Xpose—an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM

Sheiner, 1972, Modeling of individual pharmacokinetics for computer-aided drug dosage, Comput. Biomed. Res., 5, 441, 10.1016/0010-4809(72)90051-1 Sheiner, 1980, Evaluation of methods for estimating population pharmacokinetic parameters. I. Michaelis-Menten model: Routine clinical pharmacokinetic data, J. Pharmacokinet. Biopharm., 8, 553, 10.1007/BF01060053 S.L. Beal, L.B Sheiner (Eds.), NONMEM users guides, NONMEM project group University of California, San Francisco, CA, 1992. Aarons, 1994, Population approaches in drug development. Report on an expert meeting to discuss population pharmacokinetic/pharmacodynamic software, Eur. J. Clin. Pharmacol., 46, 389 M.O. Karlsson, E.N. Jonsson, C. Wiltse, J.R. Wade, Assumption testing in population pharmacokinetic models: Illustrated with an analysis of moxonidine data from congestive heart failure patients, submitted 1998. Mandema, 1992, Building population pharmacokinetic–pharmacodynamic models. I. Models for covariate effects, J. Pharmacokinet. Biopharm., 20, 511, 10.1007/BF01061469 E.N. Jonsson, M.O. Karlsson, Xpose—an S-PLUS based model building aid for population analysis with NONMEM, in: L. Aarons, L.P. Balant, M. Danhof et al. (Eds.), The Population Approach: Measuring and Managing Variability in Response, Concentration and Dose, European Commission, Brussels, 1997. Ette, 1997, Stability and performance of a population pharmacokinetic model, J. Clin. Pharmacol., 37, 486, 10.1002/j.1552-4604.1997.tb04326.x D. Verotta. Building population pharmacokinetic–pharmacodynamic models using trees, in: L. Aarons, L.P. Balant, M. Danhof, M. GexFabry, U.A. Gindert-Remy, M.O. Karlsson, F. Mentre, F. Rombout, M. Rowland, J.-L. Steimer, S. Vozeh (Eds.), The Population Approach: Measuring and Managing Variability in Response, Concentration and Dose, European Commission, Brussels, 1997. Ette, 1996, Comparing non-hierarchical models: Application to non-linear mixed effects modeling, Comput. Biol. Med., 26, 505, 10.1016/S0010-4825(96)00031-5 MathSoft. S-PLUS User's Manual, Version 3.4, Data analysis products division, MathSoft, Seattle, 1997. W.S. Cleveland, Visualizing data, Hobart press, Summit, New Jersey, 1993. A.C. Davison, E.J. Snell, Residuals and diagnostics, in: D.V. Hinkley, N. Reid, E.J. Snell (Eds.), Statistical Theory and Modelling: In honor of Sir David Cox, Chapman and Hall, London, 1991. E.N. Jonsson, M.O. Karlsson, Identification of factors that influence the importance of covariate relationships in population pharmacokinetic/pharmacodynamic models, submitted 1997.