You are never alone: crosstalk among epigenetic players

Science Bulletin - Tập 60 - Trang 899-904 - 2015
Cheng-Zhi Wang1, Bing Zhu1
1National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

Tóm tắt

Different cell types in a certain organism contain the same genome while running diverse transcription programs. This is controlled by epigenetic information, including DNA modifications, histone modifications, histone variants, non-coding RNAs, and chromatin architectures. Interestingly, recent progresses revealed extensive crosstalks among these epigenetic players. We discuss here how epigenetic players coordinate with each other to maintain epigenetic identities in mammal cells. More exciting researches are expected to expand our understanding regarding the epigenetic regulatory network.

Tài liệu tham khảo

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