Zebrafish as a potential non-traditional model organism in translational bipolar disorder research: Genetic and behavioral insights

Addington, 2005, GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume loss, Mol. Psychiatry, 10, 581, 10.1038/sj.mp.4001599 Aho, 2017, Homeostatic response to sleep/rest deprivation by constant water flow in larval zebrafish in both dark and light conditions, J. Sleep. Res., 26, 394, 10.1111/jsr.12508 Aizawa, 2013, Habenula and the asymmetric development of the vertebrate brain, Anat. Sci. Int., 88, 1, 10.1007/s12565-012-0158-6 Alavi, 2018, Orphan G protein-coupled receptors: the role in CNS disorders, Biomed. Pharm., 98, 222, 10.1016/j.biopha.2017.12.056 Alazizi, 2011, Identification, characterization, and ontogenic study of a catechol O-methyltransferase from zebrafish, Aquat. Toxicol., 102, 18, 10.1016/j.aquatox.2010.12.016 Almeida, 2020, Genetic differences between bipolar disorder subtypes: a systematic review focused in bipolar disorder type II, Neurosci. Biobehav. Rev., 118, 623, 10.1016/j.neubiorev.2020.07.033 Anderson, 2012, Bipolar disorder, BMJ, 345, 10.1136/bmj.e8508 Barman, 1991, A taxonomic revision of the Indo-Burmese species of Danio Hamilton-Buchanan, Rec. Zool. Sur India Occ., Paper 137, 1 Belelli, 2009, Extrasynaptic GABAA receptors: form, pharmacology, and function, J. Neurosci., 29, 12757, 10.1523/JNEUROSCI.3340-09.2009 Beyer, 2017, Animal models for bipolar disorder: from bedside to the cage, Int J. Bipolar Disord., 5, 35, 10.1186/s40345-017-0104-6 Bill, 2009, A primer for morpholino use in zebrafish, Zebrafish, 6, 69, 10.1089/zeb.2008.0555 Bilotta, 1999, Establishing and maintaining a low-cost zebrafish breeding and behavioral research facility, Behav. Res. Methods Instrum. Comput., 31, 178, 10.3758/BF03207707 Blank, 2009, A one-trial inhibitory avoidance task to zebrafish: rapid acquisition of an NMDA-dependent long-term memory, Neurobiol. Learn Mem., 92, 529, 10.1016/j.nlm.2009.07.001 Blazina, 2013, The spinning task: a new protocol to easily assess motor coordination and resistance in zebrafish, Zebrafish, 10, 480, 10.1089/zeb.2012.0860 Boehmler, 2004, Evolution and expression of D2 and D3 dopamine receptor genes in zebrafish, Dev. Dyn., 230, 481, 10.1002/dvdy.20075 Boehmler, 2013, Genomic strategies for the identification of dopamine receptor genes in zebrafish, Methods Mol. Biol., 964, 201, 10.1007/978-1-62703-251-3_12 Bosma, 1999, Multiplicity of glutamic acid decarboxylases (GAD) in vertebrates: molecular phylogeny and evidence for a new GAD paralog, Mol. Biol. Evol., 16, 397, 10.1093/oxfordjournals.molbev.a026120 Brambilla, 2003, MRI investigation oftemporal lobe structures in bipolar patients, J. Psychiatr., 37, 287 Bu, 1994, The exon-intron organization of the genes (GAD1 and GAD2) encoding two human glutamate decarboxylases (GAD67 and GAD65) suggests that they derive from a common ancestral GAD, Genomics, 21, 222, 10.1006/geno.1994.1246 Cachat, 2010, Measuring behavioral and endocrine responses to novelty stress in adult zebrafish, Nat. Protoc., 5, 1786, 10.1038/nprot.2010.140 Cachat, 2011, Three-dimensional neurophenotyping of adult zebrafish behavior, PLoS One, 6, 10.1371/journal.pone.0017597 Caligiuri, 2000, Motor and cognitive aspects of motor retardation in depression, J. Affect. Disord. J. Affect. Disord., 57, 83, 10.1016/S0165-0327(99)00068-3 Canzian, 2019, Single pentylenetetrazole exposure increases aggression in adult zebrafish at different time intervals, Neurosci. Lett., 692, 27, 10.1016/j.neulet.2018.10.045 Canzian, 2019, Modeling psychiatric comorbid symptoms of epileptic seizures in zebrafish, J. Psychiatr. Res., 119, 14, 