Zerumbone from Zingiber zerumbet inhibits innate and adaptive immune responses in Balb/C mice

Mohamed, 2017, Naturally occurring immunomodulators with antitumor activity: an insight on their mechanisms of action, Int. Immunopharmacol., 50, 291, 10.1016/j.intimp.2017.07.010 Haque, 2017, Exploring the immunomodulatory and anticancer properties of zerumbone, Food Funct., 8, 3410, 10.1039/C7FO00595D Arshad, 2017, Immunosuppressive effects of natural α, β-unsaturated carbonyl-based compounds, and their analogs and derivatives, on immune cells: a review, Front. Pharmacol., 8, 22, 10.3389/fphar.2017.00022 Haque, 2018, Zerumbone suppresses the activation of inflammatory mediators in LPS-stimulated U937 macrophages through MyD88-dependent NF-κB/MAPK/PI3K-Akt signaling pathways, Int. Immunopharmacol., 55, 312, 10.1016/j.intimp.2018.01.001 Jonsson, 2013, Application of OECD Guideline 423 in assessing the acute oral toxicity of moniliformin, Food Chem. Toxicol., 53, 27, 10.1016/j.fct.2012.11.023 Huyan, 2011, Immunosuppressive effect of cyclophosphamide on white blood cells and lymphocyte subpopulations from peripheral blood of Balb/c mice, Int. Immunopharmacol., 11, 1293, 10.1016/j.intimp.2011.04.011 Ilangkovan, 2016, Phyllanthin from Phyllanthus amarus inhibits cellular and humoral immune responses in Balb/C mice, Phytomedicine, 23, 1441, 10.1016/j.phymed.2016.08.002 Ahmad, 2016, Standardized extract of Tinospora crispa stimulates innate and adaptive immune responses in Balb/c mice, Food Funct., 7, 1380, 10.1039/C5FO01531F Arshad, 2018, 3,5-Bis[4-(diethoxymethyl)benzylidene]-1-methyl-piperidin-4-one, a novel curcumin analogue, inhibits cellular and humoral immune responses in male Balb/c mice, Curr. Pharm. Biotechnol., 19, 468, 10.2174/1389201019666180703092723 Gupta, 2006, Immunomodulatory activity of biopolymeric fraction RLJ-NE-205 from Picrorhiza kurroa, Int. Immunopharmacol., 6, 1543, 10.1016/j.intimp.2006.05.002 Ray, 2010, Isolation of mouse peritoneal cavity cells, J. Vis. Exp., 35, 1488 Manson, 1994, Test methods for assessing female reproductive and developmental toxicology, Prince. Met. Toxicol., 27, 989 Coleman, 2001, Nitric oxide in immunity and inflammation, Int. Immunopharmacol., 1, 1397, 10.1016/S1567-5769(01)00086-8 Guzik, 2003, Nitric oxide and superoxide in inflammation, J. Physiol. Pharmacol., 54, 469 Chien, 2008, Anti-inflammatory constituents of Zingiber zerumbet, Food Chem., 110, 584, 10.1016/j.foodchem.2008.02.038 Jones, 2007, Modulation of LPS stimulated NF-kappaB mediated nitric oxide production by PKCε and JAK2 in RAW macrophages, J. Inflammat., 4, 23, 10.1186/1476-9255-4-23 Van der Veen, 2009, Myeloperoxidase: molecular mechanisms of action and their relevance to human health and disease, Antiox. Redox. Signal., 11, 2899, 10.1089/ars.2009.2538 Malynn, 1984, Role of antigen-specific B cells in the induction of SRBC-specific T cell proliferation, J. Immunol., 132, 2253, 10.4049/jimmunol.132.5.2253 Luckheeram, 2012, CD4+ T cells: differentiation and functions, Clin. Develop. Immunol., 2012, 10.1155/2012/925135 Harikrishnan, 2018, Anti-inflammatory effects of Hypophyllanthin and Niranthin through downregulation of NF-κB/MAPKs/PI3K-Akt signaling pathways, Inflammation, 41, 984, 10.1007/s10753-018-0752-4 Dinarello, 2000, Proinflammatory cytokines, Chest J., 118, 503, 10.1378/chest.118.2.503 Seruga, 2008, Cytokines and their relationship to the symptoms and outcome of cancer, Nat. Rev. Cancer, 8, 887, 10.1038/nrc2507 Singh, 1999, The paradigm of Th1 and Th2 cytokines, Immunol. Res., 20, 147, 10.1007/BF02786470 Jorvig, 2015, Zerumbone inhibits growth of hormone refractory prostate cancer cells by inhibiting JAK2/STAT3 pathway and increases paclitaxel sensitivity, Anti-Cancer Drug, 26, 160, 10.1097/CAD.0000000000000171 Ryan, 2005, Activated human B lymphocytes express cyclooxygenase-2 and cyclooxygenase inhibitors attenuate antibody production, J. Immunol., 174, 2619, 10.4049/jimmunol.174.5.2619 von Bubnoff, 2001, Antigen-presenting cells in allergy, J. Allerg. Clin. Immunol., 108, 329, 10.1067/mai.2001.117457 Benacerraf, 1978, Opinion: a hypothesis to relate the specificity of T lymphocytes and the activity of I region-specific Ir genes in macrophages and B lymphocytes, J. Immunol., 120, 1809, 10.4049/jimmunol.120.6.1809