Xylomexicanins A and B, New Δ14,15-Mexicanolides from Seeds of the Chinese Mangrove Xylocarpus granatum

Zeitschrift fur Naturforschung - Section C Journal of Biosciences - Tập 64 Số 1-2 - Trang 37-42 - 2009
Li‐Ru Shen1, Mei Dong2, Bao‐Wei Yin1, Dong Guo3, Manli Zhang1, Qing‐Wen Shi1, Changhong Huo1, Hiromasa Kiyota4, Nobuo N. Noda5, Bin Cong2
1Department of Medicinal Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, 050017, Hebei Province, P. R. China
2College of Basic Medicine, Hebei Medical University, 050017, Shijiazhuang, P. R. China
3North China Pharmaceutical Group Corporation, New Drug R&D Co., Ltd., 198 Huanghe Road, High Technology Industrial Zone, 050035, Shijiazhuang, Hebei Province, P. R. China
4Department of Bioscience and Biotechnology for Future Bioindustry, Graduate School of Agricultural Science, Tohoku University, 1 – 1 Tsutsumidori-Amamiya, Aoba-ku, Sendai, 981 – 8555, Japan
5Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University, Inohana 1 – 8 – 1, Chuoku, Chiba, 260 – 8670, Japan

Tóm tắt

Two new mexicanolide-type limonoids, named xylomexicanin A (1) and xylomexicanin B (2), were isolated from seeds of the Chinese mangrove Xylocarpus granatum. Their structures were elucidated on the basis of spectroscopic methods. Compound 1 exhibited antiproliferative activity against human breast carcinoma cells (KT), while 2 did not show inhibitory effects on eleven human tumour cell lines tested.

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Zeitschrift fur Naturforschung - Section C Journal of Biosciences

Tập 64 Số 1-2

37-42

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