10.1016/j.jpsychires.2019.09.007 Capogna, 2011, GABA A,slow: causes and consequences, Trends Neurosci., 34, 101, 10.1016/j.tins.2010.10.005 Chen, 2010, Translational research in bipolar disorder: emerging insights from genetically based models, Mol. Psychiatry, 15, 883, 10.1038/mp.2010.3 Chou, 2016, Association between the serotonin transporter and cytokines: Implications for the pathophysiology of bipolar disorder, J. Affect Disord., 191, 29, 10.1016/j.jad.2015.10.056 Cordero-maldonado, 2018, Deep learning image recognition enables efficient genome editing in Zebrafish by auto-mated injections, No. Mlcm, 1 da Rosa, 2017, Just Keep swimming: neuroendocrine, metabolic, and behavioral changes after a forced swimming test in Zebrafish, Zebrafish, 14, 51, 10.1089/zeb.2016.1340 Dahlbom, 2012, Aggression and monoamines: effects of sex and social rank in zebrafish (Danio rerio), Behav. Brain Res., 228, 333, 10.1016/j.bbr.2011.12.011 Darland, 2001, Behavioral screening for cocaine sensitivity in mutagenized zebrafish, Proc. Natl. Acad. Sci. USA, 98, 11691, 10.1073/pnas.191380698 De bruyn, 1996, A linkage study between bipolar disorder and genes involved in dopaminergic and GABAergic neurotransmission, Psychiatr. Genet, 6, 67, 10.1097/00041444-199622000-00006 Demin, 2020, The zebrafish tail immobilization (ZTI) test as a new tool to assess stress-related behavior and a potential screen for drugs affecting despair-like states, J. Neurosci. Methods, 337, 10.1016/j.jneumeth.2020.108637 Disease, 2018, Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017, Lancet, 392, 1789, 10.1016/S0140-6736(18)32279-7 Dodd, 2015, Future directions for pharmacotherapies for treatment-resistant bipolar disorder, Curr. Neuropharmacol., 13, 656, 10.2174/1570159X13666150630175841 Egan, 2001, Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia, Proc. Natl. Acad. Sci. USA, 98, 6917, 10.1073/pnas.111134598 Egan, 2009, Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish, Behav. Brain Res., 205, 38, 10.1016/j.bbr.2009.06.022 Einat, 2014, New ways of modeling bipolar disorder, Harv. Rev. Psychiatry, 22, 348, 10.1097/HRP.0000000000000059 Einat, 2003, New approaches to modeling bipolar disorder, Psychopharmacol. Bull., 37, 47 Ellis, 2012, A larval zebrafish model of bipolar disorder as a screening platform for neuro-therapeutics, Behav. Brain Res., 10.1016/j.bbr.2012.05.043 Ellis, 2012, A larval zebrafish model of bipolar disorder as a screening platform for neuro-therapeutics, Behav. Brain Res., 233, 450, 10.1016/j.bbr.2012.05.043 Ellis, 2012, Distinct models of induced hyperactivity in zebrafish larvae, Brain Res., 1449, 46, 10.1016/j.brainres.2012.02.022 Emilien, 1999, Dopamine receptors--physiological understanding to therapeutic intervention potential, Pharm. Ther., 84, 133, 10.1016/S0163-7258(99)00029-7 Emilien, 1999, Dopamine receptors and schizophrenia: contribution of molecular genetics and clinical neuropsychology, Int J. Neuropsychopharmacol., 2, 197, 10.1017/S1461145799001479 Erlander, 1991, Two genes encode distinct glutamate decarboxylases, Neuron, 7, 91, 10.1016/0896-6273(91)90077-D Fontana, 2016, Modulatory action of taurine on ethanol-induced aggressive behavior in zebrafish, Pharm. Biochem Behav., 141, 18, 10.1016/j.pbb.2015.11.011 Fontana, 2018, The developing utility of zebrafish models of neurological and neuropsychiatric disorders: a critical review, Exp. Neurol., 299, 157, 10.1016/j.expneurol.2017.10.004 Franscescon, 2020, Neuroprotective role of taurine on MK-801-induced memory impairment and hyperlocomotion in zebrafish, Neurochem Int., 135, 10.1016/j.neuint.2020.104710 Franscescon, 2021, Taurine prevents MK-801-induced shoal