 2018, P2Y2 receptor promotes the migration and invasion of breast cancer cells via EMT-related genes Snail and E-cadherin, Oncol. Rep., 39, 138 Ma, 2017, MiR-23a promotes TGF-beta1-induced EMT and tumor metastasis in breast cancer cells by directly targeting CDH1 and activating Wnt/beta-catenin signaling, Oncotarget, 8, 69538, 10.18632/oncotarget.18422 Li, 2016, The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocarcinoma cells, Sci. Rep., 6, 26971, 10.1038/srep26971 Deng, 2018, Mangiferin inhibits cell migration and invasion through Rac1/WAVE2 signalling in breast cancer, Cytotechnology, 70, 593, 10.1007/s10616-017-0140-1 Su, 2014, A putative novel protein, DEPDC1B, is overexpressed in oral cancer patients, and enhanced anchorage-independent growth in oral cancer cells that is mediated by Rac1 and ERK, J. Biomed. Sci., 21, 67, 10.1186/s12929-014-0067-1 Zhou, 2016, Rac1 overexpression is correlated with epithelial mesenchymal transition and predicts poor prognosis in non-small cell lung cancer, J. Cancer, 7, 2100, 10.7150/jca.16198 Leng, 2015, Rac1 expression in epithelial ovarian cancer: effect on cell EMT and clinical outcome, Med. Oncol., 32, 329, 10.1007/s12032-014-0329-5 Chen, 2015, mTOR regulate EMT through RhoA and Rac1 pathway in prostate cancer, Mol. Carcinog., 54, 1086, 10.1002/mc.22177 Bid, 2013, RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis, Mol. Cancer Ther., 12, 1925, 10.1158/1535-7163.MCT-13-0164 Nie, 2015, Gene silencing of Rac1 with RNA interference mediated by ultrasound and microbubbles in human LoVo cells: evaluation of cell invasion inhibition and metastatic, J. Drug Target., 23, 380, 10.3109/1061186X.2014.1002500