Zellen und Matrix im Blasenknorpel einer durch D-Penicillamin veränderten Ratten-Tibiaepiphysenfuge

D-Penicillamine induces an osteolathyrism in rat epiphyseal plate. In hypertrophic cartilage single cell necrosis and morphologically unaltered chondrocytes are found. In cartilage matrix collagenous fibrils show periodic cross-bandings, which repeat at intervals of about 640 Å. The cartilagineous mineral compaired with the controls contains amorphous calcium phosphate in a higher amount.