dispersion and altered cortisol responses in zebrafish, Prog. Neuropsychopharmacol. Biol. Psychiatry, 111, 10.1016/j.pnpbp.2021.110399 Gaspary, 2018, Novel object recognition and object location tasks in zebrafish: Influence of habituation and NMDA receptor antagonism, Neurobiol. Learn Mem., 155, 249, 10.1016/j.nlm.2018.08.005 Gerlai, 2020, Evolutionary conservation, translational relevance and cognitive function: the future of zebrafish in behavioral neuroscience, Neurosci. Biobehav Rev., 116, 426, 10.1016/j.neubiorev.2020.07.009 Gerlai, 2000, Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects, Pharm. Biochem Behav., 67, 773, 10.1016/S0091-3057(00)00422-6 Gould, 2007, Animal models of bipolar disorder and mood stabilizer efficacy: a critical need for improvement, Neurosci. Biobehav Rev., 31, 825, 10.1016/j.neubiorev.2007.05.007 Graeden, 2009, Live imaging of the zebrafish embryonicbrain by confocal microscopy, J. Vis. Exp., 26, 1217 Grande, 2016, Bipolar disorder, Lancet, 387, 1561, 10.1016/S0140-6736(15)00241-X Greengard, 2001, The neurobiology of dopamine signaling, Biosci. Rep., 21, 247, 10.1023/A:1013205230142 Grossman, 2010, Characterization of behavioral and endocrine effects of LSD on zebrafish, Behav. Brain Res., 214, 277, 10.1016/j.bbr.2010.05.039 Guidotti, 2000, Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study, Arch. Gen. Psychiatry, 57, 1061, 10.1001/archpsyc.57.11.1061 Guldberg, 1975, Catechol-O-methyl transferase: pharmacological aspects and physiological role, Pharm. Rev., 27, 135 Hande, 2021, Population genetic variation of SLC6A4 gene, associated with neurophysiological development, J. Genet, 100, 10.1007/s12041-021-01266-6 Haug, 2013, Phylogeny and expression divergence of metabotropic glutamate receptor genes in the brain of zebrafish (Danio rerio), J. Comp. Neurol., 521, 1533, 10.1002/cne.23240 Heckers, 2002, Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia, Arch. Gen. Psychiatry, 59, 521, 10.1001/archpsyc.59.6.521 Higashijima, 2004, Distribution of prospective glutamatergic, glycinergic, and GABAergic neurons in embryonic and larval zebrafish, J. Comp. Neurol., 480, 1, 10.1002/cne.20278 Hildebrand, 2017, Whole-brain serial-section electron microscopy in larval zebrafish, Nature, 545, 345, 10.1038/nature22356 Holzschuh, 2001, Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo, Mech. Dev., 101, 237, 10.1016/S0925-4773(01)00287-8 Howe, 2013, The zebrafish reference genome sequence and its relationship to the human genome, Nature, 496, 498, 10.1038/nature12111 Hruscha, 2013, Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish, Development, 140, 4982, 10.1242/dev.099085 Hu, 2007, XBP-1, a key regulator of unfolded protein response, activates transcription of IGF1 and Akt phosphorylation in zebrafish embryonic cell line, Biochem Biophys. Res Commun., 359, 778, 10.1016/j.bbrc.2007.05.183 Huang, 2012, Novel expression patterns of metabotropic glutamate receptor 6 in the zebrafish nervous system, PLoS One, 7 Hwang, 2013, Efficient genome editing in zebrafish using a CRISPR-Cas system, Nat. Biotechnol., 31, 227, 10.1038/nbt.2501 Ito, 2009, Non-laminar cerebral cortex in teleost fishes?, Biol. Lett., 5, 10.1098/rsbl.2008.0397 Jesuthasan, 2012, Fear, anxiety, and control in the zebrafish, Dev. Neurobiol., 72, 395, 10.1002/dneu.20873 Kalueff, 2013, Towards a comprehensive catalog of zebrafish behavior 1.0 and beyond, Zebrafish, 10, 70, 10.1089/zeb.2012.0861 Karolewicz, 2010, Reduced level of glutamic acid decarboxylase-67 kDa in the prefrontal cortex in major depression, Int J. Neuropsychopharmacol., 13, 411, 10.1017/S1461145709990587 Kato, 2007, Animal models of bipolar