Yunnan Baiyao Inhibits Periodontitis by Suppressing the Autophagic Flux

Delatola, 2020, Three periodontitis phenotypes: bone loss patterns, antibiotic—surgical treatment and the new classification, J Clin Periodontol, 47, 1371, 10.1111/jcpe.13356 Lee, 2015, Periodontitis mainly increases osteoclast formation via enhancing the differentiation of quiescent osteoclast precursors into osteoclasts, J Periodontal Res, 50, 256, 10.1111/jre.12203 Park-Min, 2019, Metabolic reprogramming in osteoclasts, Semin Immunopathol, 41, 565, 10.1007/s00281-019-00757-0 Rossi, 2019, Del Fattore A The endocrine function of osteocalcin regulated by bone resorption: a lesson from reduced and increased bone mass diseases, Int J Mol Sci, 20, 4502, 10.3390/ijms20184502 Zhang, 2022, RNA sequencing reveals the regulation mechanism of Yunnan Baiyao in treating skin infection caused by Staphylococcus aureus, Evid Based Complement Alternat Med, 2022, 10.1155/2022/6348157 Yao, 2021, Research advances in pharmacology, safety, and clinical applications of Yunnan Baiyao, a traditional Chinese medicine formula, Front Pharmacol, 12, 10.3389/fphar.2021.773185 Ren, 2022, Yunnan Baiyao ameliorates rheumatoid arthritis in rats by shifting the Th17/Treg cell balance and preventing osteoclast differentiation, Evid Based Complement Alternat Med, 2022, 10.1155/2022/3764444 Galluzzi, 2019, Autophagy-independent functions of the autophagy machinery, Cell, 177, 1682, 10.1016/j.cell.2019.05.026 Mizushima, 2020, Autophagy in human diseases, N Engl J Med, 383, 1564, 10.1056/NEJMra2022774 Pierrefite-Carle, 2015, Autophagy in bone: self-eating to stay in balance, Ageing Res Rev, 24, 206, 10.1016/j.arr.2015.08.004 Dai, 2018, A RANKL-based osteoclast culture assay of mouse bone marrow to investigate the role of mTORC1 in osteoclast formation, J Vis Exp, 56468 Ho, 2020, In vivo and ex vivo actions of a novel P. gingivalis inhibitor on multi-species biofilm, inflammatory response, and periodontal bone loss, Mol Oral Microbiol, 35, 193, 10.1111/omi.12305 Hienz, 2015, Mechanisms of bone resorption in periodontitis, J Immunol Res, 2015, 10.1155/2015/615486 Kitaura, 2020, Osteocyte-related cytokines regulate osteoclast formation and bone resorption, Int J Mol Sci, 21, 5169, 10.3390/ijms21145169 Kim, 2020, Osteoblast-osteoclast communication and bone homeostasis, Cells, 9, 2073, 10.3390/cells9092073 Takito, 2018, The sealing zone in osteoclasts: a self-organized structure on the bone, Int J Mol Sci, 19, 984, 10.3390/ijms19040984 Liu, 2020, Mycobacterium tuberculosis infection increases the number of osteoclasts and inhibits osteoclast apoptosis by regulating TNF-alpha-mediated osteoclast autophagy, Exp Ther Med, 20, 1889 Xu, 2018, Simvastatin improves oral implant osseointegration via enhanced autophagy and osteogenesis of BMSCs and inhibited osteoclast activity, J Tissue Eng Regen Med, 12, 1209, 10.1002/term.2652 He, 2020, Chloroquine and 3-methyladenine attenuates periodontal inflammation and bone loss in experimental periodontitis, Inflammation, 43, 220, 10.1007/s10753-019-01111-0 Gelman, 2011, Autophagic factors cut to the bone, Dev Cell, 21, 808, 10.1016/j.devcel.2011.10.021 An, 2016, Increased autophagy is required to protect periodontal ligament stem cells from apoptosis in inflammatory microenvironment, J Clin Periodontol, 43, 618, 10.1111/jcpe.12549 Ebersole, 2021, Oral microbiome interactions with gingival gene expression patterns for apoptosis, autophagy and hypoxia pathways in progressing periodontitis, Immunology, 162, 405, 10.1111/imm.13292