disorder, Neurosci. Biobehav Rev., 31, 832, 10.1016/j.neubiorev.2007.03.003 Keung, 1993, Daidzin: a potent, selective inhibitor of human mitochondrial aldehyde dehydrogenase, Proc. Natl. Acad. Sci., 90, 1247, 10.1073/pnas.90.4.1247 Keung, 1998, Daidzin and its antidipsotropic analogs inhibit serotonin and dopamine metabolism in isolated mitochondria, Proc. Natl. Acad. Sci. USA, 95, 2198, 10.1073/pnas.95.5.2198 Kimmel, 1995, Stages of embryonic development of the zebrafish, Dev. Dyn., 203, 253, 10.1002/aja.1002030302 Kokel, 2008, Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish, Brief. Funct. Genom. Prote, 7, 483, 10.1093/bfgp/eln040 Konarski, 2005, Is the cerebellum relevant in the circuitry of neuropsychiatric disorders?, J. Psychiatry Neurosci., 30, 178 Kopeykina, 2016, Hypersexuality and couple relationships in bipolar disorder: a review, J. Affect Disord., 195, 1, 10.1016/j.jad.2016.01.035 Laroche, 2013, The embryonic expression patterns of zebrafish genes encoding LysM-domains, Gene Expr. Patterns, 13, 212, 10.1016/j.gep.2013.02.007 Lassen, 2005, Molecular cloning, baculovirus expression, and tissue distribution of the zebrafish aldehyde dehydrogenase 2, Drug Metab. Dispos., 33, 649, 10.1124/dmd.104.002964 Lee, 2010, The ALDH2 and DRD2/ANKK1 genes interacted in bipolar II but not bipolar I disorder, Pharm. Genom., 20, 500, 10.1097/FPC.0b013e32833caa2b Lee, 2012, The ALDH2 and 5-HT2A genes interacted in bipolar-I but not bipolar-II disorder, Prog. Neuropsychopharmacol. Biol. Psychiatry, 38, 247, 10.1016/j.pnpbp.2012.04.005 Lohi, 2013, The zebrafish as a model for paediatric diseases, Acta Paediatr., 102, 104, 10.1111/j.1651-2227.2012.02835.x Lu, 2012, Profiling of gene duplication patterns of sequenced teleost genomes: evidence for rapid lineage-specific genome expansion mediated by recent tandem duplications, BMC Genom., 13, 246, 10.1186/1471-2164-13-246 Lv, 2019, Sleep deprivation caused a memory defects and emotional changes in a rotenone-based zebrafish model of Parkinson’s disease, Behav. Brain Res., 372, 10.1016/j.bbr.2019.112031 Machado-Vieira, 2004, Perspectives for the development of animal models of bipolar disorder, Prog. Neuropsychopharmacol. Biol. Psychiatry, 28, 209, 10.1016/j.pnpbp.2003.10.015 MacRae, 2003, Zebrafish-based small molecule discovery, Chem. Biol., 10, 901, 10.1016/j.chembiol.2003.10.003 Madeira, 2017, Long-term social recognition memory in Zebrafish, Zebrafish, 14, 305, 10.1089/zeb.2017.1430 Mannisto, 1999, Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors, Pharm. Rev., 51, 593 Markou, 2009, Removing obstacles in neuroscience drug discovery: the future path for animal models, Neuropsychopharmacology, 34, 74, 10.1038/npp.2008.173 Martin, 1993, Regulation of gamma-aminobutyric acid synthesis in the brain, J. Neurochem., 60, 395, 10.1111/j.1471-4159.1993.tb03165.x Martin, 1998, Sequence and expression of glutamic acid decarboxylase isoforms in the developing zebrafish, J. Comp. Neurol., 396, 253, 10.1002/(SICI)1096-9861(19980629)396:2<253::AID-CNE9>3.0.CO;2-# Mason, 2016, Historical underpinnings of bipolar disorder diagnostic criteria, Behav. Sci., 6, 10.3390/bs6030014 McElroy, 2016, Prevalence and correlates of DSM-5 eating disorders in patients with bipolar disorder, J. Affect. Disord. J. Affect. Disord., 191, 216, 10.1016/j.jad.2015.11.010 Miller, 2012, From schooling to shoaling: patterns of collective motion in zebrafish (Danio rerio), PLoS One, 7, 10.1371/journal.pone.0048865 Miller, 2011, Shoaling in zebrafish: what we don’t know, Rev. Neurosci., 22, 17, 10.1515/rns.2011.004 Mills, 2005, MRI analysis of cerebellar vermal abnormalities in bipolar disorder, Am. J. Psychiatry, 162, 1530, 10.1176/appi.ajp.162.8.1530 Missale, 1998, Dopamine receptors: from structure to function, Physiol. Rev., 78, 189, 10.1152/physrev.1998.78.1.189 Miyawaki, 2020, Application of zebrafish to safety evaluation in drug discovery, J. Toxicol. Pathol., 33, 197, 10.1293/tox.2020-0021 Mueller, 2008, Early teleostean basal gan-glia development visualized by zebrafish Dlx2a, Lhx6, Lhx7, Tbr2 (eomesa), and GAD67 gene expression, J. Comp. Neurol., 507, 1245, 10.1002/cne.21604 Mustafa, 2019, The aggressive spiegeldanio, carrying a mutation in the fgfr1a gene, has no advantage in dyadic fights with zebrafish of the AB strain, Behav. Brain Res., 370, 10.1016/j.bbr.2019.111942 Neuhauss, 2003, Retinal defects in the zebrafish bleached mutant, Doc. Ophthalmol., 107, 71, 10.1023/A:1024492029629 Ng, 2012, Effect of MK-801-induced impairment of inhibitory avoidance learning in zebrafish via inactivation of extracellular signal-regulated kinase (ERK) in telencephalon, Fish. Physiol. Biochem., 38, 1099, 10.1007/s10695-011-9595-8 Ngoc Hieu, 2020, Development of a modified three-day T-maze protocol for evaluating learning and memory capacity of adult Zebrafish, Int J. Mol. Sci., 21, 10.3390/ijms21041464 Ni, 2006, 5-hydroxytryptamine in the cardiovascular system: focus on the serotonin transporter (SERT), Clin. Exp. Pharm. Physiol., 33, 575, 10.1111/j.1440-1681.2006.04410.x Nofzinger, 1991, Hypersomnia in bipolar depression: a comparison with narcolepsy using the multiple sleep latency test, Am. J. Psychiatry, 148, 1177, 10.1176/ajp.148.9.1177 Oliveira, 2015, The zebrafish world of colors and shapes: preference and discrimination, Zebrafish, 12, 166, 10.1089/zeb.2014.1019 Oliveira, 2011, Fighting zebrafish: characterization of aggressive behavior and winner-loser effects, Zebrafish, 8, 73, 10.1089/zeb.2011.0690 Overli, 1999, Short-term effects of fights for social dominance and the establishment of dominant-subordinate relationships on brain monoamines and cortisol in rainbow trout, Brain Behav. Evol., 54, 263, 10.1159/000006627 Paige, 2014, Construction of an affordable and easy-to-build zebrafish facility, J. Vis. Exp., 10.3791/51989 Parker, 2012, Housing conditions differentially affect physiological and behavioural stress responses of Zebrafish, as well as the response to anxiolytics, PLoS One, 7, 10.1371/journal.pone.0034992 Pavlidis, 2011, Adaptive changes in zebrafish brain in dominant-subordinate behavioral context, Behav. Brain Res., 225, 529, 10.1016/j.bbr.2011.08.022 Perathoner, 2016, Potential of Zebrafish as a model for exploring the role of the amygdala in emotional memory and motivational behavior, J. Neurosci. Res., 94, 445, 10.1002/jnr.23712 Ponzoni, 2016, Ritanserin-sensitive receptors modulate the prosocial and the anxiolytic effect of MDMA derivatives, DOB and PMA, in zebrafish, Behav. Brain Res., 314, 181, 10.1016/j.bbr.2016.08.009 Postlethwait, 1998, Vertebrate genome evolution and the zebrafish gene map, Nat. Genet, 18, 345, 10.1038/ng0498-345 Prather, 2009, Cytokine-induced depression during IFN-alpha treatment: the role of IL-6 and sleep quality, Brain Behav. Immun., 23, 1109, 10.1016/j.bbi.2009.07.001 Randlett, 2015, Whole-brain activity mapping onto a ze-brafish brain atlas, Nat. Methods, 12, 1039, 10.1038/nmeth.3581 Rico, 2011, Zebrafish neurotransmitter systems as potential pharmacological and toxicologicaltargets, Neurotoxicology Teratol., 33, 608, 10.1016/j.ntt.2011.07.007 Rihel, 2012, Behavioral screening for neuroactive drugs in zebrafish, Dev. Neurobiol., 72, 373, 10.1002/dneu.20910 Rihel, 2010, Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation, Science, 327, 348, 10.1126/science.1183090 Rissone, 2018, Rare genetic blood disease modeling in Zebrafish, Front Genet., 9, 348, 10.3389/fgene.2018.00348 Rosemberg, 2011, Differences in spatio-temporal behavior of zebrafish in the open tank paradigm after a short-period confinement into dark and bright environments, PLoS One, 6, 10.1371/journal.pone.0019397 Rosemberg, 2012, Behavioral effects of taurine pretreatment in zebrafish acutely exposed to ethanol, Neuropharmacology, 63, 613, 10.1016/j.neuropharm.2012.05.009 Rosso, 2007, Reduced amygdala volumes infirst-episode bipolar disorderand correlation with cerebral white matter, Biol. Psychiatry, 61, 743, 10.1016/j.biopsych.2006.07.035 Santini, 2015, The association between social relationships and depression: a systematic review, J. Affect Disord., 175, 53, 10.1016/j.jad.2014.12.049 Saverino, 2008, The social Zebrafish: behavioral responses to conspecific, heterospecific, and computer animated fish, Behav. Brain Res, 191, 77, 10.1016/j.bbr.2008.03.013 Schmidt, 2013, Neurogenesis in Zebrafish - from embryo to adult, Neural Dev., 8, 3, 10.1186/1749-8104-8-3 Seibt, 2010, Antipsychotic drugs prevent the motor hyperactivity induced by psychotomimetic MK-801 in zebrafish (Danio rerio), Behav. Brain Res., 214, 417, 10.1016/j.bbr.2010.06.014 Semenova, 2017, Distribution, properties, and inhibitor sensitivity of zebrafish catechol-O-methyl transferases (COMT), Biochem. Pharm., 145, 147, 10.1016/j.bcp.2017.08.017 Seungju, 2021, Brain microdialysis coupled to LC-MS/MS revealed that CVT-10216, a selective inhibitor of aldehyde dehydrogenase 2, alters the neurochemical and behavioral effects of methamphetamine, ACS Chem. Neurosci., 12, 1552, 10.1021/acschemneuro.1c00039 Severus, 2013, Diagnosing bipolar disorders in DSM-5, Int. J. Bipolar Disord., 1, 14, 10.1186/2194-7511-1-14 Shen, 2021, A native, highly active Tc1/mariner transposon from zebrafish (ZB) offers an efficient genetic manipulation tool for vertebrates, Nucleic Acids Res., 49, 2126, 10.1093/nar/gkab045 Souery, 1996, Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes, Am. J. Med. Genet, 67, 551, 10.1002/(SICI)1096-8628(19961122)67:6<551::AID-AJMG7>3.0.CO;2-K Stefanello, 2019, Exploring object discrimination in Zebrafish: behavioral performance and scopolamine-induced cognitive deficits at different retention intervals, Zebrafish, 16, 370, 10.1089/zeb.2018.1703 Stewart, 2014, Zebrafish models for translational neuroscience research: from tank to bedside, Trends Neurosci., 37, 264, 10.1016/j.tins.2014.02.011 Stewart, 2015, Molecular psychiatry of zebrafish, Mol. Psychiatry, 20, 2, 10.1038/mp.2014.128 Stober, 1998, Insertion/deletion variant (-141C Ins/Del) in the 5′ regulatory region of the dopamine D2 receptor gene: lack of association with schizophrenia and bipolar affective disorder. Short communication, J. Neural Transm. (Vienna), 105, 101, 10.1007/s007020050041 Tran, 2015, An integrative analysis of ethanol tolerance and withdrawal in zebrafish (Danio rerio), Behav. Brain Res, 276, 161, 10.1016/j.bbr.2014.02.034 Vieta, 2007, Evolving trends in the long-term treatment of bipolar disorder, World J. Biol. Psychiatry, 8, 4, 10.1080/15622970601083280 Wang, 2006, Characterization and expression of serotonin transporter genes in zebrafish, Tohoku J. Exp. Med., 208, 267, 10.1620/tjem.208.267 Young, 2007, A reverse-translational approach to bipolar disorder: rodent and human studies in the Behavioral Pattern Monitor, Neurosci. Biobehav Rev., 31, 882, 10.1016/j.neubiorev.2007.05.009 Zhao, 2015, Association study of dopamine receptor genes polymorphism with cognitive functions in bipolar I disorder patients, J. Affect Disord., 170, 85, 10.1016/j.jad.2014.08.039